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公开(公告)号：US20230287350A1
公开(公告)日：2023-09-14
申请号：US18005879
申请日：2021-08-16
Inventor： Shulamit Levenberg , Shaowei Guo , Lior Debbi
CPC classification number: C12N5/0658 , C12M35/04 , C12M25/14 , C12N2513/00
Abstract: The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles (EVs) from muscle cells utilizing various dynamic mechanical loading profiles thereon, cultured on three-dimensional (3D) scaffolds. The scaffolds may comprise a plurality of layers, wherein each layer comprises a plurality of elastic microfibers, and wherein the microfibers are aligned in parallel to a longitudinal axis and to each other. The elastic 3D scaffold may be configured to undergo dynamic mechanical loading profiles and support an expansion of a population of muscle cells cultured thereon into a 3D multi-layer structure of muscle cells, wherein said 3D multi-layer structure is configured to produce and/or secret extracellular vesicles into a medium.
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公开(公告)号：US20230240088A1
公开(公告)日：2023-07-27
申请号：US17819061
申请日：2022-08-11
Inventor： Tanmoy SARKAR , Gitti L. FREY
CPC classification number: H10K10/466 , H10K19/10
Abstract: A transistor structure is presented comprising: an organic semiconductor channel region, and source and drain electrodes in electrical contact with said organic semiconductor channel region, wherein at least one of said source and drain electrodes is formed by spaced apart regions of a first metallic material separated by regions of a second metallic material such that regions of the first and second metallic materials are in contact with the organic semiconductor channel region, said first metallic material being selected as having work function substantially similar to HOMO energy level of said organic semiconductor channel region and said second metallic material being selected as having work function substantially similar to LUMO energy level of said organic semiconductor channel region, thereby enabling selective injections of electrons or holes into said channel region.
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公开(公告)号：US20230223735A1
公开(公告)日：2023-07-13
申请号：US17997064
申请日：2021-04-27
Applicant: Technion Research and Development Foundation Ltd. , Julius-Maximilians-Universität Würzburg
Inventor： Mordechai SEGEV , Sven HOFLING , Sebastian KLEMBT , Alexander DIKOPOLTSEV , Tristan HARDER , Eran LUSTIG , Yaakov LUMER
CPC classification number: H01S5/0014 , H01S5/423 , H01S2301/20
Abstract: A laser source is presented a plurality of unit cells of a selected number of partially physically coupled lasing units arranged within a plane and configured to form a topological structure, wherein each of the lasing units is configured to emit radiation component substantially perpendicular to said plane, said plurality of the unit cells comprising at least a first sub-array of the unit cells located in a first region interfacing with a second region of a different type than said first region, thereby defining an arrangement of optically coupled lasing units along an interface region between the first and second adjacent regions, forming at least one topological state along a topological path within said interface region.
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114.发明授权公开(公告)号：US11609217B2
公开(公告)日：2023-03-21
申请号：US16948170
申请日：2020-09-04
Inventor： Yael Nemirovsky , Amikam Nemirovsky , Shmuel Melman
Abstract: A method for sensing gas by a gas sensing device, the method may include generating, by a semiconductor temperature sensing element that is spaced apart from a gas reactive element and is thermally coupled to the gas reactive element, detection signals that are indicative of a temperature of the gas reactive element; wherein the gas reactive element and the semiconductor temperature sensing element are of microscopic scale; and processing, by a readout circuit of the gas sensing device, the detection signals to provide information about a gas that affected the temperature of the gas reactive element.
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公开(公告)号：US11547307B2
公开(公告)日：2023-01-10
申请号：US16887246
申请日：2020-05-29
Inventor： Amir Landesberg , Anna Faingersh-Klebanov
IPC: A61B5/0205 , A61B5/021 , A61B5/08 , A61B5/00
Abstract: A method for detecting or monitoring respiratory or cardiac health of a patient includes measuring any intravascular or intracardiac pressure (IVP) of a patient over a period of time, said IVP including a measured respiratory wave, defining respiratory effort of the patient as a peak-to-peak amplitude of said respiratory wave, and using the respiratory effort to detect or monitor respiratory and cardiac health of the patient by comparing the respiratory effort with a known value of respiratory effort or by monitoring changes in the respiratory effort of the patient over another period of time.
