公开(公告)号：US20130037026A1

公开(公告)日：2013-02-14

申请号：US13642420

申请日：2011-04-11

Applicant: Andrew Miller

Inventor： Andrew Miller

IPC: A61M16/00

Abstract: A respiratory device for delivering gas to a patient comprises a gases passageway having proximal and distal ends, and a supplementary gas inlet in a side wall of the gases passageway. The supplementary gas inlet is adapted to direct gas along an interior surface of the gases passageway, such that the gas follows a generally helical path towards the distal end of the gases passageway.

Abstract translation: 用于向患者输送气体的呼吸装置包括具有近端和远端的气体通道和气体通道的侧壁中的补充气体入口。 补充气体入口适于沿着气体通道的内表面引导气体，使得气体沿着朝向气体通道的远端的大致螺旋的路径。

公开(公告)号：US20130016963A1

公开(公告)日：2013-01-17

申请号：US13550260

申请日：2012-07-16

Applicant: Andrew Miller

Inventor： Andrew Miller

IPC: G02B21/36

CPC classification number: G02B21/362

Abstract: A device used to fasten a myriad of imaging units, including a large variety of camera enabled cell phones to a variety of optical systems, such as microscopes, in a non-restrictive, non-specific manor.

Abstract translation: 一种用于将各种成像装置固定的装置，包括各种各样的相机启动的手机到非限制性非特定庄园的各种光学系统，如显微镜。

公开(公告)号：US20120318622A1

公开(公告)日：2012-12-20

申请号：US13490701

申请日：2012-06-07

Applicant: Andrew Miller ,  Robert McDougall ,  Stuart Millgate

Inventor： Andrew Miller ,  Robert McDougall ,  Stuart Millgate

IPC: B60T1/06 ,  F16D65/38 ,  B65F3/00

CPC classification number: F16D65/0081 ,  F16D55/32 ,  F16D65/0075 ,  F16D65/186 ,  F16D65/853 ,  F16D2055/0008 ,  F16D2055/002 ,  F16D2055/0033 ,  F16D2055/0062 ,  F16D2121/02 ,  F16D2121/04 ,  F16D2121/10 ,  F16D2125/06 ,  F16D2125/14

Abstract: A wet disc brake system is described which includes a housing assembly and brake callipers. The housing assembly is provided with openings for seating cylinders of respective brake callipers. The callipers are coupled to a structural component of a vehicle to which the system is fitted and in particular a flange of an axle housing. This enables reactive forces created during a braking operation to be transmitted via the callipers to the flange and axle housing rather than being carried by housing assembly. As the housing assembly does not bear any substantive load, it may be made of a relatively light weight construction or material.

Abstract translation: 描述了一种湿盘式制动系统，其包括壳体组件和制动钳。 壳体组件设置有用于相应制动卡钳的气缸的开口。 卡钳耦合到系统安装到的车辆的结构部件，特别是车轴壳体的凸缘。 这使得在制动操作期间产生的反作用力经由卡钳传递到凸缘和轴壳体而不是由壳体组件承载。 由于外壳组件不承担任何实质负载，所以可以由相对较轻的结构或材料制成。

公开(公告)号：US20120284312A1

公开(公告)日：2012-11-08

申请号：US13099750

申请日：2011-05-03

Applicant: Abhijit Gore ,  Abhishek Agarwal ,  Kunal Garg ,  Ramani Jagadeba ,  Ankit Malpani ,  Adithya Vishwanath ,  Kulothungan Rajasekaran ,  Manjeet Bothra ,  Andrew Miller ,  David Shutt ,  Edward Martinez

Inventor： Abhijit Gore ,  Abhishek Agarwal ,  Kunal Garg ,  Ramani Jagadeba ,  Ankit Malpani ,  Adithya Vishwanath ,  Kulothungan Rajasekaran ,  Manjeet Bothra ,  Andrew Miller ,  David Shutt ,  Edward Martinez

IPC: G06F17/30

CPC classification number: G06Q30/01 ,  G06Q10/101

Abstract: A data reporting framework that works across on-premise and hosted Customer Relationship Management (CRM) platforms enabling definition and execution of secure custom reports is provided. A fetch query language of a CRM platform is used along with reporting service tools and constructs to enable users to upload and execute custom fetch based reports with support for expressions, code, formatting, and drill through. Users are also enabled to build simple reports from within CRM and, if needed, enhance those reports using reporting service tools and re-upload in CRM. Furthermore, custom reports may be executed in a sandboxed environment to provide full security in a multi-tenant, hosted CRM system.

