公开(公告)号：US20050236518A1

公开(公告)日：2005-10-27

申请号：US10830160

申请日：2004-04-21

申请人： Mark Scott

发明人： Mark Scott

IPC分类号： B64C27/08 ,  B64C27/10 ,  B64C27/32 ,  B64C27/46 ,  B64C27/605 ,  B64C27/615

CPC分类号： B64C27/605 ,  B64C27/10 ,  B64C27/322 ,  B64C27/46 ,  B64C27/615 ,  Y02T50/34

摘要： A dual, counter rotating, coaxial rotor system provides an upper and lower rotor system, with a reduced axial rotor separation distance along a common axis by means of rotor tip position sensing and rotor position controls to avoid tip contact.

摘要翻译： 双转子，反向旋转同轴转子系统提供上下转子系统，通过转子尖端位置检测和转子位置控制，沿着公共轴线减小轴向转子间隔距离，以避免尖端接触。

公开(公告)号：US20050152339A1

公开(公告)日：2005-07-14

申请号：US10978824

申请日：2004-11-02

申请人： Mark Scott ,  Anita Cheng

发明人： Mark Scott ,  Anita Cheng

IPC分类号： H04L12/24 ,  H04L12/66 ,  H04L12/56

CPC分类号： H04L41/142 ,  H04L41/22 ,  H04L41/5009 ,  H04L43/0829 ,  H04L43/0852 ,  H04L43/087 ,  H04L43/50 ,  H04L45/70

摘要： A method, system and computer program product for route checking and management is described herein. In a voice over internet protocol environment, the invention allows for the testing of routes among various gateways. In an embodiment, a method for selecting a route for a voice over IP call within a communications network is provided. The method includes receiving a VoIP call request from a user, identifying potential candidate routes, assessing the quality and cost of routes and determining a route based on cost, quality and/or user preferences.

摘要翻译： 本文描述了用于路由检查和管理的方法，系统和计算机程序产品。 在互联网语音协议环境中，本发明允许测试各种网关之间的路由。 在一个实施例中，提供了一种用于在通信网络内为IP呼叫选择路由的方法。 该方法包括从用户接收VoIP呼叫请求，识别潜在的候选路线，评估路线的质量和成本以及基于成本，质量和/或用户偏好确定路线。

公开(公告)号：US06251650B1

公开(公告)日：2001-06-26

申请号：US09687594

申请日：2000-10-13

申请人： Robert Donald Fallon ,  Mark James Nelson ,  Mark Scott Payne

发明人： Robert Donald Fallon ,  Mark James Nelson ,  Mark Scott Payne

IPC分类号： C12N978

CPC分类号： C12P13/02 ,  C12N9/78 ,  C12N9/80 ,  C12P7/40 ,  C12P17/00 ,  C12P41/006 ,  Y10S435/877

摘要： The present invention provides a nitrile hydratase nucleic acid fragment isolated from Pseudomonas putida which encodes a nitrile hydratase activity capable of catalyzing the hydrolysis of certain racemic nitriles to the corresponding R- or S-amides. Also provided are transformed microorganisms capable of the active expression of said nitrile hydratase activity. Additionally, the invention provides a transformant harboring the nitrile hydratase gene in conjunction with an amidase gene, both of which may be co-expressed producing active nitrile hydratase and amidase enzymes respectively. Methods for the production of such enantiomeric materials are also provided.

摘要翻译： 本发明提供从恶臭假单胞菌（Pseudomonas putida）分离的腈水合酶核酸片段，其编码能够将某些外消旋腈水解成相应的R-或S-酰胺的腈水合酶活性。 还提供了能够主动表达所述腈水合酶活性的转化微生物。 另外，本发明提供了一种携带腈水合酶基因的转化体，其与酰胺酶基因结合，两者都可以分别共同表达产生活性腈水合酶和酰胺酶。 还提供了生产这种对映体材料的方法。

公开(公告)号：US09115368B2

公开(公告)日：2015-08-25

申请号：US11982700

申请日：2007-11-01

申请人： Mark Scott Abad ,  Jaclyn Cleveland ,  Bettina Darveaux ,  Angie Ferguson ,  Barry S. Goldman ,  Balasulojini Karunanandaa ,  Maria McDonald ,  Daniel Riggsbee ,  Mahmood Sayed ,  Erin Slaten

