公开(公告)号：US20200033351A1

公开(公告)日：2020-01-30

申请号：US16588208

申请日：2019-09-30

Applicant: Tel Hashomer Medical Research Infrastructure and Service Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Keren LEVANON ,  Tamar Geiger ,  Keren Bahar-Shany ,  Georgina D. Barnabas ,  Limor Helpman ,  Jacob Korach ,  Tamar Perri

IPC: G01N33/574 ,  G01N33/563 ,  G01N33/543

Abstract: The invention relates to novel biomarker signature, diagnostic methods, kits and compositions for early diagnosis of ovarian cancer, based on microvesicles prepared from body fluid sample, specifically, uterine lavage fluid (UtLF) sample.

公开(公告)号：US20180340146A1

公开(公告)日：2018-11-29

申请号：US15961907

申请日：2018-04-25

Applicant: ORGENESIS LTD. ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Sarah FERBER

IPC: C12N5/071 ,  G01N33/50

Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.

公开(公告)号：US20180264002A1

公开(公告)日：2018-09-20

申请号：US15996544

申请日：2018-06-04

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat Achiron ,  Roi Mashiach ,  Michael Gurevich

IPC: A61K31/551

CPC classification number: A61K31/551 ,  C07D513/14 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A50/414

Abstract: Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.

公开(公告)号：US20180249904A1

公开(公告)日：2018-09-06

申请号：US15971292

申请日：2018-05-04

Applicant: Tel Hashomer Medical Research Infrastructure and Services Ltd.

Inventor： Ygal Rotenstreich ,  Mordecai Rosner

IPC: A61B3/024 ,  A61B3/00 ,  A61B3/11 ,  A61B3/06 ,  A61B3/14

CPC classification number: A61B3/024 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/0091 ,  A61B3/066 ,  A61B3/112 ,  A61B3/14

Abstract: A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.

公开(公告)号：US10058710B2

公开(公告)日：2018-08-28

申请号：US14888756

申请日：2014-05-04

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Ifat Sher-Rosenthal ,  Ygal Rotenstreich

IPC: A61N2/00 ,  A61F9/00 ,  A61N2/02

CPC classification number: A61N2/006 ,  A61F9/00 ,  A61N2/004 ,  A61N2/02

Abstract: The present invention provides a device and a method for non-invasively enhancing the integrity of the cornea by applying a magnetic field, thereby treating eye disorders.

公开(公告)号：US20180228456A1

公开(公告)日：2018-08-16

申请号：US15750514

申请日：2016-08-04

Applicant: Tel HaShomer Medical Research, Infrastructure and Services Ltd.

Inventor： Miriam SKLAIR-LEVY ,  Arnaldo MAYER ,  Shmuel Yitzhak PFEFFER

IPC: A61B6/00 ,  A61B6/04 ,  G06T7/00 ,  G06T7/44 ,  G06T7/11 ,  G06T7/13

CPC classification number: A61B6/502 ,  A61B6/0414 ,  A61B6/0435 ,  A61B6/12 ,  A61B6/481 ,  A61B6/5205 ,  G06K9/4642 ,  G06K9/48 ,  G06K9/50 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/13 ,  G06T7/44 ,  G06T2207/10116 ,  G06T2207/20081 ,  G06T2207/30068

Abstract: A method of diagnosing breast cancer, the method comprising: acquiring a contrast enhanced region of interest (CE-ROI) comprised in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; generating a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI; and using a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.

公开(公告)号：US10022382B2

公开(公告)日：2018-07-17

申请号：US15626198

申请日：2017-06-19

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat Achiron ,  Roi Mashiach ,  Michael Gurevich

IPC: A61K31/551 ,  C07D471/12 ,  C07D513/14

Abstract: Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.

公开(公告)号：US09986907B2

公开(公告)日：2018-06-05

申请号：US15482205

申请日：2017-04-07

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Ygal Rotenstreich ,  Mordecai Rosner

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B3/00 ,  A61B3/024 ,  A61B3/11 ,  A61B3/06

CPC classification number: A61B3/024 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/0091 ,  A61B3/066 ,  A61B3/112 ,  A61B3/14

Abstract: The present invention relates to a system, device and a method for objective visual field testing and in particular, to such a system and method in which provides objective chromatic perimetry test or color vision test using a pupillometer.

公开(公告)号：US20180047158A1

公开(公告)日：2018-02-15

申请号：US15552278

申请日：2016-02-18

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Ofer GEVA ,  Hayit GRENSPAIN ,  Sivan LIEBERMAN ,  Eli KONEN

IPC: G06T7/00 ,  G06T7/11 ,  A61B6/00 ,  A61B5/08 ,  A61B5/00 ,  G06T7/44 ,  G06K9/46

CPC classification number: G06T7/0012 ,  A61B5/08 ,  A61B5/7267 ,  A61B6/50 ,  A61B6/5217 ,  A61B6/563 ,  G06K9/46 ,  G06K2009/4666 ,  G06K2209/051 ,  G06T7/11 ,  G06T7/12 ,  G06T7/44 ,  G06T2207/10116 ,  G06T2207/20124 ,  G06T2207/30061

Abstract: A method for estimating a presence of a pneumothorax abnormality. The method comprises classifying at least one texture feature of each of a plurality of pixels of a chest radiograph (CXR) image to generate an output map, identifying at least one lung contour in said CXR image, identifying a plurality of multiple pixel segments along said at least one lung contour, combining values of pixels in each one of said plurality of multiple pixel segments from said output map to generate a global descriptor for said CXR image, and estimating a presence of said pneumothorax abnormality in said CXR image by applying a statistical classifier on said global descriptor.

公开(公告)号：US20180008569A1

公开(公告)日：2018-01-11

申请号：US15538569

申请日：2016-01-13

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Ariel Hourvitz ,  Yuval Yung ,  Svetlana Markman ,  Gil Yerushalmi

IPC: A61K31/26 ,  A61K31/39 ,  C07D251/26 ,  A61K45/00

CPC classification number: A61K31/26 ,  A61K31/39 ,  A61K45/00 ,  C07D251/26

Abstract: The present invention provides methods and compositions for inhibiting ovulation in a female subject, including a subject in need of contraceptives and a subject undergoing fertility treatments. The methods comprise administering to the female subject at least one prostaglandin transporter (PGT) inhibitor.