公开(公告)号：US10173056B2

公开(公告)日：2019-01-08

申请号：US14413898

申请日：2013-07-11

Applicant: Tel Hashomer Medical Research Infrastructure and Service Ltd.

Inventor： Gil Raviv ,  David Shashar ,  Yoram Shadmi ,  Itzchak Shvitlowsky ,  David Castel

IPC: A61N1/20 ,  A61N1/36 ,  A61B5/00 ,  A61B10/00 ,  A61D19/00 ,  A61N1/04

Abstract: The present invention is directed to methods for improving male fertility inter alia by increasing sperm count in a male subject. The methods of the invention comprise applying a positive electrical current below sensation level to at least one site of a scrotum of a subject in need thereof.

公开(公告)号：US20160251410A1

公开(公告)日：2016-09-01

申请号：US14914003

申请日：2014-09-03

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICE LTD.

Inventor： Boaz TIROSH ,  Maya DADIANI

IPC: C07K16/00

CPC classification number: C07K16/00 ,  C07K2317/14 ,  C12N15/1135 ,  C12N15/67 ,  C12N2310/14

Abstract: Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been contacted with an agent which downregulates an expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and contacting the cell with a polynucleotide encoding the recombinant polypeptide of interest. Also provided is a method comprising contacting a cell with an agent which downregulates expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and a polynucleotide encoding the recombinant polypeptide of interest. Also provided are isolated cells, cell cultures and articles of manufacture for recombinant expression of a recombinant polypeptide of interest.

Abstract translation: 提供表达目标重组多肽的方法。 因此，提供了一种方法，其包括提供与下调结节性硬化症（TSC）蛋白的表达或直接抑制其活性的药剂接触的细胞; 并使细胞与编码感兴趣的重组多肽的多核苷酸接触。 还提供了一种方法，其包括使细胞与下调结节性硬化症（TSC）蛋白质的表达的试剂接触或直接抑制其活性; 和编码目的重组多肽的多核苷酸。 还提供了用于重组表达感兴趣的重组多肽的分离的细胞，细胞培养物和制品。

公开(公告)号：US20150190632A1

公开(公告)日：2015-07-09

申请号：US14413898

申请日：2013-07-11

Applicant: Tel Hashomer Medical Research Infrastructure and Service Ltd.

Inventor： Gil Raviv ,  David Shashar ,  Yoram Shadmi ,  Itzchak Shvitlowsky ,  David Castel

IPC: A61N1/20 ,  A61D19/00 ,  A61B5/00 ,  A61N1/04 ,  A61B10/00

CPC classification number: A61N1/205 ,  A61B5/4387 ,  A61B5/4836 ,  A61B10/0058 ,  A61B2503/40 ,  A61D19/00 ,  A61N1/0408 ,  A61N1/0492 ,  A61N1/36007 ,  F04C2270/041

Abstract: The present invention is directed to methods for improving male fertility inter alia by increasing sperm count in a male subject. The methods of the invention comprise applying a positive electrical current below sensation level to at least one site of a scrotum of a subject in need thereof.

Abstract translation: 本发明涉及通过增加男性受试者的精子计数来改善男性生育力的方法。 本发明的方法包括将低于感觉水平的正电流施加到有需要的受试者的阴囊的至少一个部位。

公开(公告)号：US20200033351A1

公开(公告)日：2020-01-30

申请号：US16588208

申请日：2019-09-30

Applicant: Tel Hashomer Medical Research Infrastructure and Service Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Keren LEVANON ,  Tamar Geiger ,  Keren Bahar-Shany ,  Georgina D. Barnabas ,  Limor Helpman ,  Jacob Korach ,  Tamar Perri

IPC: G01N33/574 ,  G01N33/563 ,  G01N33/543

Abstract: The invention relates to novel biomarker signature, diagnostic methods, kits and compositions for early diagnosis of ovarian cancer, based on microvesicles prepared from body fluid sample, specifically, uterine lavage fluid (UtLF) sample.

公开(公告)号：US20150119698A1

公开(公告)日：2015-04-30

申请号：US14584460

申请日：2014-12-29

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd. ,  Tel Hashomer Medical Research, Infrastructure And Service Ltd. ,  Drexel University

Inventor： Sara Eyal ,  Shlomo Magdassi ,  Emma Portnoy ,  Jacob Zauberman ,  Boris Polyak ,  Jacob Golenser ,  Yael Mardor ,  Dana Ekstein

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/055

CPC classification number: A61K49/0093 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4058 ,  A61K49/0017 ,  A61K49/0034

Abstract: Pharmaceutical composition including nanoparticles configured for enhanced phagocytosis by phagocytic cells and labeled with a near-infrared (NIR) fluorescent probe bound to the outer surface thereof, and uses thereof in the detection of activated immune cells in the central nervous system (CNS) of a subject.

Abstract translation: 药物组合物包括配置用于吞噬细胞增强的吞噬作用并用与其外表面结合的近红外（NIR）荧光探针）标记的纳米颗粒，以及其用于检测中枢神经系统（CNS）中活化的免疫细胞的用途 学科。