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    HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS
    101.
    发明申请
    HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS 审中-公开
    对多巴胺神经元进行高通量筛选

    公开(公告)号：US20150377864A1

    公开(公告)日：2015-12-31

    申请号：US14766784

    申请日：2014-02-12

    Applicant: CELL CURE NEUROSCIENCES LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

    Inventor： Talya MORDECHAI DANIEL ,  Ofer WISER ,  Benjamin Eithan REUBINOFF

    IPC: G01N33/50

    CPC classification number: G01N33/5058 ,  G01N33/502 ,  G01N2333/70571

    Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.

    Abstract translation: 公开了一种确定药剂是否是神经递质的方法。 该方法包括：（a）将含有荧光多巴胺类似物的混合细胞群中的多巴胺能神经元标记; （b）测量混合细胞群体中的荧光水平; （c）将混合的细胞群暴露于所述试剂; （d）重新测量混合细胞群体中的荧光水平，其中荧光水平的变化指示物质是神经递质。

    Devices And Methods For Detection Of Internal Bleeding And Hematoma
    102.
    发明申请
    Devices And Methods For Detection Of Internal Bleeding And Hematoma 审中-公开
    用于检测内部出血和血肿的装置和方法

    公开(公告)号：US20150099980A1

    公开(公告)日：2015-04-09

    申请号：US14569396

    申请日：2014-12-12

    Applicant: Hadasit Medical Research Services and Development Ltd.

    Inventor： Dean Nahman ,  Yaron Ilan ,  Ilan Ben Oren ,  Yaron Bar-Ilan ,  Shmuel Chen

    IPC: A61B5/02 ,  A61B5/00

    CPC classification number: A61B5/02042 ,  A61B5/0075 ,  A61B5/4875 ,  A61B5/6833 ,  A61B2505/05

    Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

    Abstract translation: 提供了用于检测患者体内的内部出血的装置。 提供了用于将IR光透过患者皮肤区域并从皮肤区域收集IR光的光学接口。 在一些实施例中，光学接口包括一个或多个传送部件和一个或多个收集部件。 传送部件包括多个第一光通道，其被配置为将IR光穿过皮肤区域上的多个相应的第一子区域传输到身体的内部层。 收集组件包括多个第二光学通道，其被配置为从皮肤区域上的多个相应的第二子区域收集IR光。

    Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity
    103.
    发明申请
    Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity 有权
    用于改善和预防药物诱导毒性的组合物和方法

    公开(公告)号：US20150080348A1

    公开(公告)日：2015-03-19

    申请号：US14551724

    申请日：2014-11-24

    Applicant: Josef Mograbi ,  Hadasit Medical Research Services and Development Ltd.

    Inventor： Josef Mograbi ,  Yaron Ilan

    IPC: A61K31/661 ,  A61K45/06 ,  A61K31/10 ,  A61K31/198 ,  A61K31/357 ,  A61K31/197

    CPC classification number: A61K31/661 ,  A61K31/10 ,  A61K31/167 ,  A61K31/197 ,  A61K31/198 ,  A61K31/357 ,  A61K31/685 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

    Abstract: Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication.

    Abstract translation: 药物组合物，包括选自异水滑石B，甲磺酰甲烷（MSM），磷脂酰胆碱，半胱氨酸（Cys），硒半胱氨酸（Se-Cys），核糖半胱氨酸（RibCys），N-乙酰半胱氨酸（NAC），N-乙酰半胱氨酸 酰胺（AD4），甲硫氨酸（Met）和S-腺苷甲硫氨酸（SAM），用于降低和/或预防药物诱导的毒性，如对乙酰氨基酚诱导的毒性。 组合物可以配制有或没有对乙酰氨基酚，因此可以用作对乙酰氨基酚的安全配方，降低引起肝损伤的风险，或作为治疗对乙酰氨基酚过量的解毒剂。 对乙酰氨基酚中毒治疗方法。

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