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公开(公告)号：US10203327B2
公开(公告)日：2019-02-12
申请号：US15034721
申请日：2014-10-23
申请人： Frederic Bassilana , Birgit Uta Baumgarten , Nathalie Marie-Therese Carte , Michel Detheux , Rocco Falchetto , Sebastien Hannedouche , Vincent Lannoy , Keith Mansfield , Klaus Peter Seuwen , Thomas Laurent Henri Suply
发明人： Frederic Bassilana , Birgit Uta Baumgarten , Nathalie Marie-Therese Carte , Michel Detheux , Rocco Falchetto , Sebastien Hannedouche , Vincent Lannoy , Keith Mansfield , Klaus Peter Seuwen , Thomas Laurent Henri Suply
IPC分类号： C07K16/28 , G01N33/566
摘要： The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator may be a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
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公开(公告)号：US07858755B2
公开(公告)日：2010-12-28
申请号：US10893485
申请日：2004-07-16
申请人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
发明人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。
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3.发明申请Natural ligand for orphan G protein coupled receptor GPR86 and methods of use 失效孤儿G蛋白偶联受体GPR86的天然配体及其使用方法公开(公告)号：US20060078918A1
公开(公告)日：2006-04-13
申请号：US11216987
申请日：2005-08-31
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a method of detecting the dysregulation of GPR86 activity.
摘要翻译： 本发明涉及检测GPR86活性失调的方法。
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公开(公告)号：US20060024750A1
公开(公告)日：2006-02-02
申请号：US11134811
申请日：2005-05-20
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。
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公开(公告)号：US08030453B2
公开(公告)日：2011-10-04
申请号：US12389349
申请日：2009-02-19
申请人： Valerie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
发明人： Valerie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。
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公开(公告)号：US20100009345A1
公开(公告)日：2010-01-14
申请号：US11977949
申请日：2007-10-26
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , Daivd Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , Daivd Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。
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公开(公告)号：US20090047741A1
公开(公告)日：2009-02-19
申请号：US11978842
申请日：2007-10-30
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms , Silvano Sozzani
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms , Silvano Sozzani
CPC分类号： C07K14/475 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K16/24 , C07K16/2866 , C07K2317/34 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。
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公开(公告)号：US20050155090A1
公开(公告)日：2005-07-14
申请号：US10893485
申请日：2004-07-16
申请人： Valerie Wittamer , J. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms , Silvano Sozzani
发明人： Valerie Wittamer , J. Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms , Silvano Sozzani
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。
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公开(公告)号：US07842453B2
公开(公告)日：2010-11-30
申请号：US11977949
申请日：2007-10-26
申请人： Valeria Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Lepoul
发明人： Valeria Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Lepoul
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。
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10.发明授权公开(公告)号：US07582734B2
公开(公告)日：2009-09-01
申请号：US11529867
申请日：2006-09-29
申请人： Valeria Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Lepoul , Cecile Loison , Frederic Ooms
发明人： Valeria Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Lepoul , Cecile Loison , Frederic Ooms
CPC分类号： C07K14/475 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K16/24 , C07K16/2866 , C07K2317/34 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译： 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。
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