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265 条记录 (耗时 0.035 秒)

    Coating system for high temperature stainless steel
    112.
    发明授权
    Coating system for high temperature stainless steel 有权
    高温不锈钢涂层系统

    公开(公告)号：US06585864B1

    公开(公告)日：2003-07-01

    申请号：US09589196

    申请日：2000-06-08

    申请人： Gary Anthony Fisher ,  Robert Prescott ,  Yan Chen ,  Hang Zheng ,  Chinnia Subramanian ,  Andrew George Wysiekierski

    发明人： Gary Anthony Fisher ,  Robert Prescott ,  Yan Chen ,  Hang Zheng ,  Chinnia Subramanian ,  Andrew George Wysiekierski

    IPC分类号： C23C1435

    CPC分类号： C23C28/3215 ,  C23C26/00 ,  C23C28/322 ,  C23C28/325 ,  C23C28/345

    摘要： A method for protecting high temperature stainless steel from coking and corrosion at elevated temperatures in corrosive environments, such as during ethylene production, by coating the stainless steel with an overlay coating of MCrAlX in which M is nickel, cobalt, iron or a mixture thereof and X is yttrium, hafnium, zirconium, lanthanum or combination thereof. The overlay coating and stainless steel substrate are heat-treated to metallurgically bond the overlay coating to the substrate and to form a multiphased microstructure. The overlay coating preferably is aluminized by depositing a layer of aluminum thereon and subjecting the resulting coating to oxidation to form an alumina surface layer. An intermediary aluminum-containing diffusion coating may be deposited directly onto the stainless steel substrate prior to deposition of the overlay coating to form a protective interlayer between the stainless steel substrate and overlay coating.

    摘要翻译： 一种在腐蚀性环境例如乙烯生产过程中，在高温下保护高温不锈钢的方法，用不锈钢涂覆MCrAlX，其中M是镍，钴，铁或其混合物， X是钇，铪，锆，镧或其组合。 将覆盖层和不锈钢衬底进行热处理，将覆盖层冶金结合到衬底上并形成多相微结构。 覆盖涂层优选通过在其上沉积铝层而进行镀铝，并对所得到的涂层进行氧化以形成氧化铝表面层。 中间含铝扩散涂层可以在沉积覆盖层之前直接沉积到不锈钢衬底上，以在不锈钢衬底和覆盖涂层之间形成保护性中间层。

    Methods for producing a single stranded polydeoxynucleotide having two different defined sequences and kits
    114.
    发明授权
    Methods for producing a single stranded polydeoxynucleotide having two different defined sequences and kits 失效
    制备具有两个不同定义序列的单链多脱氧核苷酸的方法和试剂盒

    公开(公告)号：US5683879A

    公开(公告)日：1997-11-04

    申请号：US475236

    申请日：1995-06-07

    申请人： Maureen Laney ,  Yan Chen ,  Edwin F. Ullman ,  Karen M. Hahnenberger

    发明人： Maureen Laney ,  Yan Chen ,  Edwin F. Ullman ,  Karen M. Hahnenberger

    IPC分类号： C12N15/09 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/50 ,  C07H21/02 ,  C12P19/34

    CPC分类号： C12Q1/6853 ,  C12Q1/6844 ,  C12Q1/686

    摘要： A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide and a polynucleotide Q. The template polynucleotide has three sequences T1, T2 and T3 wherein T1 is non-contiguous and 3' of T3 and wherein the 5' end of T3 is 5' of the 5' end of T2. The primer polynucleotide has a second defined sequence at its 3' end that is hybridizable with T1. The blocker polynucleotide has sequence B1 that is hybridizable with T3. Polynucleotide Q has sequences S1 and S2 wherein S1 is 3' of S2 and homologous with T2 and S2 is complementary to a first defined sequence that is to be introduced at the 3' end of the polynucleotide primer, when it is extended during the method of the invention. Polynucleotide Q is either attached to the 5' end of the blocker polynucleotide or present as a separate reagent. The primer is extended along the template polynucleotide and along at least a portion of sequence T2 and thereafter along the polynucleotide Q to give a single stranded polynucleotide having two or more defined sequences.

