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    GAS SEPARATION PROCESSES
    101.
    发明申请
    GAS SEPARATION PROCESSES 有权
    气体分离过程

    公开(公告)号：US20150190784A1

    公开(公告)日：2015-07-09

    申请号：US14416405

    申请日：2013-07-26

    Applicant: Commonwealth Scientific and Industrial Research Organisation ,  Monash University

    Inventor： Bradley Ladewig ,  Richelle Lyndon ,  Matthew Hill

    IPC: B01J20/34 ,  B01J20/22 ,  B01D53/04

    CPC classification number: B01J20/3441 ,  B01D53/02 ,  B01D53/04 ,  B01D2253/204 ,  B01D2257/504 ,  B01D2259/40083 ,  B01J20/226 ,  B01J20/28011 ,  B01J20/3425 ,  B01J20/3433 ,  Y02C10/08

    Abstract: A process for the separation of a gas from a gas stream using metal organic framework that is reversibly switchable between a first conformation that allows the first gas species to be captured in the metal organic framework, and a second conformation that allows the release of the captured first gas species, using light as the switching stimulus. The metal organic framework may comprise a metal and one or more ligands, in which the ligands contain an isomerisable group within the molecular chain that forms a link between adjacent metal atoms in the metal organic framework.

    Abstract translation: 一种使用金属有机骨架从气流中分离出气体的方法，所述框架可在允许第一气体种类被捕获在金属有机骨架中的第一构象之间可逆地切换;以及第二构型，其允许所捕获的 第一种气体，使用光作为切换刺激。 金属有机骨架可以包含金属和一种或多种配体，其中配体在分子链内含有可异构化基团，其在金属有机骨架中形成相邻金属原子之间的连接。

    OPTIMISING CURRENT DIRECTION AND INTENSITY OF TRANSCRANIAL MAGNETIC STIMULATION
    102.
    发明申请
    OPTIMISING CURRENT DIRECTION AND INTENSITY OF TRANSCRANIAL MAGNETIC STIMULATION 审中-公开
    优化传统磁性刺激的电流方向和强度

    公开(公告)号：US20150174423A1

    公开(公告)日：2015-06-25

    申请号：US14402925

    申请日：2013-05-22

    Applicant: Monash University

    Inventor： Paul B. Fitzgerald ,  Richard H. Thomson

    IPC: A61N2/02 ,  A61B5/055 ,  A61B5/145 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/00 ,  A61N2/00 ,  A61B5/026

    CPC classification number: A61N2/02 ,  A61B5/0075 ,  A61B5/026 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/055 ,  A61B5/14542 ,  A61N2/006

    Abstract: A method of optimising transcranial magnetic stimulation is described. An electrical signal is applied to a coil to generate one or more magnetic field pulses for transcranial magnetic stimulation of a target cortical region of a patient. The transcranial magnetic stimulation has stimulation parameters including orientation of the coil relative to the patient and intensity of the magnetic stimulation. At least the orientation of the coil relative to the patient is varied. At different orientations of the coil relative to the patient, neuron activation at the target cortical region is determined by monitoring changes in blood flow and/or blood oxygenation, e.g. using near infra-red spectroscopy. Based on information obtained during the monitoring, one or more optimal coil orientations for the transcranial magnetic stimulation are determined. Apparatus for carrying out the method is also described.

    Abstract translation: 描述了一种优化经颅磁刺激的方法。 电信号被施加到线圈以产生用于患者的目标皮质区域的经颅磁刺激的一个或多个磁场脉冲。 经颅磁刺激具有刺激参数，包括线圈相对于患者的取向和磁刺激的强度。 至少线圈相对于患者的取向是不同的。 在线圈相对于患者的不同取向下，通过监测血流和/或血氧的变化来确定目标皮层区域的神经元活化，例如， 使用近红外光谱。 基于在监测期间获得的信息，确定经颅磁刺激的一个或多个最优线圈取向。 还描述了用于执行该方法的装置。