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Patent Agency Ranking
116.发明申请公开(公告)号：US20220390625A1
公开(公告)日：2022-12-08
申请号：US17767790
申请日：2020-09-30
Inventor： Ido KAMINER , Yaniv KURMAN , Raphael DAHAN , Orr BEER
Abstract: The present invention discloses a scintillator structure and to a method for producing an output optical signal at a specific wavelength range. The scintillator structure comprises a multilayer nanostructure formed by at least one pair of alternating first and second layered material being arranged along one or more principal axes. The multi-layer nanostructure defines predetermined geometrical parameters and the structure is made of at least two different material compositions. At least one of the first layered material, the second layered material, or the combination of both, define scintillation properties. The invention also discloses a detector system for detecting an input radiation comprising a scintillator structure being as defined above and being configured and operable to collect most of the emitted optical signal.
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公开(公告)号：US20220349067A1
公开(公告)日：2022-11-03
申请号：US17810975
申请日：2022-07-06
Inventor： Gideon GRADER , Gennady SHTER , Hen DOTAN , Avner ROTHSCHILD , Avigail LANDMAN
Abstract: Provided are electrochemical cells and methods for generating hydrogen gas and oxygen gas.
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公开(公告)号：US20220193678A1
公开(公告)日：2022-06-23
申请号：US17601435
申请日：2020-04-06
Inventor： Shulamit LEVENBERG , Hagit STAUBER , Jonathan AVESAR
IPC: B01L3/00
Abstract: A device comprising: plurality of Stationary Nanoliter Droplet Array (SNDA) components; each SNDA component comprising: at least one primary channel; at least one secondary channel; and a plurality of nano-wells that are each open to the primary channel and are each connected by one or more vents to the secondary channel; the vents are configured to enable passage of air solely from the nano-wells to the secondary channel, such that when a liquid is introduced into the primary channel it fills the nano-wells, and the originally accommodated air is evacuated via the vents and the secondary channel/s; an inlet port and a distribution channel configured to enable a simultaneous introduction of the liquid into all primary channels; and an outlet port and an evacuation channel configured to enable a simultaneous evacuation of the air out of all the secondary channels.
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公开(公告)号：US20210393558A1
公开(公告)日：2021-12-23
申请号：US16957491
申请日：2018-12-31
Inventor： Daphne Weihs , Amit Gefen
Abstract: The technology subject of the present application aims at providing a methodology for prevention of pressure ulcers.
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120.发明授权公开(公告)号：US11117131B2
公开(公告)日：2021-09-14
申请号：US16108654
申请日：2018-08-22
Applicant: International Business Machines Corporation , Technion Research and Development Foundation Ltd.
Inventor： Govind Kaigala , Federico Paratore , Onur Gökçe , Moran Bercovici , Xander Van Kooten
IPC: B01L3/00 , G01N27/447 , C07K1/28
Abstract: Embodiments of the invention are directed to a method of separating and encapsulating an analyte on a microfluidic device in order to extract the analyte. A microfluidic device is provided having a main microchannel and a set of one or more auxiliary microchannels, each branching to the main microchannel at respective junctions therewith. A mixture is introduced as a single phase in the main microchannel in order to electrokinetically separate an analyte from the introduced mixture, and in order to confine the separated analyte in a microchannel portion of the main microchannel. The microchannel portion adjoins one of the junctions. One or more encapsulating volumes of an encapsulating phase are injected in the main microchannel via one or more of the auxiliary microchannels. The encapsulating phase is immiscible with said single phase. The encapsulated analyte is extracted from the main microchannel via one or more of the auxiliary microchannels.
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