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公开(公告)号：US11369626B2
公开(公告)日：2022-06-28
申请号：US16907913
申请日：2020-06-22
发明人： Hiroyuki Tanaka , Hideki Yoshikawa , Hideki Mochizuki , Tsuyoshi Murase , Tsutomu Sasaki , Kousuke Baba , Toru Iwahashi , Mitsuru Naiki
IPC分类号： A61K31/714 , A61P25/28 , A61K9/00
摘要： A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.
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公开(公告)号：US12029751B2
公开(公告)日：2024-07-09
申请号：US18143370
申请日：2023-05-04
发明人： Hiroyuki Tanaka , Hideki Yoshikawa , Hideki Mochizuki , Tsuyoshi Murase , Tsutomu Sasaki , Kousuke Baba , Toru Iwahashi , Mitsuru Naiki
IPC分类号： A61K31/714 , A61K9/00 , A61P25/28
CPC分类号： A61K31/714 , A61K9/0019 , A61P25/28
摘要： An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B12 as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
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公开(公告)号：US11679122B2
公开(公告)日：2023-06-20
申请号：US17748553
申请日：2022-05-19
发明人： Hiroyuki Tanaka , Hideki Yoshikawa , Hideki Mochizuki , Tsuyoshi Murase , Tsutomu Sasaki , Kousuke Baba , Toru Iwahashi , Mitsuru Naiki
IPC分类号： A61K31/714 , A61P25/28 , A61K9/00
CPC分类号： A61K31/714 , A61K9/0019 , A61P25/28
摘要： An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B12 as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
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4.发明授权公开(公告)号：US12099070B2
公开(公告)日：2024-09-24
申请号：US17425197
申请日：2020-02-03
申请人： Osaka University
发明人： Kensuke Ikenaka , Hideki Mochizuki , Cesar Aguirre Martinez , Yuji Goto , Masatomo So , Keita Kakuda , Hirotsugu Ogi , Kentaro Noi
CPC分类号： G01N33/6896 , G01N33/582 , G01N33/6845 , G01N2333/47 , G01N2800/2835
摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).
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5.发明申请公开(公告)号：US20220128576A1
公开(公告)日：2022-04-28
申请号：US17425197
申请日：2020-02-03
申请人： Osaka University
发明人： Kensuke Ikenaka , Hideki Mochizuki , Cesar Aguirre Martinez , Yuji Goto , Masatomo So , Keita Kakuda , Hirotsugu Ogi , Kentaro Noi
摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).
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公开(公告)号：US20180200277A1
公开(公告)日：2018-07-19
申请号：US15743622
申请日：2016-07-07
申请人： Osaka University
IPC分类号： A61K31/7048 , A61K31/7052 , A61P21/00
CPC分类号： A61K31/7048 , A61K31/7052 , A61P21/00
摘要： The present invention provides a therapeutic agent for myotonic dystrophy which inhibits aberrant splicing responsible for myotonic dystrophy, resulting in an increase in a normally spliced product and thus improvement in a symptom of myotonic dystrophy, and is highly safe for use in long-term administration. The therapeutic agent for myotonic dystrophy comprises, as an active ingredient, at least one compound selected from the group consisting of erythromycin, clarithromycin and azithromycin, a pharmaceutically acceptable salt or hydrate thereof, or a prodrug thereof.
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公开(公告)号：US11234995B2
公开(公告)日：2022-02-01
申请号：US16068163
申请日：2017-01-05
申请人： OSAKA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
发明人： Masayuki Nakamori , Hideki Mochizuki , Satoshi Obika , Takanori Yokota , Tetuya Nagata , Yuya Kasahara
IPC分类号： C12N15/11 , A61K31/712 , C07K14/47 , C12N15/113 , C07H21/02 , C12N15/09 , A61P25/28 , A61P25/16
摘要： The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of α-synudein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an α-synudein gene, has activity for inhibiting expression of the α-synudein gene, and is complementary to the α-synudein gene, and the oligonucleotide has a length of twelve to twenty bases.
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公开(公告)号：US11020464B2
公开(公告)日：2021-06-01
申请号：US16486768
申请日：2018-02-20
申请人： OSAKA UNIVERSITY , FUNPEP CO., LTD.
发明人： Munehisa Shimamura , Tomohiro Kawano , Hironori Nakagami , Ryuichi Morishita , Hideki Mochizuki , Akiko Tenma , Takako Ehara
摘要： Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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公开(公告)号：US11623198B2
公开(公告)日：2023-04-11
申请号：US16627086
申请日：2018-04-19
发明人： Yuji Goto , Hirotsugu Ogi , Masatomo So , Kensuke Ikenaka , Hideki Mochizuki , Shinichi Hashimoto
摘要： An ultrasound generation member according to an aspect of the present invention includes an ultrasound generation element configured to emit ultrasound in a direction of a target object in one specific container of a plurality of containers. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member, and a drive power supply configured to apply voltage across the ultrasound generation element of the ultrasound generation member. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member that includes, as the ultrasound generation element, a plurality of ultrasound generation elements, and a drive power supply configured to apply voltage across the plurality of ultrasound generation elements of the ultrasound generation member.
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