公开(公告)号：US5876465A

公开(公告)日：1999-03-02

申请号：US916407

申请日：1997-08-22

Applicant: Eric Terranova ,  Aziz Fadli ,  Alain Lagrange

Inventor： Eric Terranova ,  Aziz Fadli ,  Alain Lagrange

IPC: D06B9/02 ,  A61K8/00 ,  A61K8/20 ,  A61K8/22 ,  A61K8/23 ,  A61K8/34 ,  A61K8/40 ,  A61K8/41 ,  A61K8/49 ,  A61Q5/10 ,  C07D209/40 ,  A61K7/13

CPC classification number: C07D209/40 ,  A61K8/492 ,  A61Q5/10 ,  A61K2800/88

Abstract: A composition for dyeing keratin fibres, and in particular human keratin fibres such as the hair, characterized in that it comprises, in a medium which is suitable for dyeing:at least one coupler selected from 2-iminoindoline derivatives of formula (I) and acid addition salts thereof: ##STR1## in which: R.sub.1 represents hydrogen, alkyl, hydroxyalkyl, alkoxycarbonyl or acyl;R.sub.2 represents hydrogen, alkyl, phenyl or arylsulphonyl;R.sub.3 represents hydrogen or alkyl which may be substituted with one or more hydroxyl, alkoxy, amino, alkylamino, dialkylamino, cyano or aryl groups;R.sub.4 and R.sub.5, which may be identical or different, denote hydrogen, hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino, aralkyl, halogen or a nitro group; andat least one oxidation base.

Abstract translation: 用于染色角蛋白纤维，特别是人角蛋白纤维如毛发的组合物，其特征在于，它在适于染色的介质中包含：至少一种选自式（I）的2-亚氨基二氢吲哚衍生物和酸 其加成盐：其中：R1表示氢，烷基，羟基烷基，烷氧基羰基或酰基; R 2表示氢，烷基，苯基或芳基磺酰基; R 3表示氢或可被一个或多个羟基，烷氧基，氨基，烷基氨基，二烷基氨基，氰基或芳基取代的烷基; R 4和R 5可以相同或不同，表示氢，羟基，烷基，烷氧基，氨基，烷基氨基，二烷基氨基，芳烷基，卤素或硝基; 和至少一个氧化基。

公开(公告)号：US5735910A

公开(公告)日：1998-04-07

申请号：US775566

申请日：1996-12-31

Applicant: Alain Lagrange ,  Alain Genet

Inventor： Alain Lagrange ,  Alain Genet

IPC: C07C315/02 ,  A61K8/41 ,  A61Q5/06 ,  C07C317/36 ,  C07C323/35 ,  C07C323/36 ,  C07C323/37 ,  C07C323/41 ,  C07C323/43 ,  C09B51/00 ,  A61K7/13

CPC classification number: A61Q5/065 ,  A61K8/418 ,  C07C317/36 ,  C07C323/36 ,  C07C323/37 ,  C07C323/41 ,  C07C323/43

Abstract: Novel nitrobenzene compounds of the nitroparaphenylenediamine type substituted by sulphur in the 5-position are disclosed. These compounds are intended especially for the dyeing of keratin fibres and in particular human hair. A process for their preparation, dyeing compositions in which these compounds are present and a dyeing process in which these compositions are used are also disclosed.

Abstract translation: 公开了由5位被硫取代的硝基对苯二胺类型的新型硝基苯化合物。 这些化合物特别用于染色角蛋白纤维，特别是人类头发。 还公开了其制备方法，其中存在这些化合物的染色组合物和其中使用这些组合物的染色方法。

公开(公告)号：US5717108A

公开(公告)日：1998-02-10

申请号：US759648

申请日：1996-12-05

Applicant: Alain Lagrange ,  Michel Philippe ,  Remy Tuloup

Inventor： Alain Lagrange ,  Michel Philippe ,  Remy Tuloup

IPC: C07D209/08 ,  C12P17/10 ,  C07D209/12

CPC classification number: C07D209/08 ,  C12P17/10

Abstract: The present invention relates to a novel process for the preparation of a monohydroxyindole or dihydroxyindole compound by a single step of placing in contact, in a solvent medium, at least one hydrolase with at least one indole compound bearing one or two radicals connected by an ester function to the benzene ring.

