公开(公告)号：US07579166B2

公开(公告)日：2009-08-25

申请号：US10480790

申请日：2002-06-14

Applicant: Yasunori Chiba ,  Yoshifumi Jigami ,  Hitoshi Sakuraba ,  Kazuo Kobayashi ,  Makoto Takeuchi ,  Yoriko Takeuchi, legal representative

Inventor： Yasunori Chiba ,  Yoshifumi Jigami ,  Hitoshi Sakuraba ,  Kazuo Kobayashi ,  Makoto Takeuchi

IPC: C12N15/00 ,  C12P21/00 ,  C12Q1/68 ,  C07K14/00

CPC classification number: C12P21/005 ,  A61K36/064 ,  A61K38/17 ,  C12N9/1051 ,  A61K2300/00

Abstract: A process for producing a lysosomal enzyme having a mannose-6-phosphate-containing acidic sugar chain, wherein the process comprising: culturing in a medium yeast cells obtained by introducing a lysosomal enzyme gene into a sugar chain biosynthetic enzyme gene mutant strain of yeast, collecting a lysosomal enzyme having a phosphate-containing sugar chain from the culture, and then treating the enzyme with α-mannosidase; and pharmaceutical compositions for treatment of human lysosomal enzyme deficiencies produced by the process. The genetic engineering technique using the yeast according to the present invention allows large-amount and high-purity production of a glycoprotein having a phosphate-containing acidic sugar chain which can serve as a labeling marker for transporting into lysosomes in cells of mammals such as human. The glycoprotein having a phosphate-containing acidic sugar chain according to the invention may be utilized as a drug effective in treatment of human lysosomal enzyme deficiencies, etc.

Abstract translation: 一种生产含有甘露糖-6-磷酸的酸性糖链的溶酶体酶的方法，其中所述方法包括：在通过将溶酶体酶基因导入酵母的糖链生物合成酶基因突变菌株获得的培养基中培养酵母， 从培养物中收集含有含磷酸盐糖链的溶酶体酶，然后用α-甘露糖苷酶处理酶; 以及用于治疗由该方法产生的人溶酶体酶缺陷的药物组合物。 使用根据本发明的酵母的基因工程技术允许大量和高纯度产生具有含磷酸盐的酸性糖链的糖蛋白，其可以用作在诸如人类的哺乳动物的细胞中输送到溶酶体的标记标记 。 具有根据本发明的含磷酸盐酸性糖链的糖蛋白可以用作治疗人溶酶体酶缺陷等的药物。

公开(公告)号：US07425181B2

公开(公告)日：2008-09-16

申请号：US11716577

申请日：2007-03-12

Applicant: Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

Inventor： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

IPC: F16D7/02 ,  F16D3/66 ,  F16D69/00

CPC classification number: F16F15/129

Abstract: A torque fluctuation absorbing device includes a first rotational member which transmits a torque from a driving power source, a damping mechanism connected with an input shaft of a transmission, the damping mechanism having a pair of frictional members of approximately annular-shaped fixed at both surfaces of a disc, and a limiter portion for frictionally engaging the pair of frictional members with the first rotational member in a substantially direct manner or in a substantially indirect manner via a pair of frictional plates. An actual length of at least one of the pair of frictional members ranges substantially between 1 percent and 6 percent of a major diameter of the at least one of the pair of frictional members.

Abstract translation: 扭矩波动吸收装置包括：传递来自驱动动力源的转矩的第一旋转构件，与变速器的输入轴连接的阻尼机构，所述阻尼机构具有在两面固定的大致环状的一对摩擦构件 以及限制器部分，用于通过一对摩擦板以基本上直接的方式或以基本上间接的方式摩擦地与所述第一旋转部件摩擦接合所述一对摩擦部件。 一对摩擦构件中的至少一个的实际长度基本上在一对摩擦构件中的至少一个的大直径的1％至6％之间。

公开(公告)号：US20080211660A1

公开(公告)日：2008-09-04

申请号：US11983511

申请日：2007-11-09

Applicant: Makoto Takeuchi

Inventor： Makoto Takeuchi

IPC: G08B29/06

CPC classification number: G05B19/0428 ,  G05B2219/21162

Abstract: A field device system having a transmission line, includes a diagnostic module that detects whether or not a failure of the transmission line is present.Also, the diagnostic module has at least one measuring portion for measuring electric characteristics of the transmission line, and the like.

