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1.发明申请In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers 审中-公开可吸收的可结晶聚合物的原位形成的生物活性组织粘附膜公开(公告)号：US20140377211A1
公开(公告)日：2014-12-25
申请号：US14480732
申请日：2014-09-09
申请人： Poly-Med, Inc.
IPC分类号： A61L26/00
CPC分类号： A61L26/0076 , A61F13/00 , A61K9/0014 , A61K9/0017 , A61K9/7015 , A61K31/4196 , A61K47/34 , A61L15/26 , A61L26/0019 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/602 , A61L2300/604 , A61L2430/34
摘要： An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
摘要翻译： 至少一种可吸收，低结晶度的分段共聚物的原位成膜可喷雾乙酸甲酯溶液含有至少一种生物活性剂，其表现出抗微生物，抗炎，抗病毒，麻醉，止血和/或抗肿瘤活性 。 可吸收聚合物可以是多轴共聚酯，聚醚酯和聚醚酯聚氨酯，并且其生物活性溶液可以应用于动物和人皮肤或易接近的体腔，以防止或治疗一种或多种对其中的生物活性剂敏感的病症。
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公开(公告)号：US20190167839A1
公开(公告)日：2019-06-06
申请号：US16253276
申请日：2019-01-22
申请人： Poly-Med, Inc.
IPC分类号： A61L24/04 , A61L24/00 , A61P7/04 , A61P35/00 , A61L31/16 , A61L31/14 , A61L31/04 , A61L31/06 , A61K47/34 , A61K31/65
摘要： An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
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公开(公告)号：US20150246996A1
公开(公告)日：2015-09-03
申请号：US14714699
申请日：2015-05-18
申请人： Poly-Med, Inc.
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
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4.发明申请In Situ Film-Forming Bioactive Solutions of Absorbable Multiblock Copolymers 审中-公开可吸收多嵌段共聚物的原位成膜生物活性溶液公开(公告)号：US20150150988A1
公开(公告)日：2015-06-04
申请号：US14612377
申请日：2015-02-03
申请人： Poly-Med, Inc.
IPC分类号： A61K47/34 , A61K33/38 , A61K31/155 , A61K31/4196
CPC分类号： A61K47/34 , A61F13/00 , A61K9/0014 , A61K9/0017 , A61K9/7015 , A61K31/155 , A61K31/4196 , A61K33/38 , A61K47/30 , A61L15/26 , A61L26/0019 , A61L26/0066 , A61L2300/404 , A61K2300/00
摘要： An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.
摘要翻译： 至少一种具有无定形和半结晶段的可吸收的可分段嵌段共聚物的原位成膜乙酸甲酯溶液含有至少一种生物活性剂，其显示抗微生物，抗炎，抗病毒，麻醉，止血和/或 抗肿瘤活性。 可吸收聚合物可以是多轴共聚酯，聚醚酯和聚醚酯聚氨酯。 可以将溶液（例如喷雾或擦拭）施用到动物和人类皮肤或可接近的体腔上，以防止或治疗由其中的生物活性剂可预防或治疗的一种或多种病症。
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5.发明授权In situ film-forming bioactive solutions of absorbable multiblock copolymers 有权可吸收多嵌段共聚物的原位成膜生物活性溶液公开(公告)号：US08951552B2
公开(公告)日：2015-02-10
申请号：US13687635
申请日：2012-11-28
申请人： Poly-Med, Inc.
IPC分类号： A61F13/00 , A61L15/26 , A61K47/34 , A61K47/30 , A61K9/00 , A61K9/70 , A61K31/4196 , A61L26/00 , A61K31/155 , A61K33/38
CPC分类号： A61K47/34 , A61F13/00 , A61K9/0014 , A61K9/0017 , A61K9/7015 , A61K31/155 , A61K31/4196 , A61K33/38 , A61K47/30 , A61L15/26 , A61L26/0019 , A61L26/0066 , A61L2300/404 , A61K2300/00
摘要： An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.
摘要翻译： 至少一种具有无定形和半结晶段的可吸收的可分段嵌段共聚物的原位成膜乙酸甲酯溶液含有至少一种生物活性剂，其显示抗微生物，抗炎，抗病毒，麻醉，止血和/或 抗肿瘤活性。 可吸收聚合物可以是多轴共聚酯，聚醚酯和聚醚酯聚氨酯。 可以将溶液（例如喷雾或擦拭）施用到动物和人类皮肤或可接近的体腔上，以防止或治疗由其中的生物活性剂可预防或治疗的一种或多种病症。
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6.发明授权In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers 有权可吸收的可结晶聚合物的原位形成的生物活性组织粘附膜公开(公告)号：US09402932B2
公开(公告)日：2016-08-02
申请号：US14480732
申请日：2014-09-09
申请人： Poly-Med, Inc.
CPC分类号： A61L26/0076 , A61F13/00 , A61K9/0014 , A61K9/0017 , A61K9/7015 , A61K31/4196 , A61K47/34 , A61L15/26 , A61L26/0019 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/602 , A61L2300/604 , A61L2430/34
摘要： An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
摘要翻译： 至少一种可吸收，低结晶度的分段共聚物的原位成膜可喷雾乙酸甲酯溶液含有至少一种生物活性剂，其表现出抗微生物，抗炎，抗病毒，麻醉，止血和/或抗肿瘤活性 。 可吸收聚合物可以是多轴共聚酯，聚醚酯和聚醚酯聚氨酯，并且其生物活性溶液可以应用于动物和人皮肤或易接近的体腔，以防止或治疗一种或多种对其中的生物活性剂敏感的病症。
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7.发明授权公开(公告)号：US09034361B2
公开(公告)日：2015-05-19
申请号：US14058640
申请日：2013-10-21
申请人： Poly-Med, Inc.
IPC分类号： A61F2/30 , C08G18/00 , C08G64/02 , A61L24/00 , A61L27/18 , A61L27/52 , C08G18/12 , C08G18/42 , C08G18/44 , C08G18/48 , C08G18/73
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译： 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。
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