Abstract translation: 本发明涉及一种制备单羟基吲哚或二羟基吲哚化合物的新方法，其单一步骤是在溶剂介质中与至少一种含有一个或两个由酯连接的基团的至少一个吲哚化合物接触至少一种水解酶 功能于苯环。

公开(公告)号：US5714134A

公开(公告)日：1998-02-03

申请号：US758300

申请日：1996-12-03

Applicant: Herve Richard ,  Madeleine Leduc ,  Alain Lagrange

Inventor： Herve Richard ,  Madeleine Leduc ,  Alain Lagrange

IPC: A61K8/60 ,  A61K8/00 ,  A61K8/06 ,  A61K8/58 ,  A61K8/72 ,  A61K8/89 ,  A61K8/891 ,  A61K8/896 ,  A61K8/898 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07F7/08 ,  C07F7/18 ,  C07F7/21 ,  C08G77/14 ,  C08G77/22 ,  C08G77/388 ,  C08L83/06 ,  A61K7/42

CPC classification number: A61K8/898 ,  A61K8/585 ,  A61Q17/04 ,  C07F7/0812 ,  C07F7/0854 ,  C07F7/21 ,  C08G77/388 ,  A61K2800/57

Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise a photoprotecting effective amount of a novel benzotriazole-substituted polyorganosiloxane/polyorganosilane having one of the formulae (1) to (3): ##STR1## wherein A is a monovalent benzotriazole radical which comprises an acrylate or acrylamide functional group, which is bonded directly to a silicon atom, and which has the formula (4): ##STR2##

Abstract translation: 特别适用于对人类皮肤和/或头发进行增强光保护以防UV-A和UV-B照射特别是太阳辐射的破坏性影响的局部适用的防晒/美容组合物包含光保护有效量的新型苯并三唑取代的聚有机硅氧烷/聚有机硅烷 具有式（1）至（3）中的一个：其中A是包含丙烯酸酯或丙烯酰胺官能团的一价苯并三唑基团，其中A 1（R'）3（3） 其直接与硅原子键合，并且具有式（4）：（4）

公开(公告)号：US5667792A

公开(公告)日：1997-09-16

申请号：US684705

申请日：1996-07-19

Applicant: Alex Junino ,  Alain Lagrange ,  Quang Lan N'Guyen ,  Marie-Alix Bourboulon

Inventor： Alex Junino ,  Alain Lagrange ,  Quang Lan N'Guyen ,  Marie-Alix Bourboulon

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/14 ,  A61K8/33 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07C69/732 ,  C07C69/734 ,  C07C69/86 ,  C07C69/92 ,  C07C235/34 ,  A61K7/42

CPC classification number: C07C69/732 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61Q17/04 ,  A61Q19/02 ,  Y10S514/844 ,  Y10S514/846 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/943 ,  Y10S514/944 ,  Y10S977/926

Abstract: A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub. -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

Abstract translation: 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。

公开(公告)号：US5583234A

公开(公告)日：1996-12-10

申请号：US119072

申请日：1993-12-29

Applicant: Alain Lagrange ,  Herv e Andrean ,  Alex Junino

Inventor： Alain Lagrange ,  Herv e Andrean ,  Alex Junino

IPC: A61K8/00 ,  A61K8/04 ,  A61K8/49 ,  A61K8/89 ,  A61K8/891 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q3/00 ,  A61Q3/02 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q17/04 ,  C07D209/04 ,  C07D209/08 ,  C07D209/10 ,  C08G61/12 ,  C08G73/06 ,  C08K5/3417 ,  C08L101/00 ,  C09B69/10 ,  A61K7/13

CPC classification number: A61Q17/04 ,  A61K8/492 ,  A61Q1/02 ,  A61Q5/10 ,  C08G61/124 ,  C09B69/104

