公开(公告)号：US20210187167A1

公开(公告)日：2021-06-24

申请号：US17160527

申请日：2021-01-28

申请人： Poly-Med, Inc.

发明人： Michael Aaron Vaughn

IPC分类号： A61L27/52 ,  C08J3/075 ,  C08J3/24 ,  C08K5/20 ,  C08L33/26

摘要： A double network hydrogel consists of a first network and a second network, where the first network is, or includes, a first polymer that is formed, at least in part, of —CH2—CH(OH)— units, and the second network is, or includes, a second polymer that is formed, at least in part, of carboxyl (COOH)-containing units or salts thereof, sulfonyl (SO3H)-containing units or salts thereof, and at least one of hydroxyl (OH)-containing units or amino (NH2)-containing units, where the hydrogel may be used as a cartilage replacement.

公开(公告)号：US20210155722A1

公开(公告)日：2021-05-27

申请号：US17045672

申请日：2019-04-05

申请人： POLY-MED, INC.

发明人： Michael Aaron Vaughn ,  Prabhjot Saini

IPC分类号： C08F2/50 ,  B29C64/129 ,  G03F7/00 ,  B33Y10/00 ,  B33Y70/00 ,  C08K3/32 ,  C08K5/07 ,  C08F222/10 ,  C08K5/5313

摘要： The present disclosure is directed to methods and compositions comprising photopolymerizable compositions for use in additive manufacturing, particularly for digital light processing, stereolithography or continuous liquid interface processing.

公开(公告)号：US20210022842A1

公开(公告)日：2021-01-28

申请号：US16936209

申请日：2020-07-22

申请人： Poly-Med, Inc.

发明人： Michael Scott Taylor ,  Brian Gaerke ,  Seth Dylan McCullen ,  Ryan Andrew Borem

IPC分类号： A61F2/00 ,  B33Y80/00 ,  B33Y10/00 ,  B33Y50/02 ,  B29C64/393

摘要： Disclosed herein are medical devices comprising biocompatible substrates and one or more fixation elements, and methods for making and using the same.

公开(公告)号：US09884140B2

公开(公告)日：2018-02-06

申请号：US14615473

申请日：2015-02-06

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby ,  Shawn Peniston ,  Kimberly A. Carpenter

IPC分类号： A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L23/06

CPC分类号： A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L23/06 ,  C08L2203/12 ,  C08L67/04

摘要： A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.

公开(公告)号：US09566267B2

公开(公告)日：2017-02-14

申请号：US14714458

申请日：2015-05-18

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby ,  Georgios T. Hilas

IPC分类号： A61K31/42 ,  A61K31/4174 ,  A61K9/00 ,  A61L31/02 ,  A61L31/16 ,  A61F6/08

CPC分类号： A61K31/4174 ,  A61F6/08 ,  A61K9/0036 ,  A61K31/42 ,  A61L31/02 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/06

摘要： Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.

摘要翻译： 提供了由男性和女性使用的妇女和避孕套使用的戒指，环形网，海绵或隔膜形式的生物稳定，多用途，杀微生物的阴道内装置，其中每个装置含有有效治疗特定阴道感染的药物 同时进一步显示出选自治疗非激素避孕，性传播疾病，病毒感染和逆转录病毒感染的治疗组以及子宫颈癌治疗的组中的至少一种附加功能。

公开(公告)号：US09492593B2

公开(公告)日：2016-11-15

申请号：US12284657

申请日：2008-09-24

申请人： Shalaby W. Shalaby

发明人： Shalaby W. Shalaby

IPC分类号： A61K9/70 ,  A61B17/03 ,  A61F2/00 ,  A61L27/58 ,  A61L27/48 ,  A61L31/12 ,  A61L31/14 ,  D01D5/00 ,  A61B17/42

CPC分类号： A61L31/129 ,  A61B17/42 ,  A61B2090/0816 ,  A61F2/0063 ,  A61L27/48 ,  A61L27/58 ,  A61L31/148 ,  A61L2430/22 ,  A61L2430/38 ,  D01D5/003