    摘要翻译： 公开了一种扩展引物以产生具有两个或多个限定序列的单链多脱氧核苷酸的方法。 提供了包含模板多核苷酸，阻断多聚核苷酸，引物多核苷酸和多核苷酸Q的组合。模板多核苷酸具有三个序列T1，T2和T3，其中T1不连续且T3的3'，其中5'末端 T3的T3的5'端是5'。 引物多核苷酸在其3'端具有与T1杂交的第二定义序列。 阻断剂多核苷酸具有可与T3杂交的序列B1。 多核苷酸Q具有序列S1和S2，其中S1是S2的3'，与T2同源，S2与在多核苷酸引物的3'端引入的第一定义序列互补，当其在 本发明。 多核苷酸Q连接于阻断多核苷酸的5'末端或作为单独的试剂存在。 引物沿着模板多核苷酸并沿着序列T2的至少一部分延伸，然后沿着多核苷酸Q延伸，得到具有两个或多个限定序列的单链多核苷酸。

    2,4-diamino-pyrimidine compounds and method for making and using the compounds
    115.
    发明授权
    2,4-diamino-pyrimidine compounds and method for making and using the compounds 有权

    公开(公告)号：US10710983B2

    公开(公告)日：2020-07-14

    申请号：US15633258

    申请日：2017-06-26

    申请人： Yan Chen ,  Rose Yen ,  Jiaxin Yu ,  Vanessa Taylor ,  Rajinder Singh

    发明人： Yan Chen ,  Rose Yen ,  Jiaxin Yu ,  Vanessa Taylor ,  Rajinder Singh

    IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D239/48 ,  C07D405/14

    摘要： Compounds within the scope of the present invention have a Formula 1 or a salt or prodrug thereof, where ring A is selected from cycloaliphatic; ring B is aryl; R1 is selected from (C1-C10)alkyl, (C3-C10)cycloalkyl, halo, aryl, and heteroaryl; and R2 and R3 are independently selected from hydrogen and (C1-C6)alkyl. Disclosed compounds may have an IRAK4 IC50 of from 0.003 μM to 3.7 μM; a TAK1 IC50 of from 0.008 μM to 132 μM; and/or an IRAK4/TAK1 selectivity of from 1 to 450. Particular compounds may have an IRAK4/TAK1 selectivity of from 100 to 500. Disclosed compositions may be formulated as pharmaceutical compositions. A method for using the compounds and/or compositions also are disclosed. The method may comprise administering to a subject an effective amount of a compound within the scope of the present invention, particularly to selectively inhibit IRAK 1 and/or IRAK4 over TAK1.

    Loop-shaped primer used in nucleic acid amplification and the use thereof
    118.
    发明授权
    Loop-shaped primer used in nucleic acid amplification and the use thereof 有权

    公开(公告)号：US09644233B2

    公开(公告)日：2017-05-09

    申请号：US13142874

    申请日：2009-03-26

    申请人： Li Ruan ,  Donghua He ,  Limou Zheng ,  Yan Chen

    发明人： Li Ruan ,  Donghua He ,  Limou Zheng ,  Yan Chen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/686 ,  C12Q2525/301

    摘要： Loop-shaped primer used in nucleic acid amplification is an oligonucleotide with 3-20 bases in both 3′ and 5′ ends which can be combined together to form a double-strand under appropriate conditions, resulting in the primer forming a stem-loop structure. The double-stranded structure is opened and the stem-loop structure dissolves when the primer recognizes and hybridizes with the target sequence. If the target sequence is not present the primer can form a stem-loop structure automatically by self-annealing. The primer can comprise a universal tag sequence or not. Together with universal tag sequence primer the primer comprising the universal tag sequence can be used for a second round of amplification. The primer has high specificity and does not form a primer dimmer. The primer is easy to design and is suitable for measuring gene expression and detecting features of nucleic acids such as SNPs and rare mutations.