公开(公告)号：US20120242257A1

公开(公告)日：2012-09-27

申请号：US13447187

申请日：2012-04-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04 ,  H05H13/00

CPC classification number: H05H13/04 ,  H05H7/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

公开(公告)号：US20110196223A1

公开(公告)日：2011-08-11

申请号：US13087096

申请日：2011-04-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61B6/00 ,  G01N23/04 ,  A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for charged particle tomographic imaging using a tomography system. The tomography imaging system is optionally simultaneously operational with a charged particle cancer therapy system using common elements, allows tomographic imaging with rotation of the patient, is operational on a patient in an upright, semi-upright, and/or horizontal position, is simultaneously operational with X-ray imaging, and/or allows use of adaptive charged particle cancer therapy. The common tomography and cancer therapy apparatus elements are operational in a multi-axis and/or multi-field raster beam mode.

Abstract translation: 本发明涉及使用断层摄影系统的带电粒子断层成像的方法和装置。 层析成像系统可选地与使用共同元件的带电粒子癌治疗系统同时操作，允许患者旋转的层析成像在直立，半直立和/或水平位置的患者上操作，同时操作 通过X射线成像，和/或允许使用适应性带电粒子癌症治疗。 常见的断层摄影和癌症治疗装置元件在多轴和/或多场光栅束模式中可操作。

公开(公告)号：US20110184221A1

公开(公告)日：2011-07-28

申请号：US13041365

申请日：2011-03-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam.

Abstract translation: 该系统使用具有延长寿命的X射线成像系统。 此外，该系统使用位于与粒子束癌治疗系统的带电粒子束路径基本相同的路径中的X射线束。 该系统产生电子束，该电子束撞击位于带电粒子束路径附近的X射线产生源。 通过在带电粒子束路径附近产生X射线，产生与带电粒子束路径并联并且/或基本上与带电粒子束路径接触的X射线路径。 然后系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 由于X射线路径基本上是带电粒子束路径，所以生成的图像可用于以带电粒子束精确地靶向肿瘤。

公开(公告)号：US20110118529A1

公开(公告)日：2011-05-19

申请号：US12985039

申请日：2011-01-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N5/1048 ,  A61N5/1082 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field raster beam charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, beam movement velocity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.

Abstract translation: 本发明涉及一种治疗实体性癌症的方法和装置。 更具体地，本发明包括多轴和/或多场光栅束带电粒子癌治疗系统。 该系统独立地控制患者平移位置，患者旋转位置，二维束轨迹，递送的束能，递送的束强度，束移动速度，带电粒子传递的时间和/或辐射进入健康组织的分布。 该系统与负离子束源，同步加速器，患者定位，成像和/或靶向方法和装置一起操作，以在分布辐射进入健康组织的同时向肿瘤递送有效且均匀的辐射。

公开(公告)号：US20100133446A1

公开(公告)日：2010-06-03

申请号：US12564367

申请日：2009-09-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J37/10 ,  H01J3/14 ,  A61N5/10

CPC classification number: A61N5/10 ,  A61N5/1082 ,  A61N2005/1087 ,  G21K1/08 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises an ion beam focusing method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The ion beam focusing system includes two or more electrodes where one electrode of each electrode pair partially obstructs the ion beam path with conductive paths, such as a conductive mesh. In a given electrode pair, electric field lines, running between the conductive mesh of a first electrode and a second electrode, provide inward forces focusing the negative ion beam. Multiple such electrode pairs provide multiple negative ion beam focusing regions.

Abstract translation: 本发明包括用作离子束注入系统的一部分的离子束聚焦方法和装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 离子束聚焦系统包括两个或更多个电极，每个电极对的一个电极部分地阻挡具有导电路径的离子束路径，例如导电网。 在给定的电极对中，在第一电极和第二电极的导电网之间延伸的电场线提供聚集负离子束的向内的力。 多个这样的电极对提供多个负离子束聚焦区域。

公开(公告)号：US20100133444A1

公开(公告)日：2010-06-03

申请号：US12558504

申请日：2009-09-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  H01J37/20 ,  H01J3/26 ,  H01J3/08

CPC classification number: A61N5/1049 ,  A61N5/10 ,  A61N5/1082 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a patient positioning method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The patient positioning system is used to translate the patient and/or rotate the patient into a zone where the proton beam can scan the tumor using a targeting system. The patient positioning system is optionally used in conjunction with systems used to constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的患者定位方法和装置。 患者定位系统用于翻译患者和/或将患者旋转到质子束可以使用靶向系统扫描肿瘤的区域。 患者定位系统可选地与用于限制患者的运动的系统结合使用，例如半垂直，坐着或铺设定位系统。

公开(公告)号：US20100127184A1

公开(公告)日：2010-05-27

申请号：US12687387

申请日：2010-01-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14

CPC classification number: A61N5/107 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，描述了用于向肿瘤有效辐射剂量递送的方法和装置。 优选地，辐射通过入口点递送到肿瘤中，并且布拉格峰值能量被靶向肿瘤的远端或远侧与进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 光束强度与辐射剂量传递效率成正比。 具有针对每个照射方向的肿瘤远侧的能级的多场照射过程提供均匀且有效的带电粒子辐射剂量递送至肿瘤。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。

公开(公告)号：US20100060209A1

公开(公告)日：2010-03-11

申请号：US12619278

申请日：2009-11-16

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H9/00

CPC classification number: H05H7/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a radio-frequency accelerator method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. An RF synthesizer provides a low voltage RF signal, that is synchronized to the period of circulation of protons in the proton beam path, to a set of integrated microcircuits, loops, and coils where the coils circumferentially enclose the proton beam path in a synchrotron. The integrated components combine to provide an accelerating voltage to the protons in the proton beam path in a size compressed and price reduced format. The integrated RF-amplifier microcircuit/accelerating coil system is operable from about 1 MHz, for a low energy proton beam, to about 15 MHz, for a high energy proton beam.

Abstract translation: 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的射频加速器方法和装置。 RF合成器提供与质子束路径中的质子循环周期同步的低电压RF信号到一组集成的微电路，环路和线圈，其中线圈周向地包围同步加速器中的质子束路径。 集成组件结合在质量压缩和价格降低的格式中为质子束路径中的质子提供加速电压。 对于高能量质子束，集成的RF放大器微电路/加速线圈系统可操作于约1MHz，对于低能量质子束至约15MHz。

公开(公告)号：US20090309520A1

公开(公告)日：2009-12-17

申请号：US12545815

申请日：2009-08-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H15/00

CPC classification number: H05H13/04 ,  H05H7/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转动磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈，平面入射磁场表面和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减少 即使在从同步加速器提取质子的过程中，所需磁场的尺寸也能直接降低所需的工作功率，并允许同步加速器中质子的持续加速。

公开(公告)号：US09757594B2

公开(公告)日：2017-09-12

申请号：US14246803

申请日：2014-04-07

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H01J37/141 ,  G21K1/093 ,  G21K5/04 ,  H05H7/00

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

Abstract: A rotatable targeting magnet apparatus and method of use thereof is described where the rotatable targeting magnet rotates independently of a beamline arc at the end of the beamline arc, where the arc is after an accelerator and before the patient in a cancer therapy system. The rotatable targeting magnet directs the charged particle beam, such as vertically, using applied current to the targeting magnet while rotation of the magnet allows scanning across the tumor. Rotation of the patient relative to the charged particle allows distribution of trailing Bragg peak energy within and/or circumferentially about the tumor.