公开(公告)号：US20070258903A1

公开(公告)日：2007-11-08

申请号：US11416860

申请日：2006-05-02

Applicant: Lothar Kleiner ,  Syed Hossainy ,  Irina Astafieva ,  Stephen Pacetti ,  Thierry Glauser ,  Jessica DesNoyer ,  Florian Ludwig

Inventor： Lothar Kleiner ,  Syed Hossainy ,  Irina Astafieva ,  Stephen Pacetti ,  Thierry Glauser ,  Jessica DesNoyer ,  Florian Ludwig

IPC: A61K39/00 ,  A61K49/10

CPC classification number: A61K9/0019 ,  A61K9/143 ,  A61K9/1611 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/602

Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.

Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。

公开(公告)号：US20070254012A1

公开(公告)日：2007-11-01

申请号：US11413404

申请日：2006-04-28

Applicant: Florian Ludwig ,  Irina Astafieva ,  David Gale ,  Syed Hossainy

Inventor： Florian Ludwig ,  Irina Astafieva ,  David Gale ,  Syed Hossainy

IPC: A61F2/02

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/61 ,  B23K2103/42 ,  B23K2103/50

Abstract: The invention provides for a stent for implanting in a bodily lumen comprising a degradable structural element including: an abluminal layer comprising an active agent; and a luminal layer, wherein the abluminal layer has a faster degradation rate than the luminal layer.

Abstract translation: 本发明提供一种用于植入体内的支架，其包括可降解结构元件，包括：包含活性剂的外膜层; 以及腔层，其中所述囊膜层具有比内腔层更快的降解速率。

公开(公告)号：US20070243256A1

公开(公告)日：2007-10-18

申请号：US11405976

申请日：2006-04-17

Applicant: Lothar Kleiner ,  Syed Hossainy ,  Stephen Pacetti ,  Jessica DesNoyer

Inventor： Lothar Kleiner ,  Syed Hossainy ,  Stephen Pacetti ,  Jessica DesNoyer

IPC: A61K31/4745 ,  A61K31/337 ,  C08G69/48 ,  C08G63/91 ,  A61K9/14

CPC classification number: A61K47/48207 ,  A61K9/0024 ,  A61K9/08 ,  A61K9/10 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/34 ,  A61K47/593 ,  A61K47/595 ,  A61K47/60 ,  C08L77/12 ,  C08L2205/02 ,  C08L2666/20

Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 也描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。

公开(公告)号：US20070202147A1

公开(公告)日：2007-08-30

申请号：US11365549

申请日：2006-02-28

Applicant: Lothar Kleiner ,  Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy

Inventor： Lothar Kleiner ,  Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy

IPC: A61F2/02 ,  A61K38/44 ,  A61K31/56 ,  A61K31/4745 ,  A61K31/337

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02

Abstract: A method of forming a coating on a medical device having a controlled morphology is described.

Abstract translation: 描述了在具有受控形态的医疗装置上形成涂层的方法。

公开(公告)号：US20070191938A1

公开(公告)日：2007-08-16

申请号：US11784917

申请日：2007-04-09

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61F2/06

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0001 ,  A61F2250/0068

Abstract: The invention is directed to an implantable device, such as a stent, for delivering a therapeutic substance. The device includes a reservoir containing a therapeutic substance and an energy converter to cause the release of the substance.

公开(公告)号：US20070128246A1

公开(公告)日：2007-06-07

申请号：US11295956

申请日：2005-12-06

Applicant: Syed Hossainy ,  Florian Ludwig ,  Srinivasan Sridharan ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Florian Ludwig ,  Srinivasan Sridharan ,  Stephen Pacetti

IPC: A61F2/02 ,  B05D3/00

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/02 ,  B05D3/0254 ,  B05D3/067 ,  B05D3/068

Abstract: Provided herein are medical device having a coating substantially free from effects of drying kinetics and methods of forming the coating.

Abstract translation: 本文提供了具有基本上没有干燥动力学影响的涂层和形成涂层的方法的医疗装置。

公开(公告)号：US20070026131A1

公开(公告)日：2007-02-01

申请号：US11527826

申请日：2006-09-26

Applicant: Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

Inventor： Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

IPC: B05D5/00 ,  A61F2/82

CPC classification number: A61F2/844 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

公开(公告)号：US20070020382A1

公开(公告)日：2007-01-25

申请号：US11527971

申请日：2006-09-26

Applicant: Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

Inventor： Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

IPC: A61L33/00

CPC classification number: A61F2/844 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

公开(公告)号：US20070020312A1

公开(公告)日：2007-01-25

申请号：US11186030

申请日：2005-07-20

Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner ,  Syed Hossainy

Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner ,  Syed Hossainy

IPC: A61L33/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/41 ,  A61L2300/604 ,  C08L77/12

Abstract: The present invention relates to methods of controlling the loading of a bioactive agent into a polymeric carrier to be coated on an implantable medical device to achieve controlled release of the bioactive agent.

Abstract translation: 本发明涉及控制将生物活性剂负载到待涂覆在可植入医疗装置上的聚合物载体中以实现生物活性剂的受控释放的方法。

公开(公告)号：US20060246209A1

公开(公告)日：2006-11-02

申请号：US11395014

申请日：2006-03-31

Applicant: Andrew McNiven ,  Thomas Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed Hossainy

Inventor： Andrew McNiven ,  Thomas Esbeck ,  Ni Ding ,  Stephen Pacetti ,  Syed Hossainy

IPC: A61L33/00

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  B05D3/107

Abstract: A method for modifying a polymeric coating on an implantable medical device, such as a stent, is disclosed. The method includes application of a fluid to a wet or dry polymeric coating with and without drugs.

Abstract translation: 公开了一种用于修改可植入医疗装置（例如支架）上的聚合物涂层的方法。 该方法包括将液体施用于具有和不具有药物的湿或干燥聚合物涂层。