Abstract translation: 具有传输线的现场设备系统包括检测传输线路故障是否存在的诊断模块。 此外，诊断模块具有至少一个用于测量传输线的电特性的测量部分等。

公开(公告)号：US20080163609A1

公开(公告)日：2008-07-10

申请号：US11883335

申请日：2005-11-10

Applicant: Hitoshi Satou ,  Takehito Imai ,  Tatsuo Mashiko ,  Takao Onodera ,  Makoto Takeuchi ,  Mamoru Komine ,  Nobuyuki Hiraki

Inventor： Hitoshi Satou ,  Takehito Imai ,  Tatsuo Mashiko ,  Takao Onodera ,  Makoto Takeuchi ,  Mamoru Komine ,  Nobuyuki Hiraki

IPC: F01N9/00

CPC classification number: B01D53/944 ,  F01N3/0231 ,  F01N9/002 ,  F01N13/0097 ,  F01N2900/102 ,  F01N2900/1606 ,  Y02T10/47

Abstract: An exhaust emission control system [1] comprising a continuous regenerating DPF [13] and a DPF controlling means [30C], wherein control is so performed as to accept the operation of a forced regenerating means [34C] at an operation request by a driver when it is judged a traveling distance [ΔMc] after starting collection detected by a traveling distance detecting means [33C] has reached a specified judging traveling distance [ΔM1] even when the DPF controlling means [30C] detects a collection amount [ΔPm] detected by a collection amount detecting means [32C] is smaller than a specified judging collection amount [ΔP1]. Accordingly, in a continuous regenerating DPF [13] capable of manual regenerating, the number of warning such as a blinking regeneration button prompting a manual regeneration is reduced to relieve a driver of trouble.

Abstract translation: 一种排气排放控制系统[1]，包括连续再生DPF [13]和DPF控制装置[30 C]，其中，控制被执行以在操作请求下接受强制再生装置[34C]的操作 即使当DPF控制装置[30C]检测到集合时，当判断由行驶距离检测装置[33 C]检测到的开始采集之后的行驶距离[ΔMc]已经达到指定的判断行驶距离[ΔM1]时的驾驶员 由收集量检测装置[32 C]检测的量[ΔPm]小于指定的判断收集量[ΔP1]。 因此，在能够手动再生的连续再生DPF [13]中，减少了提示手动再生的闪烁再生按钮等警告的数量，以减轻驾驶员的麻烦。

公开(公告)号：US07377853B2

公开(公告)日：2008-05-27

申请号：US10967264

申请日：2004-10-19

Applicant: Makoto Takeuchi ,  Masaru Ebata ,  Satoshi Nakagaito

Inventor： Makoto Takeuchi ,  Masaru Ebata ,  Satoshi Nakagaito

IPC: F16D7/02

CPC classification number: F16F15/1297

Abstract: A torque fluctuation absorbing device includes a damping mechanism connected with an input shaft of a transmission. The damping mechanism has an approximately annular-shaped frictional member, which is fixed to both surfaces of a disc disposed at outer peripheral portion. The torque fluctuation absorbing device further includes a flywheel for transmitting driving force from a driving power source, a first plate rotated with the flywheel and abutting on a first surface of the frictional member, a second plate abutting on a second surface of the frictional member, a coned disk spring for biasing the second plate against the frictional member, a supporting member rotated with the first plate and supporting the coned disk spring, and a plurality of fixation members for fixing the first plate with the supporting member. The first plate includes a reinforcement portion which reinforces rigidity of the first plate at an inner circumference portion located radially inwardly relative to the frictional member.