Abstract: An indoline product obtained by oxidizing at least one compound of formula (I), ##STR1## wherein R.sub.1 and R.sub.3 independently represent a hydrogen atom or a C.sub.1-4 alkyl grouping; R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkyl grouping, a carboxyl grouping or C.sub.1-4 alkoxycarbonyl; R.sub.4 is a hydrogen atom, a C.sub.1-4 alkyl grouping, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-10 amino or alkylamino, or halogen; R.sub.5 is a hydrogen atom, a hydroxyl grouping, C.sub.1-4 alkoxy or amino; with the proviso that at least one of the radicals R.sub.4 or R.sub.5 is a hydroxyl, alkoxy or amino grouping, and that when R.sub.5 is an amino grouping, R.sub.4 is not an alkylamino radical; R.sub.4 and R.sub.5 may also form a C.sub.1-2 alkylenedioxy ring and are in positions 5 and 6; and corresponding salts thereof. Said product may be used in cosmetics as make-up for the hair, eyebrows, eyelashes, nails, etc., and/or skin.

Abstract translation: PCT No.PCT / FR93 / 00030 Sec。 371日期1993年12月29日第 102（e）日期1993年12月29日PCT 1993年1月13日PCT PCT。 第WO93 / 13744号公报 日期：1993年7月22日通过氧化至少一种式（I）化合物，其中R 1和R 3独立地表示氢原子或C 1-4烷基; R2表示氢原子，C1-4烷基，羧基或C1-4烷氧基羰基; R4是氢原子，C1-4烷基，羟基，C1-4烷氧基，C1-10氨基或烷基氨基或卤素; R5是氢原子，羟基，C1-4烷氧基或氨基; 条件是基团R 4或R 5中的至少一个是羟基，烷氧基或氨基，并且当R 5是氨基时，R 4不是烷基氨基; R4和R5也可以形成C1-2亚烷基二氧基环，位于5和6位; 及其相应的盐。 所述产品可用于化妆品中作为头发，眉毛，睫毛，指甲等的化妆和/或皮肤。

公开(公告)号：US5569451A

公开(公告)日：1996-10-29

申请号：US555334

申请日：1995-11-08

Applicant: Herv e Richard ,  Madeleine Leduc ,  Alain Lagrange

Inventor： Herv e Richard ,  Madeleine Leduc ,  Alain Lagrange

IPC: A61K8/60 ,  A61K8/00 ,  A61K8/06 ,  A61K8/49 ,  A61K8/58 ,  A61K8/92 ,  A61K31/695 ,  A61P17/00 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07F7/08 ,  C07F7/10 ,  A61K7/42

CPC classification number: A61K8/585 ,  A61Q17/04 ,  C07F7/0812 ,  Y10S514/937 ,  Y10S514/938

Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise a photoprotecting effective amount of a novel triorganosilylated benzotriazole compound having the structural formula (1): ##STR1##

Abstract translation: 特别适用于对人体皮肤和/或头发进行增强光保护以抵抗UV-A和UV-B辐照（特别是太阳辐射）的破坏性影响的局部适用的防晒/化妆品组合物包含光保护有效量的新型三有机甲硅烷基化苯并三唑化合物，其具有结构 公式（1）：（1）

公开(公告)号：US5516942A

公开(公告)日：1996-05-14

申请号：US351242

申请日：1994-12-07

Applicant: Alain Lagrange ,  Alex Junino ,  Alain Genet ,  Jean Cotteret

Inventor： Alain Lagrange ,  Alex Junino ,  Alain Genet ,  Jean Cotteret

IPC: A61K8/00 ,  A61K8/31 ,  A61K8/34 ,  A61K8/35 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61Q5/06 ,  A61Q5/10 ,  C07C215/16 ,  C09B51/00 ,  C09B53/00 ,  D06P3/04 ,  D06P3/08 ,  A61K7/13

CPC classification number: A61K8/418 ,  A61Q5/065 ,  C07C215/16

Abstract: A N1,N4-dihydroxyethylated 2-nitro-p-phenylenediamine of formula (I), wherein R is C3-4 aklyl, and cosmetically acceptable salts thereof, for use in direct dyeing to give blue through purple shades which are wash-fast, light-fast, weatherproof and sweat resistant, and optionally combined with yellow and optionally read or orange-coloured dyes to give natural hues.