发明人： Mark Scott Abad ,  Jaclyn Cleveland ,  Bettina Darveaux ,  Angie Ferguson ,  Barry S. Goldman ,  Balasulojini Karunanandaa ,  Maria McDonald ,  Daniel Riggsbee ,  Mahmood Sayed ,  Erin Slaten

IPC分类号： A01H5/00 ,  C12N15/82 ,  C12N15/63 ,  C07K14/415 ,  C12N9/02

CPC分类号： C12N15/8273 ,  C07K14/415 ,  C12N9/0008 ,  C12N15/8261 ,  C12N15/8271 ,  C12Y102/01016 ,  C12Y102/01024 ,  Y02A40/146

摘要： Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The invention also provides recombinant DNA molecules for expression of a protein.

摘要翻译： 具有改良性状的作物的转基因种子由改良重组DNA提供，其中与对照植物相比，从这种转基因种子生长的植物表现出一种或多种改良的性状。 特别感兴趣的是具有增加的产量的转基因植物。 本发明还提供用于表达蛋白质的重组DNA分子。

公开(公告)号：US08445242B2

公开(公告)日：2013-05-21

申请号：US13070130

申请日：2011-03-23

申请人： Robert DiCosimo ,  John Edward Gavagan ,  Mark Scott Payne

发明人： Robert DiCosimo ,  John Edward Gavagan ,  Mark Scott Payne

IPC分类号： C12P7/24 ,  C12N9/00 ,  C12N9/16 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C11D3/38636 ,  C11D3/3945 ,  C12N9/18 ,  C12P7/40 ,  C12Y301/01072 ,  D21C9/166

摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US08394616B2

公开(公告)日：2013-03-12

申请号：US13328350

申请日：2011-12-16

申请人： Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

发明人： Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

IPC分类号： C12N9/18 ,  C12P7/40 ,  A61L9/00

CPC分类号： C11D3/38636 ,  C11D3/2093 ,  C11D3/3942 ,  C11D3/3947 ,  C12N9/18 ,  C12P7/40 ,  C12Y301/01072 ,  D21C9/166

摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US08389259B2

公开(公告)日：2013-03-05

申请号：US13328381

申请日：2011-12-16

申请人： Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

发明人： Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

IPC分类号： C12N9/18 ,  C12P7/40 ,  A61L9/00

CPC分类号： A61L2/186 ,  A61L2/22 ,  A61L2/23 ,  A61L2202/24 ,  C12N9/18 ,  C12Y301/01072

摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US08389257B2

公开(公告)日：2013-03-05

申请号：US13328327

申请日：2011-12-16

申请人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

发明人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

IPC分类号： C12N9/18 ,  C12P7/40 ,  A61L9/00

CPC分类号： C12N9/18 ,  C11D3/38636 ,  C11D3/3945 ,  C12P7/40 ,  C12Y301/01072 ,  D21C9/166

摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US08389256B2

公开(公告)日：2013-03-05

申请号：US13328305

申请日：2011-12-16

申请人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

发明人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

IPC分类号： C12N9/18 ,  C12P7/40 ,  A61L9/00

CPC分类号： C11D3/3945 ,  C12N9/18 ,  C12P7/40 ,  C12P7/54 ,  C12Y301/01072 ,  D21C5/005 ,  D21C9/166

摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US20120183471A1

公开(公告)日：2012-07-19

申请号：US13201061

申请日：2010-02-17

申请人： Lloyd J. Old ,  Constance Old ,  Andrew Mark Scott ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Stephen Stockert ,  Vincent Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice ,  Anne Murray ,  George Mark ,  Terrance Grant Johns ,  Con Panousis ,  Christoph Renner

发明人： Lloyd J. Old ,  Constance Old ,  Andrew Mark Scott ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Stephen Stockert ,  Vincent Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice ,  Anne Murray ,  George Mark ,  Terrance Grant Johns ,  Con Panousis ,  Christoph Renner

IPC分类号： A61K39/395 ,  A61P35/00 ,  C12N1/19 ,  G01N33/574 ,  C12N5/10 ,  C12N1/21 ,  C07K16/30 ,  A61K51/00

CPC分类号： C07K16/40 ,  A61K31/495 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6871 ,  A61K51/103 ,  A61K51/1045 ,  A61K51/1078 ,  A61K2039/505 ,  A61K2300/00 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/4258 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

摘要翻译： 本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。 特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。 这些特异性结合成员可用于癌症的诊断和治疗。 本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。