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101.
公开(公告)号:US20230332180A1
公开(公告)日:2023-10-19
申请号:US18297808
申请日:2023-04-10
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip Tai , Manish Muhuri , Wei Zhan
IPC: C12N15/86 , C12N15/113 , A61K31/7088
CPC classification number: C12N15/86 , C12N15/113 , A61K31/7088 , C12N2330/51 , C12N2750/14143 , C12N2310/141 , C12N2320/32 , C12N2750/14171
Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.
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公开(公告)号:US20230332179A1
公开(公告)日:2023-10-19
申请号:US18053407
申请日:2022-11-08
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , C12N15/864 , C12N15/113 , A61K38/50 , A61K31/713 , A61K48/00 , C12N9/80 , A61P25/00 , C12N7/00
CPC classification number: C12N15/86 , C12N15/8645 , C12N15/1137 , A61K38/50 , A61K31/713 , A61K48/0075 , C12N9/80 , C12Y305/01015 , A61P25/00 , C12N7/00 , A61K48/0058 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12N15/635
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US11767539B2
公开(公告)日:2023-09-26
申请号:US16612497
申请日:2018-05-11
Applicant: University of Massachusetts
Inventor: Jun Xie , Guangping Gao
IPC: C12N15/86 , C12N15/113 , C12Q1/68
CPC classification number: C12N15/86 , C12N15/113 , C12N2310/141 , C12N2740/15043 , C12N2740/15052 , C12N2750/14143 , C12N2750/14152
Abstract: In some aspects, the disclosure relates to methods for improving titer and yield of viral vector production. In some embodiments, the methods comprise transient silencing of transgene expression during packaging of a viral vector.
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公开(公告)号:US11674154B2
公开(公告)日:2023-06-13
申请号:US17541141
申请日:2021-12-02
Applicant: University of Massachusetts
Inventor: Jae-Hyuck Shim , Guangping Gao , Jun Xie , Yeon-Suk Yang , Jung min Kim , Sachin Chaugule
CPC classification number: C12N15/86 , A61K38/45 , A61K48/0066 , A61P19/08 , C12N9/22 , C12N15/111 , C12Y207/1103 , C12N2310/141 , C12N2310/20 , C12N2320/34 , C12N2750/14143 , C12N2830/008
Abstract: In some aspects, the disclosure relates to compositions and methods for treating fibrodysplasia ossificans progressiva (FOP) in a subject. In some aspects, the disclosure provides isolated nucleic acids, and vectors such as rAAV vectors, configured to express transgenes that inhibit (e.g., decrease) expression of mutated AVCR1 gene in muscle cells or connective tissues.
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公开(公告)号:US11655483B2
公开(公告)日:2023-05-23
申请号:US17581306
申请日:2022-01-21
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip Tai , Manish Muhuri , Wei Zhan
IPC: C12N15/86 , A61K31/7088 , C12N15/113
CPC classification number: C12N15/86 , A61K31/7088 , C12N15/113 , C12N2310/141 , C12N2320/32 , C12N2330/51 , C12N2750/14143 , C12N2750/14171
Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.
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公开(公告)号:US20230057380A1
公开(公告)日:2023-02-23
申请号:US17779793
申请日:2020-11-25
Inventor: Guangping Gao , Phillip Tai , Claudio Punzo , Zunhong Ke
Abstract: Aspects of the disclosure relate to a recombinant adeno-virus encoding an anti-Vascular endothelial cell growth factor (VEGF) agent in a cell or subject (e.g., rAAV2.7m8-KH902). In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.
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公开(公告)号:US11478529B2
公开(公告)日:2022-10-25
申请号:US16815356
申请日:2020-03-11
Applicant: University of Massachusetts
Inventor: Michael R. Green , Guangping Gao , Manas Kumar Santra , Sanchita Bhatnagar
Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
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108.
公开(公告)号:US20220332792A1
公开(公告)日:2022-10-20
申请号:US17639962
申请日:2020-09-03
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip Tai , Claudio Punzo
Abstract: Aspects of the disclosure relate to compositions and methods for expressing one or more anti-Vascular endothelial cell growth factor (VEGF) agents in a cell or subject. In some embodiments, the disclosure provides isolated nucleic acids and rAAVs comprising a transgene encoding an anti-VEGF agent (e.g., KH902) and one or more regulatory sequences. In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.
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公开(公告)号:US11426469B2
公开(公告)日:2022-08-30
申请号:US15769953
申请日:2016-10-21
Applicant: University of Massachusetts
Inventor: Guangping Gao , Jianzhong Ai , Hong Li , Qiang Wei
IPC: A61K48/00 , C12N15/86 , C12N5/10 , C07K14/075 , C07K14/005 , A61K9/00 , A61K38/17 , A61P35/00 , C07K14/47
Abstract: The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
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公开(公告)号:US11421230B2
公开(公告)日:2022-08-23
申请号:US16908798
申请日:2020-06-23
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip D. Zamore , Jun Xie
IPC: C12N15/113 , C12N15/86 , A61P25/00 , A61P3/04 , A61P1/14 , A61P31/12 , A61P25/20 , A61K48/00 , C12Q1/68 , C12N7/00 , C12Q1/6897
Abstract: The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
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