公开(公告)号：US20150077535A1

公开(公告)日：2015-03-19

申请号：US14250846

申请日：2014-04-11

申请人： Duke University

发明人： Joseph A. Izatt ,  Shwetadwip Chowdhury

IPC分类号： G02B21/36 ,  G02B5/18 ,  H04N5/225 ,  G02B21/06

CPC分类号： G02B21/361 ,  G02B5/18 ,  G02B21/06 ,  G02B21/086 ,  G02B21/14 ,  G02B2005/1804 ,  H04N5/2256

摘要： Systems and methods for structured illumination super-resolution phase microscopy are disclosed. According to an aspect, an imaging system includes a light source configured to generate light. The system also includes a diffraction grating positioned to receive and diffract the output light. The system also includes a sample holder positioned to receive the diffracted light for transmission through a sample. Further, the system includes an image detector positioned to receive the light transmitted through the sample and configured to generate image data based on the received light. The system also includes a computing device configured to apply subdiffraction resolution reconstruction to the image data for generating an image of the sample.

摘要翻译： 公开了用于结构照明超分辨相位显微镜的系统和方法。 根据一个方面，成像系统包括被配置为产生光的光源。 该系统还包括被定位成接收和衍射输出光的衍射光栅。 该系统还包括定位成接收衍射光以便透过样品的样品架。 此外，该系统包括图像检测器，定位成接收透过样品的光，并被配置为基于接收的光产生图像数据。 该系统还包括被配置为对图像数据应用子分解分辨率重建以生成样本的图像的计算设备。

公开(公告)号：US20140354951A1

公开(公告)日：2014-12-04

申请号：US14372599

申请日：2013-01-24

申请人： Duke University

发明人： Joseph A. Izatt ,  Anthony N. Kuo ,  Ryan P. McNabb

IPC分类号： A61B3/10

CPC分类号： A61B3/102 ,  A61B3/117 ,  A61B3/1225 ,  A61B3/125 ,  A61B3/14 ,  A61F9/0008 ,  A61F9/00814 ,  A61F9/00827 ,  A61F2009/00851 ,  A61F2009/00863 ,  A61F2009/00868 ,  A61F2009/00891 ,  A61F2009/00897 ,  G01B9/02004 ,  G01B9/02058 ,  G01B9/02091 ,  G01B2290/65

摘要： A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam of light a focusing lens to focus the beam of light; and a contact lens to direct the beam of light into the eye of the subject, the contact lens including a tapered reflective surface to direct the beam of light into the eye of the subject.

摘要翻译： 一种用于获得对被摄体的眼睛的低角度圆周光学访问的系统。 该系统包括产生光束的光源; 光束转向机构，用于将光束转向聚焦透镜以聚焦光束; 以及隐形眼镜以将光束引导到被检体的眼睛中，该隐形眼镜包括锥形反射表面，以将光束引导到被检体的眼睛中。

公开(公告)号：US10238279B2

公开(公告)日：2019-03-26

申请号：US15547537

申请日：2016-02-05

申请人： Duke University

发明人： Joseph A. Izatt ,  Liangbo Shen ,  Oscar M. Carrasco-Zevallos ,  Cynthia Toth

IPC分类号： A61B3/00 ,  G02B21/00 ,  G02B21/22 ,  A61B3/10 ,  A61B3/13 ,  G02B27/01 ,  H04N13/344 ,  H04N13/293 ,  H04N13/286

摘要： Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion, and configured to display second images in the second display portion. The first image and the second image are projected along a first pathway and a second pathway. The system includes a first optical element positioned to relay the first images into the first eyepiece. The system includes a second optical element positioned to relay the second images into the second eyepiece.

公开(公告)号：US20180296087A1

公开(公告)日：2018-10-18

申请号：US15569482

申请日：2016-05-05

申请人： Duke University

发明人： Oscar M. Carrasco-Zevallos ,  Justin Migacz ,  Cynthia A. Toth ,  Joseph A. Izatt

IPC分类号： A61B3/10 ,  G01B9/02

摘要： Systems and methods for long working distance optical coherence tomography (OCT). According to an aspect, an OCT system includes a reference arm. Further, the OCT system includes a sample arm operably connected to the reference arm. The sample arm includes a scanner configured to scan an optical beam. The sample arm also includes an objective positioned a predetermined distance from the scanner, configured to receive the optical beam, and to direct the optical beam to an object positioned at about the predetermined distance from the scanner for imaging of the object.

公开(公告)号：US20180271367A1

公开(公告)日：2018-09-27

申请号：US15547547

申请日：2016-02-05

申请人： Duke University

发明人： Joseph A. Izatt ,  Francesco Larocca ,  Theodore Dubose ,  Derek Nankivil

IPC分类号： A61B3/12 ,  A61B3/13 ,  A61B3/10

CPC分类号： A61B3/1208 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/13

摘要： Compact telescope configurations for light scanning systems and related methods are disclosed. According to an aspect, a system for imaging or relaying an image of an object includes a first optical element having a first focal length f1 for imaging or relaying an image of an object at the distance f1 from the first optical element. The system also includes a second optical element having a second focal length f2 for receiving an image of the object from the first optical element and for focusing an output of the image at the distance f2 from the second optical element on a side that opposes the first optical element. The first optical element and the second optical element are separated by a distance of approximately [Formula I], wherein r is the finite radius of curvature of the wavefront of light located at the object or image of the object.

公开(公告)号：US09517006B2

公开(公告)日：2016-12-13

申请号：US14372599

申请日：2013-01-24

申请人： Duke University

发明人： Joseph A. Izatt ,  Anthony N. Kuo ,  Ryan P. McNabb

IPC分类号： A61B3/10 ,  G01B9/02 ,  A61B3/117

CPC分类号： A61B3/102 ,  A61B3/117 ,  A61B3/1225 ,  A61B3/125 ,  A61B3/14 ,  A61F9/0008 ,  A61F9/00814 ,  A61F9/00827 ,  A61F2009/00851 ,  A61F2009/00863 ,  A61F2009/00868 ,  A61F2009/00891 ,  A61F2009/00897 ,  G01B9/02004 ,  G01B9/02058 ,  G01B9/02091 ,  G01B2290/65

摘要： A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam of light a focusing lens to focus the beam of light; and a contact lens to direct the beam of light into the eye of the subject, the contact lens including a tapered reflective surface to direct the beam of light into the eye of the subject.

摘要翻译： 一种用于获得对被摄体的眼睛的低角度圆周光学访问的系统。 该系统包括产生光束的光源; 光束转向机构，用于将光束转向聚焦透镜以聚焦光束; 以及隐形眼镜以将光束引导到被检体的眼睛中，该隐形眼镜包括锥形反射表面，以将光束引导到被检体的眼睛中。

公开(公告)号：US20140241605A1

公开(公告)日：2014-08-28

申请号：US13999539

申请日：2014-03-07

申请人： DUKE UNIVERSITY

发明人： Joseph A. Izatt ,  Mingtao Zhao ,  Anthony N. Kuo

IPC分类号： G06T15/00 ,  G06T5/00

CPC分类号： G06T15/00 ,  A61B3/102 ,  G01B9/02083 ,  G01B9/02091 ,  G01B11/2441 ,  G06F19/00 ,  G06T5/006 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.