公开(公告)号：US08070664B2

公开(公告)日：2011-12-06

申请号：US11814587

申请日：2006-01-23

申请人： Jean-Denis Rochat

发明人： Jean-Denis Rochat

IPC分类号： B04B7/06

CPC分类号： B04B5/0442 ,  B04B5/10 ,  B04B7/00 ,  B04B9/12 ,  B04B11/082 ,  B04B2005/0478 ,  B04B2007/005

摘要： The invention relates to disposable device for the continuous centrifugal separation of a physiological fluid. The inventive device comprises: a fixed axial element; a centrifugation chamber which is mounted such that it can rotate around the axis of said element; an inlet channel for the blood to be centrifuged, the dispensing port of which is located close to the base of the chamber; and an outlet passage for a separated constituent, the inlet port of which is located close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order for same to be removed continuously. The above-mentioned chamber takes the form of a long tube. The fixed axial element comprises a second outlet passage for a second of the separated constituents, the inlet port of which is located close to the end of the chamber opposite the above-mentioned base in a concentrated area of said second separated constituent having the highest mass density in order for same to be removed continuously.

摘要翻译： 本发明涉及用于生理流体的连续离心分离的一次性装置。 本发明的装置包括：固定的轴向元件; 离心室，其安装成使得其能够围绕所述元件的轴线旋转; 用于血液离心的入口通道，其分配端口位于靠近腔室的基部的位置; 以及用于分离的组分的出口通道，其入口在具有最低质量密度的一个分离组分的集中区域中靠近该腔室的另一端定位，以便连续地除去。 上述室采用长管的形式。 固定的轴向元件包括用于第二分离的组分的第二出口通道，其入口在所述第二分离组分的集中区域中靠近与上述碱基相对的端部，其具有最高质量 密度以便连续地被去除。

公开(公告)号：US20110022802A1

公开(公告)日：2011-01-27

申请号：US12458913

申请日：2009-07-27

申请人： Frederic Jean Denis Arsanto ,  Pierre Michel Boyer

发明人： Frederic Jean Denis Arsanto ,  Pierre Michel Boyer

IPC分类号： G06F12/00 ,  G06F12/08

CPC分类号： G06F12/0859 ,  G06F12/0862

摘要： Data storage circuitry for controlling access to data stored in a memory is disclosed. The data storage circuitry comprises: a data store for storing a subset of the data stored in the memory; access circuitry for receiving access requests and for outputting the requested data, at least some of the received access requests being ordered access requests requiring the accessed data to be output in a same order as the access requests are received in; control circuitry for controlling access to the data; and retrieval circuitry for retrieving the data from the memory; wherein the control circuitry is responsive to an access request received from the access circuitry to access the data store and in response to detecting a miss in the data store when the requested data is not stored in the data store to transmit the access request to the retrieval circuitry; the retrieval circuitry being configured to retrieve requested data from the memory in response to the access request and to store the data in the data store and being responsive to no asserted output inhibit signal associated with the data access request to transmit the retrieved data to the access circuitry for output and being responsive to an asserted output inhibit signal associated with the data access request not to transmit the retrieved data to the access circuitry; the data storage circuitry further comprising detection circuitry for detecting an earlier ordered access request that misses in the data store and a later ordered access request that hits while the earlier ordered access request is pending, the data storage circuitry being configured to halt the later ordered access request and in response to receipt of a subsequent ordered access request while the earlier ordered request is still pending to assert an output inhibit signal associated with the subsequent ordered access request and in response to detection of completion of the earlier ordered access request to deassert the output inhibit signal.

公开(公告)号：US07858755B2

公开(公告)日：2010-12-28

申请号：US10893485

申请日：2004-07-16

申请人： Valerie Wittamer ,  Jean-François Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel LePoul ,  Cecile Loison ,  Frédéric Ooms

发明人： Valerie Wittamer ,  Jean-François Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel LePoul ,  Cecile Loison ,  Frédéric Ooms

IPC分类号： C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/575 ,  C07K16/18 ,  C07K16/28 ,  G01N33/74 ,  G01N2500/02

摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

公开(公告)号：US20100215236A1

公开(公告)日：2010-08-26

申请号：US12675616

申请日：2008-08-01

申请人： Erwan Jolivet ,  Jean-Denis Laredo ,  Wafa Skalli ,  David Mitton

发明人： Erwan Jolivet ,  Jean-Denis Laredo ,  Wafa Skalli ,  David Mitton

IPC分类号： G06K9/62

CPC分类号： G06T17/00 ,  G01R33/5608 ,  G06T2210/41

摘要： A method of three-dimensionally reconstituting the shape of a singular body in a reference coordinate system and on the basis of initial imaging data acquired by an imaging system of the scanner or MRI type, wherein the method includes the steps of, constituting an approximate three-dimensional model of the singular body on the basis of a parameterizable generic model that is modified as a function of descriptive parameters derived from said initial data, and correcting the approximate model by comparing it (2) with the initial imaging data (D).