    AMINO ACID ANALOGUES AND METHODS FOR THEIR SYNTHESIS
    103.
    发明申请
    AMINO ACID ANALOGUES AND METHODS FOR THEIR SYNTHESIS 审中-公开
    氨基酸类似物及其合成方法

    公开(公告)号：US20150148524A1

    公开(公告)日：2015-05-28

    申请号：US14409509

    申请日：2013-07-08

    Applicant: MONASH UNIVERSITY

    Inventor： Zhen Wang ,  Andrea Robinson ,  Nicolas Daniel Spiccia ,  William Roy Jackson

    IPC: C07K1/00 ,  C07D255/02 ,  C07K2/00 ,  C07C269/06

    CPC classification number: C07K1/006 ,  C07C269/06 ,  C07C2603/18 ,  C07D255/02 ,  C07J9/00 ,  C07J41/0055 ,  C07K2/00 ,  C07C271/22

    Abstract: A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R1 and R2 are independently selected from H and substituted or unsubstituted C1 to C4 alkyl; each R3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted C1 to C20 alkyl, and a substituted or unsubstituted C1 to C20 alkyl group interrupted by one or more heteroatoms; and each X is independently selected from H and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).

    Abstract translation: 一种用于合成氨基酸类似物或其盐，溶剂合物，衍生物，异构体或互变异构体的方法，包括以下步骤：（i）使含有可复分解基团的氨基酸与含有互补可分解基团的化合物 （I）或（II）：（式（I），（II））其中R 1和R 2独立地选自H和取代或未取代的C 1至C 4烷基; 每个R 3不存在或独立地选自杂原子，取代或未取代的C 1至C 20烷基，以及被一个或多个杂原子间隔的取代或未取代的C 1至C 20烷基; 并且每个X独立地选自H和效应分子; 在试剂的存在下催化复分解，以在含有易位基团的氨基酸与含有互补易位基团的化合物之间形成二桥桥; 和（ii）还原二桥桥以形成饱和二碳桥，其中用于催化步骤（i）的试剂也催化步骤（ii）。

    Disease prevention by reactivation of the thymus
    104.
    发明申请
    Disease prevention by reactivation of the thymus 审中-公开
    疾病预防通过重新激活胸腺

    公开(公告)号：US20040259803A1

    公开(公告)日：2004-12-23

    申请号：US10749122

    申请日：2003-12-30

    Applicant: Monash University

    Inventor： Richard L. Boyd

    IPC: A61K038/09

    CPC classification number: A61K38/09 ,  A61K35/28 ,  A61K35/36 ,  A61K38/08 ,  Y02A50/48

    Abstract: The present disclosure provides methods for prevention and/or treatment of disease or illness in a patient by stimulating a patient's immune system through reactivation of the thymus. The patient's thymus is reactivated by interruption or ablation of sex steroid mediated signaling to the thymus, such as through the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMS), selective androgen receptor modulators (SARMS), aromatase inhibitors, or various combinations thereof. Non-limiting examples of illnesses or diseases that may be prevented or treated using the methods of the invention are those caused by viruses, bacteria, fungi, parasites, prions, cancers, allergens, asthma-inducing agents, or nullselfnull proteins and other antigens which cause autoimmune disease. In addition, optional gene therapy utilizing hematopoietic stem cells, lymphoid progenitor cells, and/or myeloid progenitor cells may be used in which the cells are administered to a patient in conjunction with treatment to reactivate the patient's thymus.

