公开(公告)号：US11421025B2

公开(公告)日：2022-08-23

申请号：US15108415

申请日：2014-12-26

Applicant: OSAKA UNIVERSITY

Inventor： Hiroshi Koriyama ,  Hironori Nakagami ,  Ryuichi Morishita

IPC: A61K39/00 ,  C07K16/24

Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.

公开(公告)号：US11407871B2

公开(公告)日：2022-08-09

申请号：US16470115

申请日：2017-12-16

Applicant: EARTH CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kiyoto Takamori ,  Kei Ohkubo ,  Tsuyoshi Inoue ,  Yasushi Mizuta ,  Yuichi Itou

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08J7/12

Abstract: The present invention provides a new method by which polymers can be modified. The present invention provides a method for modifying a polymer including the step of: irradiating a reaction system containing a polymer with light to react the reaction system in a presence of a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

公开(公告)号：US20220241315A1

公开(公告)日：2022-08-04

申请号：US17596137

申请日：2020-05-29

Applicant: CancerStem Tech Inc. ,  OSAKA UNIVERSITY

Inventor： Hirofumi Yamamoto ,  Xin Wu

IPC: A61K31/713 ,  A61P35/00

Abstract: An object of the present invention is to provide a nucleic acid medicine for cancer treatment that makes it possible to treat cancer effectively. miR-4711-5p can suppress the expression of KLF5, TFDP1, and MDM2, as a result suppressing the proliferation, infiltration, and migration of cancer cells effectively, inducing apoptosis and G1 arrest, and also lowering stemness.

公开(公告)号：US20220233571A1

公开(公告)日：2022-07-28

申请号：US17613607

申请日：2020-05-22

Applicant: OSAKA UNIVERSITY

Inventor： Shigekazu NAGATA ,  Yuta RYODEN ,  Katsumori SEGAWA

IPC: A61K31/7088

Abstract: An object is to provide a P2X7 receptor expression modulator. The object is achieved by a P2X7 receptor expression modulator comprising at least one member selected from the group consisting of an Eros (essential for reactive oxygen species) expression modulator and a functional modulator of Eros.

公开(公告)号：US20220226983A1

公开(公告)日：2022-07-21

申请号：US17658166

申请日：2022-04-06

Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL ,  OSAKA UNIVERSITY

Inventor： Tomoyuki Noda ,  Yoshihiro Nakata ,  Hiroshi Ishiguro ,  Jun Morimoto

IPC: B25J9/08 ,  F16C35/06 ,  B25J13/08 ,  B25J17/00 ,  B25J9/10 ,  B25J17/02

Abstract: Provided is a modularized externally-driven joint structure that can be used for general purposes. An aspect of the present invention is directed to an externally-driven joint structure (1) including: a shaft member (13) that extends in an axial direction; and a plurality of rotatable members (11 and 12) that are arranged along the axial direction, and are coupled with each other by the shaft member in an axially rotatable manner. Each of the rotatable members includes a pair of face portions (122) that face each other in the axial direction, a side wall portion (113 or 123) that is arranged along the outer circumferential edges of the pair of face portions, and at least one coupling portion (21) that is arranged at the face portions or the side wall portion, and is coupled with a link member (31) constituting a link of a robot.

公开(公告)号：US20220221434A1

公开(公告)日：2022-07-14

申请号：US17609622

申请日：2020-05-07

Applicant: OSAKA UNIVERSITY ,  SHIMADZU CORPORATION

Inventor： Fumio MATSUDA ,  Shinji KANAZAWA

IPC: G01N30/86 ,  G06F16/33

Abstract: The present invention is an analytical device (50) including: an information acquisition unit (51) configured to acquire first identification information identifying, from a result of measuring an analyte contained in a biological sample using an analyzer (10), the analyte; an extraction unit (56) configured to extract a related term related to the analyte, from a database (41) in which document data is accumulated, on a basis of the first identification information acquired by the information acquisition unit; and a presentation unit (57, 59) configured to present the related term extracted by the extraction unit to a user.

公开(公告)号：US11377757B2

公开(公告)日：2022-07-05

申请号：US16792386

申请日：2020-02-17

Applicant: PANASONIC CORPORATION ,  OSAKA UNIVERSITY

Inventor： Yoshio Okayama ,  Shinsuke Komatsu ,  Masahiro Tada ,  Yusuke Mori ,  Masayuki Imanishi ,  Masashi Yoshimura

IPC: C30B29/40 ,  C30B15/36 ,  C30B15/00 ,  C30B19/02 ,  C30B25/18

Abstract: An object of the present invention is to provide a method for producing a group III nitride crystal in which generation of breaking or cracks is less likely to occur. To achieve the object, the method for producing a group III nitride crystal includes: seed crystal preparation including disposing a plurality of crystals of a group III nitride as a plurality of seed crystals on a substrate; and crystal growth including growing group III nitride crystals by contacting a surface of each of the seed crystals with a melt containing at least one group III element selected from gallium, aluminum, and indium and an alkali metal in an atmosphere containing nitrogen. In the seed crystal preparation, the plurality of seed crystals are disposed within a hexagonal region provided on the substrate.

公开(公告)号：US20220207425A1

公开(公告)日：2022-06-30

申请号：US17606343

申请日：2020-04-26

Applicant: Osaka University ,  PAMELA, Inc.

Inventor： Aya Nakae ,  Koutarou Nomura

IPC: G06N20/00

Abstract: The problem to be solved is to provide a system and the like for augmenting supervisory data while maintaining the relationship among a plurality supervisory data used for machine learning. The present disclosure provides a system for augmenting supervisory data used for machine learning, the system including an obtaining means that obtains a plurality of supervisory data, a first processing means that derives a covariance matrix from the plurality of supervisory data, a second processing means that decomposes the covariance matrix, and a third processing means that applies a random number to the decomposed matrix.

公开(公告)号：US11369626B2

公开(公告)日：2022-06-28

申请号：US16907913

申请日：2020-06-22

Applicant: OSAKA UNIVERSITY ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Hiroyuki Tanaka ,  Hideki Yoshikawa ,  Hideki Mochizuki ,  Tsuyoshi Murase ,  Tsutomu Sasaki ,  Kousuke Baba ,  Toru Iwahashi ,  Mitsuru Naiki

IPC: A61K31/714 ,  A61P25/28 ,  A61K9/00

Abstract: A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.

公开(公告)号：US11363948B2

公开(公告)日：2022-06-21

申请号：US16691882

申请日：2019-11-22

Applicant: OSAKA UNIVERSITY ,  TOPCON CORPORATION

Inventor： Takashi Fujikado ,  Yoko Hirohara ,  Makoto Saika ,  Suguru Miyagawa

IPC: A61B3/103 ,  A61B3/00 ,  A61B3/10 ,  A61B3/18

Abstract: An ophthalmologic device includes: a visual target presenting unit configured to present a common visual target to be viewed with both subject's eyes; a presenting distance changing unit configured to change a presenting distance of the visual target presented by the visual target presenting unit from a predetermined far vision distance to a predetermined near vision distance; an ocular characteristic acquiring unit configured to objectively acquire an optical characteristic of the subject's eyes; an addition power adding unit configured to add the addition power to the both subject's eyes; and a control unit configured to cause the presenting distance changing unit to change the presenting distance and the ocular characteristic acquiring unit to continuously acquire the optical characteristic, in a state in which an addition power is added to the both subject's eyes by the addition power adding unit.