摘要翻译： 一种在参考坐标系中基于由扫描仪或MRI类型的成像系统获取的初始成像数据的三维重构单体的形状的方法，其中所述方法包括以下步骤：构成近似三 在基于从所述初始数据导出的描述性参数修改的可参数化通用模型的基础上对单体进行维度模型，并通过将其与初始成像数据（D）进行比较来校正近似模型。

公开(公告)号：US20100048373A1

公开(公告)日：2010-02-25

申请号：US12444788

申请日：2007-10-04

申请人： Jean-Denis Rochat

发明人： Jean-Denis Rochat

IPC分类号： B04B7/12 ,  B04B7/02

CPC分类号： B04B5/0442 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/12 ,  B04B11/02 ,  B04B11/082

摘要： The invention relates to a centrifugation enclosure (1) made of rigid plastic that comprises a member (1b) adapted to engage with the driving organ of a centrifugation machine (M) and a communication member (5) between the enclosure (1) and the outside, made of rigid plastic and comprising an first duct (5a) extending therethrough for supplying said enclosure (1) as well as two ducts (5b, 5c) extending therethrough for discharging the separated components. A holder (3) made of rigid plastic and having a network of channels (4a, 4b, 4c) formed therein connects the ducts (5a, 5b, 5c), respectively, to supply (P1) and reception (P2, P3) tanks, with side sealing members (6) of said channel network (4a, 4b, 4c). The ends of the ducts (5a, 5b, 5c) are adjacent to the respective ends of the channels (4a, 4b, 4c), and the ends of the ducts (5a, 5b, 5c) have surfaces mating with the end surfaces of the respective channels (4a, 4b, 4c), said mating surfaces being connected to one another.

摘要翻译： 本发明涉及由刚性塑料制成的离心机壳（1），其包括适于与离心机（M）的驱动机构接合的构件（1b）和位于外壳（1）和 外部由刚性塑料制成并且包括延伸穿过其中以供给所述外壳（1）的第一管道（5a）以及延伸穿过其中的用于排出分离的部件的两个管道（5b，5c）。 由刚性塑料制成并具有形成在其中的通道网络（4a，4b，4c）的支架（3）将导管（5a，5b，5c）分别连接到供给（P1）和接收（P2，P3） 与所述通道网络（4a，4b，4c）的侧密封构件（6）连接。 管道（5a，5b，5c）的端部与通道（4a，4b，4c）的相应端部相邻，并且管道（5a，5b，5c）的端部具有与端面 相应的通道（4a，4b，4c），所述配合表面彼此连接。

公开(公告)号：US07647357B2

公开(公告)日：2010-01-12

申请号：US10987570

申请日：2004-11-12

申请人： Robert Francis Bartfai ,  Pierre-Fortin Jean-Denis ,  Gail Andrea Spear ,  Sonny Earl Williams ,  Sherry Suzanne Worcester

发明人： Robert Francis Bartfai ,  Pierre-Fortin Jean-Denis ,  Gail Andrea Spear ,  Sonny Earl Williams ,  Sherry Suzanne Worcester

IPC分类号： G06F17/30 ,  G06F15/16

CPC分类号： G06F11/2064 ,  G06F11/2082

摘要： Provided are a method, system, deployment and program for managing data transfer in consistency group formation. In one embodiment, a transfer time for a data structure is selected as a function of at least one determined backlog. Upon expiration of the selected transfer time, the mode of operation may be switched. By dynamically selecting a transfer time, backlogs may be reduced to increase the likelihood of successful creation of a consistency group. Other embodiments are described and claimed.

摘要翻译： 提供了一种用于在一致性组形成中管理数据传输的方法，系统，部署和程序。 在一个实施例中，数据结构的传送时间被选择为至少一个确定的积压的函数。 在所选择的传送时间到期后，可以切换操作模式。 通过动态选择传输时间，可以减少积压以增加成功创建一致性组的可能性。 描述和要求保护其他实施例。

公开(公告)号：US20090204963A1

公开(公告)日：2009-08-13

申请号：US12068536

申请日：2008-02-07

申请人： Riaan Swart ,  Rodolph Gerard Jean-Denis Perfetta ,  David John Butcher

发明人： Riaan Swart ,  Rodolph Gerard Jean-Denis Perfetta ,  David John Butcher

IPC分类号： G06F9/455

CPC分类号： G06F9/44594 ,  G06F9/5022

摘要： A method of performing a processing task in a data processing apparatus is provided that reduces memory usage of the processing task. According to this method a Virtual Machine performs the steps of accessing platform-neutral program code in a function repository, executing the processing task on the Virtual Machine and analysing at a current execution point on a function-by-function basis which functions in the function repository are inactive functions. The Virtual Machine performs software-based unloading from the function repository of at least a portion of platform-neutral program code corresponding to one or more inactive functions. A corresponding virtual machine and data processing apparatus are also provided.

