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公开(公告)号：US10283936B2
公开(公告)日：2019-05-07
申请号：US14814426
申请日：2015-07-30
发明人： Guthrie Partridge
摘要： An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically biased. The electrical bias of the first gain chip is independent of the electrical bias of the second gain chip. The external cavity has a tunable wavelength selective filter that is changed in response to a control signal. Light in the external cavity passes through the gain chip assembly. The controller determines the tunable wavelength selective filter, and the electrical bias of each of the gain chips so as to cause the apparatus to lase at a wavelength specified by a control signal to the controller.
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102.发明授权公开(公告)号：US10279294B2
公开(公告)日：2019-05-07
申请号：US14123191
申请日：2012-06-01
摘要： An apparatus, process, and system are disclosed that effectively provide separation of a combined gas/liquid flow stream into its separated gas and liquid factions. The invention is primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE), but will have other utilization and applicability where phases of dramatically different density, viscosity and volumetric flow require separation.
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公开(公告)号：US10265733B2
公开(公告)日：2019-04-23
申请号：US15800995
申请日：2017-11-01
发明人： Robert Kincaid , Melanie Tory , Joachim Schmid
摘要： An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated object is to be moved. In one aspect of the invention, the display surface includes an area adapted for positioning a receiver for the objects. The display surface provides an indication of a position in the receiver at which the one of the objects is to be placed.
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公开(公告)号：US10209259B2
公开(公告)日：2019-02-19
申请号：US14664709
申请日：2015-03-20
IPC分类号： B01L3/00 , G01N33/00 , G01N33/68 , F16K99/00 , G01N27/447 , G01N30/46 , G01N30/60 , G01N30/72 , B01D15/08 , G01N1/40 , G01N30/08 , H01J49/00
摘要： Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.
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公开(公告)号：US10173148B2
公开(公告)日：2019-01-08
申请号：US14595183
申请日：2015-01-12
发明人： Ansgar Waldbaur , Armin Steinke
摘要： A pre-heater assembly (90) for pre-heating a fluid, in particular in a fluid separation apparatus (10), wherein the pre-heater assembly (90) comprises a capillary (200) having a lumen and being configured for conducting the fluid, and a thermal coupling body (202) contacting at least part of the capillary (200), having a value of the thermal conductivity in a range between 8 W/(m K) and 100 W/(m K) and being arrangable so that heat generated by a heat source (80) is supplied to the capillary (200) via at least part of the thermal coupling body (202).
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公开(公告)号：US20190004300A1
公开(公告)日：2019-01-03
申请号：US15418612
申请日：2017-01-27
发明人： Andrew Ghetler , Richard P. Tella
摘要： A scanning apparatus having a stage adapted to hold a specimen to be imaged and to move the specimen in a first direction, and a light source that includes a tunable laser that generates a light beam having an illumination wavelength that varies as a function of an input signal is disclosed. The apparatus includes an imaging system having a scanning assembly that includes a focusing lens that focuses the light beam to a measurement point on the specimen, a first mirror that moves in a second direction relative to the stage such that the focusing lens maintains a fixed distance between the focusing lens and the stage, and a displacement sensor that measures a distance between the scanning assembly at a mapping point on the specimen, and a light detector that measures an intensity of light leaving the measurement point on the specimen.
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公开(公告)号：US10119638B2
公开(公告)日：2018-11-06
申请号：US14766106
申请日：2013-12-06
发明人： Ponna Peter Pa , Lindy T. Miller , Tirzah Vogels
摘要： A fluidic coupling device includes a housing, and a piston, spring, and cap insertable in the housing. The spring includes a stack of spring washers and is compressible between the cap and the the piston. The cap is threadedly engageable with the housing and movable into contact with the spring. The device may be coupled to a component in a sealed manner by inserting a ferrule between the piston and the component, inserting a conduit through the housing and into the component, and threadedly engaging the housing with the component, thereby compressing the spring and translating the piston against the ferrule. The device may enable coupling to be done manually, with minimal variation in compressive loading. The piston and spring may desensitize the device to thermal cycling effects, reducing the need for retightening.
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公开(公告)号：US10017820B2
公开(公告)日：2018-07-10
申请号：US14772064
申请日：2013-03-05
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/683 , C12Q1/6827
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/683 , C12Q2533/107
摘要： Provided herein is a method of sample analysis. In some embodiments, the method comprises hybridizing fragmented genomic DNA from a test genome with a population of first oligonucleotides of the formula V1-B-V2 in the presence of one or more second oligonucleotides; contacting the product with ligase to join the ends of the fragmented genomic DNA that are hybridized to V1 and V2 to the one or more second oligonucleotides; and subjecting the product to polymerase chain reaction conditions using amplification primers that hybridize to sites that are provided by the one or more second oligonucleotides, wherein production of a product indicates that the test genome contains a chromosomal rearrangement relative to the reference genome.
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公开(公告)号：US09972480B2
公开(公告)日：2018-05-15
申请号：US14952012
申请日：2015-11-25
发明人： Trygve Ristroph
IPC分类号： H01J49/06
CPC分类号： H01J49/063 , H01J49/062
摘要： An ion guide generates a radio frequency (RF) field to radially confine ions to an ion beam along a guide axis as the ions are transmitted through the ion guide. The effective potential of the RF field includes an alternating series of barriers and wells. Ions may be trapped in individual wells in mass-dependent order, with larger masses trapped closer to a guide exit than smaller masses. The RF field may be scanned so as to release the ions from the ion guide in mass-dependent order, with larger masses released before smaller masses. The operating conditions may be set such that ions over the entire mass range arrive at a desired downstream focal point simultaneously, for example at an accelerator of a time-of-flight analyzer.
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公开(公告)号：US09945820B2
公开(公告)日：2018-04-17
申请号：US14648065
申请日：2013-10-28
CPC分类号： G01N30/20 , B01L3/502784 , G01N30/34 , G01N30/38 , G01N2030/027 , G01N2030/207 , G01N2030/347
摘要： In a liquid chromatography system, a sample is injected into a column by flowing a solvent mixture from a mixer into the column along a solvent mixture flow path; and injecting a sample into the solvent mixture flow path downstream of the mixer. In another liquid chromatography system, a sample is injected into a column by loading an isolator fluid into a sample loop, loading a sample into the sample loop, and flowing the sample into the column as a plug in front of the isolator fluid.
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