摘要： Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

摘要翻译： 可吸收阻隔复合材料被设计用于根据临床用途的调节气体和水渗透性，并且由至少两个物理化学不同的组分形成，其中之一是邻接于针织网和/或静电纺丝的无纺布的膜。 根据屏障复合材料的物理化学性质，它可以用于神经和小便生物外科手术以及组织工程和/或物理屏障，以防止几种外科手术后的粘连形成。

公开(公告)号：US20160101212A1

公开(公告)日：2016-04-14

申请号：US14972252

申请日：2015-12-17

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby

IPC分类号： A61L17/10 ,  A61L17/14 ,  A61L17/12 ,  A61L17/00

CPC分类号： A61L17/105 ,  A61K9/0024 ,  A61K9/7007 ,  A61K31/335 ,  A61K31/42 ,  A61K31/74 ,  A61K31/765 ,  A61K47/30 ,  A61K47/34 ,  A61L17/00 ,  A61L17/005 ,  A61L17/06 ,  A61L17/10 ,  A61L17/12 ,  A61L17/145 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08L67/04

摘要： Suture-specific coatings having a number average molecular weight not exceeding 20 kDa, a melting temperature above 37° C., and heat of fusion exceeding 20 J/g, are formed of copolyesters of polycaprolactone or of ε-caprolactone and at least one cyclic monomer forming a segmented polyester chain initiated by a polyaxial crystalline organic compound or an amorphous polyaxial polymeric initiator and include from about 0.01 to about 10 weight percent of at least one molecularly dispersed bioactive agent.

摘要翻译： 具有数均分子量不超过20kDa，熔点高于37℃，熔化热超过20J / g的缝线特异性涂层由聚己内酯或ε-己内酯的共聚酯和至少一种 形成由多轴结晶有机化合物或无定形多轴聚合物引发剂引发的分段聚酯链的环状单体，并包括约0.01至约10重量％的至少一种分子分散的生物活性剂。

公开(公告)号：US20150246996A1

公开(公告)日：2015-09-03

申请号：US14714699

申请日：2015-05-18

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby ,  Joel T. Corbett ,  Michael Aaron Vaughn ,  David R. Ingram

IPC分类号： C08G18/73 ,  C08G18/34 ,  C08G18/32

CPC分类号： C08G18/73 ,  A61L24/0021 ,  A61L27/18 ,  A61L27/52 ,  A61L2430/06 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/4244 ,  C08G18/428 ,  C08G18/4283 ,  C08G18/44 ,  C08G18/4887 ,  C08G64/0241 ,  C08G2230/00 ,  C08L75/04

摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

公开(公告)号：US20150164663A1

公开(公告)日：2015-06-18

申请号：US14615566

申请日：2015-02-06

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby ,  Kenneth W. Clinkscales ,  Kenneth David Gray

IPC分类号： A61F2/86 ,  A61L31/04 ,  A61L31/14 ,  A61L31/18

CPC分类号： A61F2/86 ,  A61F2/04 ,  A61F2/94 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61L31/048 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/404 ,  A61L2300/416 ,  A61M25/0108 ,  A61M27/008

摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.

摘要翻译： 辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周 。

公开(公告)号：US20150151024A1

公开(公告)日：2015-06-04

申请号：US14615473

申请日：2015-02-06

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby ,  Shawn Peniston ,  Kimberly A. Carpenter

IPC分类号： A61L27/48 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L23/06 ,  C08L2203/12 ,  C08L67/04

摘要： A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.

摘要翻译： 一系列可选择性吸收/可生物降解的纤维复合材料构造包括生物稳定和可吸收/可生物降解的纱线的不同组合，其组装为最初相互依赖的承载组分，在体内最终用途中转变为显示独立的功能特性。 构建体组由两组组成，一组由高柔顺性的纤维增强复合材料制成，由多丝纱构造物增强的分段多轴共聚酯的可吸收基质，其是超高分子量聚乙烯纤维和至少一种可吸收/可生物降解的组合 纤维选自由线性分段的丙交酯共聚酯和聚（3-羟基链烷酸酯）制成的丝纤维和复丝纱，可用于矫形，颌面，泌尿，血管，疝修补和组织工程应用中，第二组由涂层和 用于疝，血管和泌尿组织修复和组织工程的无涂层，经编网眼构造物。