Abstract translation: 提供了跨内部和托管的客户关系管理（CRM）平台的数据报告框架，可以定义和执行安全的自定义报告。 使用CRM平台的提取查询语言以及报告服务工具和结构，以使用户能够上传和执行基于表达式，代码，格式化和钻取的自定义基于抓取的报表。 用户还可以从CRM内部构建简单的报表，如果需要，可以使用报表服务工具来增强这些报表，并在CRM中重新上传。 此外，自定义报告可以在沙箱环境中执行，以在多租户托管的CRM系统中提供完全的安全性。

公开(公告)号：US20120136000A1

公开(公告)日：2012-05-31

申请号：US12670989

申请日：2010-01-27

Applicant: Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

Inventor： Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

IPC: A61K31/496 ,  A61K31/497 ,  A61K31/437 ,  A61K31/506 ,  A61P37/00 ,  A61P29/00 ,  A61P35/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P1/00 ,  A61P37/06 ,  A61P35/02 ,  A61P19/04 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/506 ,  C07D239/24 ,  C07D241/10 ,  C07D519/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

公开(公告)号：US20120056995A1

公开(公告)日：2012-03-08

申请号：US13222195

申请日：2011-08-31

Applicant: Goksel Dedeoglu ,  Andrew Miller

Inventor： Goksel Dedeoglu ,  Andrew Miller

IPC: H04N13/02

CPC classification number: G01S11/12 ,  G06T7/215 ,  G06T7/254 ,  G06T2207/10028 ,  G06T2207/20036 ,  G06T2207/30196 ,  G06T2207/30232 ,  G06T2207/30261 ,  H04N2013/0081

Abstract: A method and apparatus for stereo-based proximity warning system for vehicle safety. The method comprising capturing a right and a left image utilizing the right and left of stereo cameras, performing stereo analysis and depth computation for comparing and determining the depth deviation between the current depth image with the depth model, updating the depth model when there is minimal or no deviation, otherwise, performing morphological operations for clean-up and connected components analysis, and determining if the object is too close to be safe utilizing the component analysis, and generating a warning when the object is too close.

Abstract translation: 一种用于车辆安全的基于立体声的接近警报系统的方法和装置。 该方法包括利用立体相机的左右拍摄右图像和左图像，执行立体声分析和深度计算，以比较和确定当前深度图像与深度模型之间的深度偏差，当最小深度图像更新时，更新深度模型 或没有偏差，否则进行清理和连接的组件分析的形态操作，以及使用组件分析确定对象是否太靠近而不能安全，并且当对象太近时产生警告。

公开(公告)号：US20110155522A1

公开(公告)日：2011-06-30

申请号：US13056698

申请日：2009-07-31

Applicant: Andrew Miller

Inventor： Andrew Miller

IPC: B60T8/72 ,  B60T7/12 ,  B60T8/34

CPC classification number: B60T7/12 ,  B60T2201/03

Abstract: An emergency brake system (10) comprises first and second fluid communication paths (20) and (22) which provide fluid communication between a brake (18) and a hydraulic fluid tank (24). A first valve is provided in the first path (20) to vary pressure in the brake line (26) to a pressure P1 enabling the brake to apply a braking torque of T1 and a second valve (30) is provided in the path (22) to vary brake line pressure to a pressure P2 enabling the brake (18) to apply a braking torque of T2 where T2>T1. The system (10) senses the speed of a machine to which the brake (18) is coupled. Depending on the sensed speed of the machine when the emergency brake (18) is applied the system (10) will open one or both of the paths to control the braking torque applied by the brake (18).

