公开(公告)号：US20190350840A1

公开(公告)日：2019-11-21

申请号：US16473119

申请日：2017-12-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Toshihiro KOGURE ,  Seiji TOKUMOTO ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K31/135 ,  A61M37/00 ,  A61K47/20 ,  A61K47/02

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

公开(公告)号：US10369115B2

公开(公告)日：2019-08-06

申请号：US14913455

申请日：2014-08-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Keiichiro Tsurushima ,  Yasuhisa Kose ,  Shinji Yamasoto ,  Seiichiro Tsuru ,  Takaaki Yoshinaga

IPC: A61K9/70 ,  A61L15/22 ,  A61L15/58 ,  A61L15/60 ,  C08L71/00 ,  C08F220/14 ,  C08L33/02

Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.

公开(公告)号：US20190046493A1

公开(公告)日：2019-02-14

申请号：US16079208

申请日：2016-10-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K31/216 ,  A61K47/14 ,  A61K47/12 ,  A61K47/02 ,  A61K9/00 ,  A61P17/00

Abstract: The present invention provides a liquid topical preparation having low “stickiness” even when it contains a high concentration of an anticholinergic drug. The liquid topical preparation comprises water, an anticholinergic drug and dicarboxylic acid ester, and the content of the anticholinergic drug ranges from 10 mass % to 20 mass % based on the total mass of the liquid topical preparation.

公开(公告)号：US20180339050A1

公开(公告)日：2018-11-29

申请号：US16056694

申请日：2018-08-07

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki SUZUKI ,  Hiroaki OKUTSU ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K47/12 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K47/10 ,  A61K31/55 ,  A61M37/00 ,  A61K31/407

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

公开(公告)号：US20180289630A1

公开(公告)日：2018-10-11

申请号：US15769393

申请日：2016-10-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi SONOBE ,  Akio TAKEUCHI ,  Yasunori TAKADA

IPC: A61K9/70 ,  A61K31/4468 ,  A61K47/22 ,  A61K47/02 ,  A61K47/14 ,  A61K47/44

CPC classification number: A61K9/7053 ,  A61K9/703 ,  A61K9/7069 ,  A61K31/4468 ,  A61K47/02 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/44

Abstract: A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule.

公开(公告)号：US10022445B2

公开(公告)日：2018-07-17

申请号：US14416983

申请日：2013-07-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K47/12 ,  A61K31/55 ,  A61K9/70

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US20170348228A1

公开(公告)日：2017-12-07

申请号：US15521101

申请日：2015-10-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC. ,  ASKA Pharmaceutical Co., Ltd.

Inventor： Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Takeshi ITO ,  Hajime ASADA

IPC: A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K38/24 ,  A61K47/12 ,  A61K47/18 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K9/00 ,  A61K38/24 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.

公开(公告)号：USD801185S1

公开(公告)日：2017-10-31

申请号：US29575323

申请日：2016-08-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC

Designer： Yui Takanishi ,  Sayaka Mochizuki

公开(公告)号：USD799051S1

公开(公告)日：2017-10-03

申请号：US29555976

申请日：2016-02-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Masayoshi Maki ,  Toshiro Yamaguchi

公开(公告)号：US09687474B2

公开(公告)日：2017-06-27

申请号：US14416964

申请日：2013-07-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K31/407 ,  A61K47/14 ,  A61K47/10 ,  A61K9/70 ,  A61K47/06 ,  A61K47/12

CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.