Abstract translation: PCT No.PCT / FR93 / 00571 Sec。 371日期1994年12月7日第 102（e）日期1994年12月7日PCT提交1993年6月15日PCT公布。 第WO94 / 00415号公报 日本1994年1月6日。一种式（I）的N1，N4-二羟基乙基化2-硝基 - 对苯二胺，其中R为C3-4亚烷基，及其美容上可接受的盐，用于直接染色以使紫色经紫色 洗涤快速，耐光，耐候和耐汗的色调，并且可选地与黄色和任选的读取或橙色染料组合以提供天然色调。

公开(公告)号：US5449518A

公开(公告)日：1995-09-12

申请号：US913950

申请日：1992-07-17

Applicant: Alex Junino ,  Alain Lagrange ,  Quang L. N'Guyen ,  Marie-Alix Bourboulon

Inventor： Alex Junino ,  Alain Lagrange ,  Quang L. N'Guyen ,  Marie-Alix Bourboulon

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/14 ,  A61K8/33 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07C69/732 ,  C07C69/734 ,  C07C69/86 ,  C07C69/92 ,  C07C235/34 ,  A61K7/42

CPC classification number: C07C69/732 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61Q17/04 ,  A61Q19/02 ,  Y10S514/844 ,  Y10S514/846 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/943 ,  Y10S514/944 ,  Y10S977/926

Abstract: A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, or ##STR2## R.sub.5 is a hydrogen atom, a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

Abstract translation: 具有脱色作用的化妆品或皮肤病学组合物包含2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R 1表示OR 5或

公开(公告)号：US5217709A

公开(公告)日：1993-06-08

申请号：US426427

申请日：1989-10-24

Applicant: Alain Lagrange ,  Serge Forestier ,  Gerard Lang ,  Bernadette Luppi

Inventor： Alain Lagrange ,  Serge Forestier ,  Gerard Lang ,  Bernadette Luppi

IPC: C07D307/32 ,  A61K8/00 ,  A61K8/34 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q3/02 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q17/04 ,  C07D307/58 ,  C07D307/94

CPC classification number: C07D307/58 ,  A61K8/4973 ,  A61Q17/04 ,  Y10S424/05 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/847 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944

Abstract: Cosmetic composition containing, by way of a compound screening cut UV of wavelengths 280-380 nm, a 5-benzylidene-3-oxacyclopentanone of formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 denote C.sub.1 -C.sub.8 alkyl, aralkyl or aryl, or alternatively R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 form, with the carbon to which they are attached, a saturated 5- or 6-membered ring, andR.sub.5, R.sub.6 and R.sub.7 denote H, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.1 -C.sub.12 alkoxy, C.sub.2 -C.sub.8 alkenyloxy, C.sub.2 -C.sub.12 acyloxy, benzyloxy or --COOR.sub.10 where R.sub.10 is a C.sub.1 --C.sub.8 alkyl, hydrogen, an alkali metal or alkaline earth metal or a radical derived from an amine, it also being possible for one of the substituents R.sub.5, R.sub.6 and R.sub.7 to denote a radical ##STR2## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the above meanings. This composition can be a protective composition for the human epidermis or the hair or an antisun composition.New compounds of formula (I) in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7, have the same meanings, R.sub.6 being other than hydrogen, methyl and methoxy.

Abstract translation: 含有通过化合物筛选方法切割波长为280-380nm的UV的式（I）的5-亚苄基-3-氧杂环戊酮的化妆品组合物：其中R 1，R 2，R 3和R 4表示C1- C 8烷基，芳烷基或芳基，或者R 1和R 2和/或R 3和R 4与它们所连接的碳形成饱和的5-或6-元环，并且R 5，R 6和R 7表示H， C8烷基，C2-C8烯基，C1-C12烷氧基，C2-C8链烯氧基，C2-C12酰氧基，苄氧基或-COOR10，其中R10是C1-C8烷基，氢，碱金属或碱土金属或衍生自 取代基R5，R6和R7之一也可以表示基团，其中R1，R2，R3和R4具有上述含义。 该组合物可以是人类表皮或毛发或防腐组合物的保护性组合物。 式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7具有相同的含义，R 6不同于氢，甲基和甲氧基。