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公开(公告)号:US5124136A
公开(公告)日:1992-06-23
申请号:US543634
申请日:1990-06-26
申请人: Mark E. Davis
发明人: Mark E. Davis
CPC分类号: C01B37/06 , B01J29/84 , C01B37/04 , C01B37/08 , Y10S423/30
摘要: Crystalline metalloaluminophosphate compositions having pore windows formed by 18 tetrahedral members are prepared from a forming mixture containing sources of aluminum, phosphorus and a non-aluminum, non-phosphorus element, e.g. boron or boron and silicon. The forming mixture further contains a directing agent comprising a mixture of quaternary nitrogen compound and amine in a molar ratio of 0.01 to 0.025.
摘要翻译: 由含有铝,磷和非铝,非磷元素的形成混合物制备具有由18个四面体成分形成的孔窗的结晶金属铝磷酸盐组合物,例如, 硼或硼和硅。 形成混合物还含有包含季氮化合物和胺的混合物的导向剂,摩尔比为0.01至0.025。
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公开(公告)号:US09363770B2
公开(公告)日:2016-06-07
申请号:US12119643
申请日:2008-05-13
申请人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
发明人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
CPC分类号: H04W52/343
摘要: Automatic provisioning of an access point base station or femtocell. The method may include the femtocell transmitting first information (e.g., location information, signal measurement information, capability information, etc.) to a service provider (e.g., over an IP network). The femtocell may receive second information from the service provider, where the second information includes one or more operational parameters. The operational parameters may include hand-off parameters, admission policy parameters, PN or scrambling codes, power parameters, and/or other parameters. The femtocell may operate according to the received parameters to provide access for a plurality of access terminals in a local area.
摘要翻译: 自动提供接入点基站或毫微微小区。 该方法可以包括毫微微小区向服务提供商(例如,通过IP网络)发送第一信息(例如,位置信息,信号测量信息,能力信息等)。 毫微微小区可以从服务提供商接收第二信息,其中第二信息包括一个或多个操作参数。 操作参数可以包括切换参数,准入策略参数,PN或扰码,功率参数和/或其他参数。 毫微微小区可以根据所接收的参数进行操作,以便为局域中的多个接入终端提供接入。
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公开(公告)号:US08680202B2
公开(公告)日:2014-03-25
申请号:US13572294
申请日:2012-08-10
申请人: Jianjun Cheng , Mark E. Davis , Kay T. Khin
发明人: Jianjun Cheng , Mark E. Davis , Kay T. Khin
CPC分类号: C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
摘要翻译: 本发明涉及设计为小分子治疗剂递送载体的治疗性环糊精含有聚合物的组合物及其药物组合物。 这些含环糊精的聚合物改善药物稳定性和溶解性,并且在体内使用时降低小分子治疗剂的毒性。 此外,通过从各种接头基团和靶向配体中选择,聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。 本发明还涉及用于进行药物业务的方法,包括制造,许可或分发包含或涉及本文所述的聚合物的试剂盒。
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公开(公告)号:US20130184453A1
公开(公告)日:2013-07-18
申请号:US13586166
申请日:2012-08-15
IPC分类号: C08B37/16
CPC分类号: C08G75/06 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08G69/40 , C08G69/48 , C08G73/02 , C08G73/06
摘要: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.
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公开(公告)号:US08389499B2
公开(公告)日:2013-03-05
申请号:US13553400
申请日:2012-07-19
申请人: Jianjun Cheng , Mark E. Davis , Kay T. Khin
发明人: Jianjun Cheng , Mark E. Davis , Kay T. Khin
IPC分类号: A61K31/337 , C08G2/30 , C08G69/08 , C08G69/10 , C08L5/16
CPC分类号: C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
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公开(公告)号:US08248923B2
公开(公告)日:2012-08-21
申请号:US12119581
申请日:2008-05-13
申请人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
发明人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
IPC分类号: G01R31/08
CPC分类号: H04L41/0806 , H04L41/082 , H04W12/08 , H04W24/00 , H04W84/045
摘要: Automatic provisioning of an access point base station or femtocell. The method may include the femtocell transmitting first information (e.g., location information, signal measurement information, capability information, etc.) to a service provider (e.g., over an IP network). The femtocell may receive second information from the service provider, where the second information includes one or more operational parameters. The operational parameters may include hand-off parameters, admission policy parameters, PN or scrambling codes, power parameters, and/or other parameters. The femtocell may operate according to the received parameters to provide access for a plurality of access terminals in a local area.
