公开(公告)号：US20120042893A1

公开(公告)日：2012-02-23

申请号：US13266938

申请日：2010-05-26

Applicant: Thomas S. Campbell ,  Thomas J. Boyd ,  Steven W. Fisher ,  Michael Prencipe

Inventor： Thomas S. Campbell ,  Thomas J. Boyd ,  Steven W. Fisher ,  Michael Prencipe

IPC: A61K8/27 ,  A61Q11/00 ,  A61K8/81

CPC classification number: A61K8/27 ,  A61K8/345 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8164 ,  A61K8/86 ,  A61K2800/56 ,  A61K2800/592

Abstract: An oral care composition and method are described in which the composition includes a film or a plurality of film fragments entrained in a carrier. The film or plurality of film fragments comprises a zinc compound and the carrier comprises a polysaccharide and a maleic anhydride copolymer. The composition and methods provide benefits including one or more of increased consumer acceptability, improved solubility of zinc thus permitting the use of lower amounts of zinc compounds and reducing the adverse astringency associated with zinc, decreased adverse reactions brought about by the presence of zinc ions, enhanced aesthetics, improved stability for active or other functional materials, and controlled delivery of active materials such as zinc.

Abstract translation: 描述了一种口腔护理组合物和方法，其中组合物包含夹带在载体中的膜或多个膜片段。 膜或多个膜片段包含锌化合物，载体包含多糖和马来酸酐共聚物。 组合物和方法提供益处，包括一种或多种增加的消费者可接受性，改善锌的溶解度，从而允许使用较少量的锌化合物并减少与锌相关的不利涩味，减少由锌离子的存在引起的不良反应， 增强的美观性，改善活性或其它功能材料的稳定性，以及控制递送活性材料如锌。

公开(公告)号：US20090202452A1

公开(公告)日：2009-08-13

申请号：US12272257

申请日：2008-11-17

Applicant: Richard Scott Robinson ,  Richard J. Sullivan ,  Michael Prencipe ,  Rajnish Kohli ,  Isabelle Van Rycke ,  Richard Lovell ,  Sergio Leite ,  Eric A. Simon ,  Ralph Peter Santarpia, III ,  Diane Cummins ,  Sarita V. Mello ,  Suman Chopra ,  Karen J. DePierro ,  Lynette Zaidel ,  Constantina Christopoulou ,  Ravi Subramanyam ,  Donghui Wu ,  Andre M. Morgan ,  Qin Wang ,  Gary Edward Tambs ,  Virginia Monsul Barnes

Inventor： Richard Scott Robinson ,  Richard J. Sullivan ,  Michael Prencipe ,  Rajnish Kohli ,  Isabelle Van Rycke ,  Richard Lovell ,  Sergio Leite ,  Eric A. Simon ,  Ralph Peter Santarpia, III ,  Diane Cummins ,  Sarita V. Mello ,  Suman Chopra ,  Karen J. DePierro ,  Lynette Zaidel ,  Constantina Christopoulou ,  Ravi Subramanyam ,  Donghui Wu ,  Andre M. Morgan ,  Qin Wang ,  Gary Edward Tambs ,  Virginia Monsul Barnes

IPC: A61K8/66 ,  A61K8/44 ,  A61K8/97 ,  A61Q11/00 ,  A61P31/04 ,  A61K8/21

CPC classification number: A61K8/25 ,  A61K8/44 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/88 ,  A61Q11/00

Abstract: The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form and optionally contacting the oral surface with a periodic oral care cleaning composition at least once monthly. The periodic oral care cleaning compositions suitable for use in the method comprise an abrasive system.

Abstract translation: 本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。 这样的方法包括每天至少一次使口腔表面与主要口腔护理组合物接触，使口腔表面与定期的口腔护理维持组合物每月至少一次接触，其中定期口腔护理维持组合物包含游离或 任选地使口腔表面与定期的口腔护理清洁组合物每月至少一次接触。 适用于该方法的定期口腔护理清洁组合物包括研磨系统。

公开(公告)号：US20090092562A1

公开(公告)日：2009-04-09

申请号：US12275361

申请日：2008-11-21

Applicant: Lynette Zaidel ,  Suman K. Chopra ,  Michael Prencipe ,  Qin Wang ,  Constantina Christopoulou

Inventor： Lynette Zaidel ,  Suman K. Chopra ,  Michael Prencipe ,  Qin Wang ,  Constantina Christopoulou

IPC: A61K8/25 ,  A61Q11/00

CPC classification number: A61K8/04 ,  A61K8/25 ,  A61K8/8164 ,  A61K2800/412 ,  A61Q11/00

Abstract: The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule.