Abstract translation: 紧急制动系统（10）包括在制动器（18）和液压油箱（24​​）之间提供流体连通的第一和第二流体连通路径（20）和（22）。 第一阀设置在第一路径（20）中，以将制动管路（26）中的压力改变为压力P1，使得制动器施加T1的制动转矩，并且在路径（22）中设置第二阀门（30） ）将制动管路压力改变为使得制动器（18）能够施加T2的制动转矩T2（T2）> T1的压力P2。 系统（10）感测制动器（18）联接到的机器的速度。 根据当紧急制动器（18）被施加时感测到的机器的速度，系统（10）将打开一个或两个路径以控制由制动器（18）施加的制动转矩。

公开(公告)号：US20110144074A1

公开(公告)日：2011-06-16

申请号：US13012180

申请日：2011-01-24

Applicant: Michael Mortimore ,  Andrew Miller ,  John Studley ,  Jean-Damien Charrier

Inventor： Michael Mortimore ,  Andrew Miller ,  John Studley ,  Jean-Damien Charrier

IPC: A61K31/58 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/473 ,  A61K31/55 ,  A61K31/496 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/538 ,  A61K31/498 ,  A61K31/45 ,  A61K31/4015 ,  A61P29/00 ,  A61P31/00 ,  A61P19/02 ,  A61P3/10 ,  A61P37/06 ,  A61P35/00 ,  A61P25/28 ,  A01N1/02 ,  C12N5/071

CPC classification number: A61K31/55 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/407 ,  A61K31/435 ,  A61K31/45 ,  A61K31/498 ,  A61K31/5025 ,  A61K31/538 ,  A61K31/54 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389

Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and R4 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.

Abstract translation: 本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R1是氢，-CHN2，R，CH2OR，CH2SR或-CH2Y; R3和R4之间代表单键或双键; Y是电负离子团; R2是CO 2 H，CH 2 CO 2 H或其酯，酰胺或等体积体; R3是能够适应胱天蛋白酶的S2亚位点的基团; R4是氢或C1-6烷基或R3和R4一起形成环; 环A和环B各自为杂环，R和R 5如说明书所述。 这些化合物是有效的凋亡抑制剂和IL-1和bgr; 分泌。

公开(公告)号：US20110081364A1

公开(公告)日：2011-04-07

申请号：US12847136

申请日：2010-07-30

Applicant: Hayley Binch ,  Daniel Robinson ,  Damien Fraysse ,  Andrew Miller

Inventor： Hayley Binch ,  Daniel Robinson ,  Damien Fraysse ,  Andrew Miller

IPC: A61K31/4985 ,  A61K31/5377 ,  A61K39/00 ,  A61P9/00 ,  A61P25/28 ,  A61P37/00 ,  A61P29/00 ,  A61P31/12 ,  A61P19/08 ,  A61P35/00 ,  A61P35/02 ,  C12N9/99

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US07807659B2

公开(公告)日：2010-10-05

申请号：US11522375

申请日：2006-09-14

Applicant: Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

Inventor： Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

IPC: A61K31/675 ,  A01N57/00

CPC classification number: C07D401/06 ,  C07D211/60 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

Abstract: The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), interferon-γ-(“IFN-γ”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention. This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-γ production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-γ-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.

Abstract translation: 本发明涉及新型的式I化合物，其为半胱天冬酶和TNF-α抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制半胱天冬酶和TNF-α活性，因此可有利地用作抗半胱天冬酶，白细胞介素-1（“IL-1”），细胞凋亡 - 干扰素 - γ诱导因子（IGIF），干扰素-γ-（“IFN-γ”）或TNF-α介导的疾病，包括炎性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，感染性疾病和退行性疾病。 本发明还涉及制备本发明化合物的方法。 本发明还涉及用于抑制半胱天冬酶和TNF-α活性并减少IGIF产生和IFN-γ产生的方法以及用于治疗半胱天冬酶，白细胞介素-1，细胞凋亡和干扰素-γ以及TNF-α介导的疾病的方法 本发明的化合物和组合物。