摘要翻译: 自动提供接入点基站或毫微微小区。 该方法可以包括毫微微小区向服务提供商(例如,通过IP网络)发送第一信息(例如,位置信息,信号测量信息,能力信息等)。 毫微微小区可以从服务提供商接收第二信息,其中第二信息包括一个或多个操作参数。 操作参数可以包括切换参数,准入策略参数,PN或扰码,功率参数和/或其他参数。 毫微微小区可以根据所接收的参数进行操作,以便为局域中的多个接入终端提供接入。
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公开(公告)号:US08223683B2
公开(公告)日:2012-07-17
申请号:US12123767
申请日:2008-05-20
申请人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
发明人: Stanislaw Czaja , Mark E. Davis , Anthony Lee , Sang Gook Kim , Li-Hsiang Sun
CPC分类号: H04W24/02 , H04W64/003 , H04W84/045
摘要: Automatic provisioning of an access point base station or femtocell. The method may include the femtocell transmitting first information (e.g., location information, signal measurement information, capability information, etc.) to a service provider (e.g., over an IP network). The femtocell may receive second information from the service provider, where the second information includes one or more operational parameters. The operational parameters may include hand-off parameters, admission policy information, PN or scrambling codes, power parameters, and/or other parameters. The femtocell may operate according to the received parameters to provide access for a plurality of access terminals in a local area.
摘要翻译: 自动提供接入点基站或毫微微小区。 该方法可以包括毫微微小区向服务提供商(例如,通过IP网络)发送第一信息(例如,位置信息,信号测量信息,能力信息等)。 毫微微小区可以从服务提供商接收第二信息,其中第二信息包括一个或多个操作参数。 操作参数可以包括切换参数,准入策略信息,PN或扰码,功率参数和/或其他参数。 毫微微小区可以根据所接收的参数进行操作,以便为局域中的多个接入终端提供接入。
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公开(公告)号:US08114983B2
公开(公告)日:2012-02-14
申请号:US12384475
申请日:2009-04-03
CPC分类号: C12N15/113 , A61K31/713 , C12N2310/14
摘要: The present invention relates to inhibitors of endothelial PAS domain protein 1 (EPAS1), and methods and compositions related to the EPAS1 inhibitors. In certain embodiments, the EPAS1 inhibitors include nucleic acids, such as for example siRNAs.
摘要翻译: 本发明涉及内皮细胞PAS结构域蛋白1(EPAS1)的抑制剂,以及与EPAS1抑制剂相关的方法和组合物。 在某些实施方案中,EPAS1抑制剂包括核酸,例如siRNA。
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公开(公告)号:US20120011678A1
公开(公告)日:2012-01-19
申请号:US13243844
申请日:2011-09-23
申请人: Mark E. Davis , John M. Davis
发明人: Mark E. Davis , John M. Davis
CPC分类号: A63D5/10
摘要: A bowling lane maintenance machine has its operating functions designed and controlled in such a manner that the machine may be battery-operated without loss of performance. Included in the operation are special movements of the machine at the pin deck to flick moisture off blades of the squeegee assembly and limited activation of the vacuum motor to reduce battery drain.
摘要翻译: 保龄球道维护机具有设计和控制的操作功能,使得机器可以在不损失性能的情况下进行电池供电。 操作中包括机器在销甲板处的特殊运动,以从刮板组件的叶片上抽出湿气,并限制真空电机的启动以减少电池消耗。
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110.
公开(公告)号:US20110294998A1
公开(公告)日:2011-12-01
申请号:US13198403
申请日:2011-08-04
申请人: Mark E. Davis , Jungyeon Hwang , Tianyi Ke , Ching-Jou Lim , Thomas Schluep
发明人: Mark E. Davis , Jungyeon Hwang , Tianyi Ke , Ching-Jou Lim , Thomas Schluep
IPC分类号: C08B37/16
CPC分类号: A61K47/61 , A61K47/65 , A61K47/6939 , A61K47/6951 , B82Y5/00
摘要: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.
摘要翻译: 本发明涉及包含与治疗剂共价连接的聚合物部分的新型组合物,其中治疗剂通过系链连接到聚合物部分。 通过从各种系链组和靶向配体中选择,聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。
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