Abstract translation: 本发明包括减少和/或消除牙齿敏感性感觉的口腔护理组合物。 组合物包括粘附材料和具有约8微米或更小的平均粒度的颗粒。 颗粒在组合物中的存在量为约5重量％。 也包括在本发明的范围内的是相关方法，例如封闭牙本质小管的方法。

公开(公告)号：US20080213730A1

公开(公告)日：2008-09-04

申请号：US12105065

申请日：2008-04-17

Applicant: Michael Prencipe ,  Suman K. Chopra ,  Michael Collins

Inventor： Michael Prencipe ,  Suman K. Chopra ,  Michael Collins

IPC: A61C17/00

CPC classification number: A61C19/066 ,  A61K8/18 ,  A61K8/22 ,  A61K8/8176 ,  A61K8/891 ,  A61Q11/00

Abstract: A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time.

Abstract translation: 具有疏水牙齿美白配方的牙科托盘，其中牙齿美白配方基本上是非水溶性的，以及使用该牙科托盘来使牙齿变白的方法。 牙齿美白制剂主要由疏水性聚合物和过氧化物或产生过氧化物的化合物组成。 优选地，疏水性聚合物是有机硅树脂和有机硅氧烷的缩合产物。 牙托被形成为包围牙齿的前表面和后表面。 牙科托盘由热塑性或热固性聚合物组成。 将牙齿美白配制剂放入牙托中，并将放置在牙齿上的托盘白化。 这是足够的时间来至少部分地美白牙齿。 这可以是约0.5小时至2小时或更长时间。 基本上非水性牙齿美白制剂在较长时间内是有效的，因为在治疗时间内没有显着稀释或从牙盘中除去。

公开(公告)号：US20080181856A1

公开(公告)日：2008-07-31

申请号：US11668821

申请日：2007-01-30

Applicant: Michael Prencipe

Inventor： Michael Prencipe

IPC: A61K8/55 ,  A61Q11/00

CPC classification number: A61K8/27 ,  A61K8/0241 ,  A61K8/21 ,  A61K8/24 ,  A61K8/25 ,  A61K8/33 ,  A61K8/416 ,  A61K8/42 ,  A61K8/43 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/4953 ,  A61K8/4973 ,  A61K8/55 ,  A61K8/58 ,  A61K8/64 ,  A61K2800/412 ,  A61Q11/00

Abstract: The invention includes a dentifrice composition that comprises a zinc ion source, a polyphosphate ion source, an anethole, and a silica. The silica has a mean particle size of about 5 to about 12 microns, an Einlehner hardness of about 1 to about 20, and an oil absorption of about 40 to less than about 100 cc/100 g. The composition contains zinc ions and polyphosphate ions in a weight ratio of about 0.1:1 to about 10:1 and has a RDA value of about 100 to about 200 and a PCR value of about 75 to about 110. Related methods are also included.

Abstract translation: 本发明包括含有锌离子源，多磷酸盐离子源，茴香脑和二氧化硅的洁齿剂组合物。 二氧化硅具有约5至约12微米的平均粒度，约1至约20的爱因纳硬度，以及约40至小于约100cc / 100g的吸油量。 该组合物含有约0.1:1至约10:1的重量比的锌离子和多磷酸根离子，并且RDA值为约100至约200，PCR值为约75至约110.相关方法也包括在内。

公开(公告)号：US20070286820A1

公开(公告)日：2007-12-13

申请号：US11745158

申请日：2007-05-07

Applicant: Michael Prencipe ,  Isabelle Rycke ,  Richard Lovell

Inventor： Michael Prencipe ,  Isabelle Rycke ,  Richard Lovell

IPC: A61K8/18 ,  A61Q11/00

CPC classification number: A61K8/25 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/88 ,  A61K2800/884 ,  A61Q11/00

Abstract: The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100 g and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.

Abstract translation: 本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。 这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次接触，并在约42天的时间内将口腔表面与周期性口腔护理组合物接触至少一次。 适用于该方法的定期口腔护理组合物包括具有大于约5毫克损失/ 100,000次旋转的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。 在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。 定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些 大于约90cm 3 / 100g和/或Einlehner硬度小于每10万次旋转约5mg的损失。 第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。 存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和低于约100的放射性牙本质磨损 约200。

公开(公告)号：US20070071696A1

公开(公告)日：2007-03-29

申请号：US11236094

申请日：2005-09-27

Applicant: Qin Wang ,  Suman Chopra ,  Lynette Zaidel ,  Michael Prencipe

Inventor： Qin Wang ,  Suman Chopra ,  Lynette Zaidel ,  Michael Prencipe

IPC: A61K8/42 ,  A61K8/22

CPC classification number: A61K8/22 ,  A61K8/20 ,  A61K8/21 ,  A61K8/24 ,  A61K8/25 ,  A61K8/38 ,  A61K8/737 ,  A61K8/85 ,  A61K8/86 ,  A61K8/89 ,  A61K2800/88 ,  A61Q11/00

Abstract: A dual phase whitening oral care composition comprising a first phase comprising a bound peroxide in a substantially anhydrous carrier and a second phase comprising an abrasive and a tartar control system in an orally acceptably carrier. Methods of whitening a tooth surface are also provided.

