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公开(公告)号:US10717095B2
公开(公告)日:2020-07-21
申请号:US16073452
申请日:2017-02-02
Applicant: BAE SYSTEMS PLC , THE UNIVERSITY OF SHEFFIELD
Inventor: Martin Knott , Ryan Wesley Diver
Abstract: An end effector for a robot having a threaded shaft; a motor coupled to the shaft and configured to rotate the shaft about its axis; a nut threaded onto the shaft; a feature for preventing the nut from rotating about the axis of the shaft; and an elongate member fixed at one end to the nut and extending from the nut in a direction parallel to the axis of the shaft. The end effector may further include a container for containing a fluid having an elongate body portion having an opening at one end; and a reciprocable plunger extending into an opposite end of the body portion. A second end of the elongate member may be coupled to the plunger.
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公开(公告)号:US20200164033A1
公开(公告)日:2020-05-28
申请号:US16608611
申请日:2018-04-27
Applicant: University of Sheffield
Inventor: Ian Wilkinson , Richard Ross
IPC: A61K38/17 , A61K31/593 , C12N15/62 , C07K14/72 , A61K38/29 , A61K33/10 , C07K14/635
Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.
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公开(公告)号:US10596210B2
公开(公告)日:2020-03-24
申请号:US15557783
申请日:2016-03-11
Applicant: VIRTTU BIOLOGICS LIMITED , THE UNIVERSITY OF SHEFFIELD
Inventor: Joe Conner , Munitta Muthana , Claire Elizabeth Lewis
IPC: A01N63/00 , A61K35/763 , A61K41/00 , C12N5/0786 , A61K35/15 , A61K9/19 , A61M37/00 , A61K9/00 , A61K47/69 , A61K33/26 , A61K9/50 , C12N7/00
Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
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公开(公告)号:US10520446B2
公开(公告)日:2019-12-31
申请号:US15325070
申请日:2015-07-03
Applicant: Smith & Nephew PLC , University of Sheffield
Inventor: John Kenneth Hicks , Stephen Rimmer , Dorothy McCulloch , Richard Hoskins
IPC: C12Q1/18 , G01N21/77 , A61L15/26 , A61L15/42 , C08L75/02 , C08L33/26 , G01N21/78 , A61L15/58 , C08F220/56 , G01N33/569
Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilized therein, or modified by the immobilization therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilization, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereof.
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公开(公告)号:US20190194660A1
公开(公告)日:2019-06-27
申请号:US16304487
申请日:2017-05-30
Applicant: University of Sheffield
Inventor: Guillaume Hautbergue , Mimoun Azzouz , Alexander Whitworth , Pamela Shaw
IPC: C12N15/113 , C12N9/12
CPC classification number: C12N15/113 , A61K38/00 , A61P35/00 , C12N9/1205 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2740/16043 , C12Y207/11001
Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.
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公开(公告)号:US10280197B2
公开(公告)日:2019-05-07
申请号:US15295979
申请日:2016-10-17
Applicant: The Regents of the University of California , The Texas A & M University System , The University of Queensland , University of Sheffield
Inventor: Dimitrios Monikis , Christodoulos Floudas , Trent Woodruff , Matthew A. Cooper , Daniel E. Croker , Peter N. Monk
Abstract: A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.
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公开(公告)号:US10128709B2
公开(公告)日:2018-11-13
申请号:US14648602
申请日:2013-11-29
Applicant: The University of Sheffield
Inventor: Jiabin Wang
Abstract: An electric machine comprising: a) a first means for providing a first magneto motive force comprising a first set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic in said first set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant undesirable harmonic; and b) a second means for providing a second magneto motive force comprising a second set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said second set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant undesirable harmonic; wherein the net effect of said first and second means provides a resultant magneto motive force comprising a resultant set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said resultant set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said resultant set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said resultant set of magneto motive force space harmonics comprises a dominant undesirable harmonic, wherein the amplitude of the dominant undesirable harmonic of the resultant set of magneto motive force space harmonics is at least reduced relative to the amplitudes of the dominant undesirable harmonics of the first and second sets of harmonics.
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公开(公告)号:US20170271846A1
公开(公告)日:2017-09-21
申请号:US15505836
申请日:2015-08-21
Applicant: The University of Sheffield
Inventor: Richard James Edward Taylor , David T. D. Childs , Richard Hogg
CPC classification number: H01S5/105 , H01S5/02453 , H01S5/026 , H01S5/042 , H01S5/0608 , H01S5/0612 , H01S5/0614 , H01S5/1021 , H01S5/1028 , H01S5/1032 , H01S5/18 , H01S5/18319 , H01S5/1833 , H01S5/187 , H01S5/2018 , H01S5/2031 , H01S5/34353 , H01S5/3436 , H01S5/34366 , H01S5/4012 , H01S5/4075 , H01S5/42 , H01S5/423
Abstract: A laser structure comprising a first photonic crystal surface emitting laser (PCSEL), a second PCSEL, and a coupling region that extends between the first PCSEL and the second PCSEL along a longitudinal axis and that is electrically controllable so as to be capable of coherently coupling the first PCSEL to the second PCSEL. Each PCSEL include an active layer, a photonic crystal, and a two-dimensional periodic array distributed in an array plane parallel to the longitudinal axis within the photonic crystal where the two-dimensional periodic array is formed of regions having a refractive index that is different to the surrounding photonic crystal.
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公开(公告)号:US20130185828A1
公开(公告)日:2013-07-18
申请号:US13656172
申请日:2012-10-19
Applicant: The Regents of the University of California , The University of Nottingham , The University of Sheffield
Inventor: Julia Bailey-Serres , Michael Holdsworth , Julie Gray
IPC: C12N15/82
CPC classification number: C12N15/8271 , C07K14/415 , C12N15/8251 , C12N15/8261 , C12N15/8267 , C12N15/8273
Abstract: Provided are methods and compositions for improving the growth characteristics of plants.
Abstract translation: 提供了用于改善植物生长特性的方法和组合物。
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