    Abstract translation: 本公开提供通过重新激活胸腺刺激患者的免疫系统来预防和/或治疗患者的疾病或疾病的方法。 例如通过施用LHRH激动剂，LHRH拮抗剂，抗LHRH受体抗体，抗LHRH疫苗，抗雄激素，抗雌激素，选择性的抗雌激素，通过中断或消除性类固醇介导的信号传导来重新激活患者的胸腺 雌激素受体调节剂（SERMS），选择性雄激素受体调节剂（SARMS），芳香酶抑制剂或其各种组合。 可以使用本发明的方法预防或治疗的疾病或疾病的非限制性实例是由病毒，细菌，真菌，寄生虫，朊病毒，癌症，变应原，哮喘诱导剂或“自身”蛋白质等引起的疾病或疾病的非限制性实例 导致自身免疫性疾病的抗原。 此外，可以使用使用造血干细胞，淋巴样祖细胞和/或骨髓祖细胞的任选的基因治疗，其中细胞与治疗一起施用以重新激活患者的胸腺。

    Long-term cell-culture compositions and genetically modified animals derived therefrom
    107.
    发明申请
    Long-term cell-culture compositions and genetically modified animals derived therefrom 审中-公开
    长期细胞培养组合物和衍生自其的转基因动物

    公开(公告)号：US20030143737A1

    公开(公告)日：2003-07-31

    申请号：US09732520

    申请日：2000-12-07

    Applicant: MONASH UNIVERSITY

    Inventor： John Roderick Morrison ,  Eric Shannon Hayes ,  Martin Frederick Pera ,  Orly Lacham-Kaplan ,  Alan Osborne Trounson

    IPC: C12N005/08

    CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K35/12 ,  C12N5/0623 ,  C12N15/8775 ,  C12N2500/25 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2510/04

    Abstract: The present invention generally relates to neural stem cells, preferably foetal neural stem cells and their progeny thereof. The present invention provides methods of isolating, culturing and propagating neural stem cells preferably foetal neural stem cells and the development of neural stem cell lines and lineages. The present invention also relates to the use of neural stem cells and somatic cells (eg rat fetal fibroblasts) and cells expressing the telomerase catalytic component (TERT) for gene targeting and gene knockout experiments and for producing genetically modified animals. In a first aspect of the present invention there is provided a cellular composition comprising one or more cells having a property characteristic of a neural stem cell and wherein said neural stem cell is capable of long term culture. Preferably the cells have a property characteristic of a foetal neural stem cell. In another aspect of the present invention there is provided a method of producing an animal, said method comprising introducing a continuously growing donor cell nucleus from a continuously growing donor cell into an oocyte or embryo and allowing the resulting embryo to mature and to preferably develop to a foetus or an adult animal.

    Abstract translation: 本发明一般涉及神经干细胞，优选胎儿神经干细胞及其后代。 本发明提供了分离，培养和繁殖神经干细胞，优选胎儿神经干细胞和神经干细胞系和谱系发育的方法。 本发明还涉及神经干细胞和体细胞（例如大鼠胎儿成纤维细胞）和表达端粒酶催化组分（TERT）的细胞用于基因靶向和基因敲除实验以及用于生产转基因动物的用途。 在本发明的第一方面，提供了包含一种或多种具有神经干细胞特性特征的细胞的细胞组合物，其中所述神经干细胞能够进行长期培养。 优选地，细胞具有胎儿神经干细胞的特性。 在本发明的另一方面，提供了一种生产动物的方法，所述方法包括将连续生长的供体细胞核从连续生长的供体细胞引入卵母细胞或胚胎中，并使所得胚胎成熟并优选发育成 胎儿或成年动物。

    SULFUR CATHODES
    108.
    发明申请
    SULFUR CATHODES 有权

    公开(公告)号：US20250158056A1

    公开(公告)日：2025-05-15

    申请号：US18877488

    申请日：2023-06-23

    Applicant: Monash University

    Inventor： Yingyi Huang ,  Mahdokht Shaibani ,  Matthew Hill ,  Mainak Majumder

    IPC: H01M4/58 ,  H01M4/02 ,  H01M10/0525

    Abstract: Sulfur cathodes which include cellulosic compositions containing a plurality of anionically functionalised cellulose nanofibres are described. The anionically functionalised cellulose nanofibres are highly charged and have a low aspect ratio. The sulfur cathodes possess low porosity, high surface smoothness and facilitate the transport of Li ions while hindering the transport of polysulfide anions. Batteries employing the sulfur cathodes have high gravimetric and volumetric density.

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