Abstract translation: 双相增白口腔护理组合物，其包含在基本上无水的载体中包含结合的过氧化物的第一相和在口服可接受的载体中包含研磨剂和牙垢控制体系的第二相。 还提供了牙齿表面美白的方法。

公开(公告)号：US20060292088A1

公开(公告)日：2006-12-28

申请号：US11168681

申请日：2005-06-28

Applicant: Prithwiraj Maitra ,  Suman Chopra ,  Sayed Ibrahim ,  Eugene Pashkovski ,  Michael Prencipe

Inventor： Prithwiraj Maitra ,  Suman Chopra ,  Sayed Ibrahim ,  Eugene Pashkovski ,  Michael Prencipe

IPC: A61K8/81

CPC classification number: A61K8/19 ,  A61K8/24 ,  A61K8/26 ,  A61K8/29 ,  A61K8/8111 ,  A61K8/8123 ,  A61K8/8152 ,  A61Q11/00

Abstract: Compositions for altering the color of teeth, including tooth-coating compositions comprising a colorant and an acrylate polymer. Colorants among those useful herein include whiteness-imparting particulate materials, such as hydroxyapatite.

公开(公告)号：US20060147394A1

公开(公告)日：2006-07-06

申请号：US11285871

申请日：2005-11-23

Applicant: Ramachandra Shastry ,  Yelloji Mirajkar ,  Nagaraj Dixit ,  Ryan Cameron ,  Qin Wang ,  Lynette Zaidel ,  Suman Chopra ,  Michael Prencipe

Inventor： Ramachandra Shastry ,  Yelloji Mirajkar ,  Nagaraj Dixit ,  Ryan Cameron ,  Qin Wang ,  Lynette Zaidel ,  Suman Chopra ,  Michael Prencipe

IPC: A61K8/00

CPC classification number: A61K8/22 ,  A61K8/8152 ,  A61Q11/00

Abstract: In various embodiments, the present invention provides a tooth whitening composition comprising a peroxide composite and an orally acceptable carrier. The peroxide composite comprises a peroxide compound and a porous cross-linked polymer, preferably in the form of a microporous particulate. The peroxide compound can be sorbed onto the porous crosslinked polymer. The porous cross-linked polymer may comprise a polymerized polyunsaturated monomer selected from polyacrylates, polymethacrylates, polyitaconates, and mixtures thereof. The carrier can be non-aqueous, and can comprise a film forming material. Methods are also provided for whitening a tooth surface with the tooth whitening compositions.

Abstract translation: 在各种实施方案中，本发明提供了包含过氧化物复合物和口服可接受的载体的牙齿增白组合物。 过氧化物复合物包括过氧化物化合物和多孔交联聚合物，优选为微孔颗粒形式。 过氧化物可以吸附到多孔交联聚合物上。 多孔交联聚合物可以包含选自聚丙烯酸酯，聚甲基丙烯酸酯，多衣康酸酯及其混合物的聚合的多不饱和单体。 载体可以是非水的，并且可以包含成膜材料。 还提供了用于使牙齿美白组合物使牙齿美白的方法。

公开(公告)号：US20060141072A1

公开(公告)日：2006-06-29

申请号：US11025577

申请日：2004-12-29

Applicant: Evangelia Arvanitidou ,  Michael Prencipe

Inventor： Evangelia Arvanitidou ,  Michael Prencipe

IPC: A61K36/82 ,  A61K36/539 ,  A61K36/53 ,  A61K36/87

CPC classification number: A61K8/97 ,  A61K8/19 ,  A61K8/20 ,  A61K8/21 ,  A61K8/23 ,  A61K8/25 ,  A61K8/33 ,  A61K8/347 ,  A61K2800/28 ,  A61K2800/43 ,  A61K2800/48 ,  A61K2800/522 ,  A61Q11/00

Abstract: Low water tooth pastes contain a variety of plant extracts. The oral or dentifrice compositions containing humectants, abrasive compounds, and a variety of plant extracts, such as rosemary and green tea extracts, along with an additional antioxidant component. Examples of antioxidants include stannous compounds, sodium meta-bisulfite, BHT, ammonium sulfate, and potassium stannate. The compositions are resistant to browning. The invention also provides methods for promoting oral health of a subject animal comprising applying a composition as discussed above to the oral surfaces of the animal.

Abstract translation: 低水牙膏含有各种植物提取物。 含有湿润剂，磨料化合物和各种植物提取物如迷迭香和绿茶提取物的口服或牙粉组合物以及另外的抗氧化成分。 抗氧化剂的实例包括亚锡化合物，偏亚硫酸氢钠，BHT，硫酸铵和锡酸锡。 组合物耐褐变。 本发明还提供用于促进受试动物的口腔健康的方法，包括将如上所述的组合物施用于动物的口腔表面。