摘要翻译： 提供一种在数据处理装置中执行处理任务的方法，其减少处理任务的存储器使用。 根据这种方法，虚拟机执行在功能库中访问平台中立的程序代码的步骤，在虚拟机上执行处理任务，并且在功能基础上在功能基础上分析当前执行点，功能中的功能 存储库是非活动的功能。 虚拟机从功能库执行基于软件的至少一部分对应于一个或多个非活动功能的平台中立程序代码的卸载。 还提供了相应的虚拟机和数据处理装置。

公开(公告)号：US20090065424A1

公开(公告)日：2009-03-12

申请号：US12280093

申请日：2007-02-19

申请人： Jean-Denis Rochat

发明人： Jean-Denis Rochat

IPC分类号： B01D21/26 ,  B01D33/06

CPC分类号： B04B5/0442 ,  B04B1/00 ,  B04B11/06 ,  B04B2005/0464 ,  B04B2005/0478

摘要： One of the ends of this chamber has sealing means and is traversed by an intake channel for the blood that is to be centrifuged, and by at least one discharge channel). At least one circular deflector, concentric to the axis of revolution, is situated between the outlet of the intake channel and the admission port of the discharge channel in order to form an axial flow of the blood with a current counter to that formed against the lateral wall. This deflector has an alternating sequence of contiguous concave parts and convex parts that have or define between them crest lines or thalweg lines, at least some of these lines being inclined in the direction of the axis of revolution of the chamber.

摘要翻译： 该腔室的一个端部具有密封装置，并被用于要离心的血液的进气通道和至少一个排出通道穿过）。 至少一个与旋转轴线同心的圆形偏转器位于进气通道的出口和排放通道的进气口之间，以便形成血液的轴向流动，其电流与针对横向 壁。 该偏转器具有连续的凹部和凸起部分的交替序列，它们在它们之间具有或限定了顶部线或纬线，这些线中的至少一些在腔室的旋转轴线的方向上倾斜。

公开(公告)号：US20090043989A1

公开(公告)日：2009-02-12

申请号：US11889058

申请日：2007-08-08

申请人： Rodolph Gerard Jacques Ascanio Jean-Denis Perfetta

发明人： Rodolph Gerard Jacques Ascanio Jean-Denis Perfetta

IPC分类号： G06F9/30

CPC分类号： G06F9/30021 ,  G06F9/30058 ,  G06F9/30134

摘要： A processor 2 is provided with the ability to execute program instructions in the form of Java bytecodes including a dedicated null checking instruction. The null checking instruction reads the top of stack value, compares this with a null value and jumps to an exception handling routine if the top of stack value equals the null value, otherwise the next program instruction is executed.

摘要翻译： 处理器2具有执行包括专用空检查指令的Java字节码形式的程序指令的能力。 空检查指令读取堆栈值的顶部，将其与空值进行比较，如果堆栈值的顶部值等于空值，则跳转到异常处理例程，否则执行下一个程序指令。

公开(公告)号：US20080128367A1

公开(公告)日：2008-06-05

申请号：US11815419

申请日：2006-02-01

申请人： Jean-Denis Rochat

发明人： Jean-Denis Rochat

IPC分类号： B04B5/04 ,  B04B7/00 ,  B04B5/10 ,  A61M1/36 ,  B01D17/038

CPC分类号： B04B11/082

摘要： The inventive method for centrifugal separation of a determined volume of physiological liquid, in particular blood, at initial process step, consists in forming a flow of said liquid whose thickness is close to the size of largest particles (L3) contained therein at a volume ratio of

摘要翻译： 在初始工艺步骤中用于离心分离确定体积的生理液体，特别是血液的本发明的方法包括形成其体积比接近其中包含的最大颗粒（L3）尺寸的所述液体的流动， <1％时，为了增加其液面流量而减速所述液体流动，并将最大颗粒（L3）转移到离离心轴最近且密度最大的液相（L1）的表面， 在所述表面的外侧布置容量基本上等于所述最大颗粒（L3）的体积并且去除其密度最低的相（L2）的死体积。