Abstract translation: 扭矩波动吸收装置包括与变速器的输入轴连接的阻尼机构。 阻尼机构具有近似环形的摩擦构件，其固定到设置在外周部分的盘的两个表面。 扭矩波动吸收装置还包括用于从驱动动力源传递驱动力的飞轮，与飞轮一起旋转并抵靠在摩擦构件的第一表面上的第一板，抵靠在摩擦构件的第二表面上的第二板， 用于将第二板偏置抵靠摩擦构件的锥形盘弹簧，与第一板一起旋转并支撑盘形弹簧的支撑构件，以及用于将第一板与支撑构件固定的多个固定构件。 第一板包括加强部分，该加强部分在相对于摩擦构件径向向内定位的内周部分处加强第一板的刚度。

公开(公告)号：US07344365B2

公开(公告)日：2008-03-18

申请号：US11602965

申请日：2006-11-22

Applicant: Makoto Takeuchi ,  Tetsuzo Ukai ,  Masaaki Tokuda

Inventor： Makoto Takeuchi ,  Tetsuzo Ukai ,  Masaaki Tokuda

IPC: F03C2/00 ,  F04C18/00 ,  F04C2/00

CPC classification number: F04C28/26 ,  F04C18/0215 ,  F04C18/0261 ,  F04C18/0276 ,  F04C18/088

Abstract: A scroll compressor includes a first scroll and a second scroll. The first scroll has a step portion that separates an elevated portion and a recessed portion of a surface of the first scroll. A spiral wall of the second scroll has a step that separates an elevated portion and a recessed portion of the wall. A first bypass hole is provided in the elevated portion of the surface of the first scroll. A second bypass hole is provided in the recessed portion of the surface of the first scroll. The second bypass hole is within 360 degrees toward a center of the spiral of the first scroll from an outer end of the spiral. The first bypass hole is within 360 degrees from the second bypass hole toward the center of the spiral.

Abstract translation: 涡旋压缩机包括第一涡旋件和第二涡旋件。 第一涡旋件具有分离第一涡旋件的表面的升高部分和凹部的台阶部分。 第二涡卷的螺旋壁具有分隔壁的升高部分和凹陷部分的台阶。 第一旁通孔设置在第一涡旋盘的表面的升高部分中。 第二旁通孔设置在第一涡旋盘的表面的凹部中。 第二旁通孔从螺旋的外端朝向第一涡旋盘的螺旋的中心360度内。 第一旁通孔与第二旁通孔朝向螺旋中心360度以内。

公开(公告)号：US20070292293A1

公开(公告)日：2007-12-20

申请号：US11700874

申请日：2007-02-01

Applicant: Katsuhiro Fujita ,  Tomohisa Moro ,  Takayuki Kuwahara ,  Kazuhide Watanabe ,  Tetsuzou Ukai ,  Norio Hioki ,  Hiroshi Yamazaki ,  Makoto Takeuchi ,  Takamitsu Himeno

Inventor： Katsuhiro Fujita ,  Tomohisa Moro ,  Takayuki Kuwahara ,  Kazuhide Watanabe ,  Tetsuzou Ukai ,  Norio Hioki ,  Hiroshi Yamazaki ,  Makoto Takeuchi ,  Takamitsu Himeno

IPC: F01C1/04

CPC classification number: F04C18/0215 ,  F01C21/02 ,  F01C21/10 ,  F04C29/0057 ,  F04C2230/21 ,  F04C2240/30 ,  F16C2360/42

Abstract: There is provided a fluid machine able to secure a sectional area of a passage sufficient for gaseous fluid flow from a suction port to a compression mechanism, while able at the same time to achieve a reduction in size of the outline shape. In a scroll compressor where a scroll compression mechanism 23 is housed within a housing 3 having a funnel shaped, a compression mechanism main body of the scroll compression mechanism 23 is arranged in a wide opening section of a front housing 5, and a compression mechanism driving section is arranged in a narrow section, a concave section 51 is formed on the outside of a thrust receiving surface 5B which is positioned on a bottom surface of the wide opening section and which supports the compression mechanism.

Abstract translation: 提供了一种流体机械，其能够固定足以使气体流体从吸入口流到压缩机构的通道的截面面积，同时能够实现轮廓形状的尺寸的减小。 在涡卷压缩机构23容纳在具有漏斗形状的壳体3内的涡旋压缩机中，涡旋压缩机构23的压缩机构主体配置在前壳体5的宽开口部，驱动压缩机构 截面布置在狭窄部分中，凹部51形成在位于宽开口部的底面上并支撑压缩机构的推力接收面5B的外侧。

公开(公告)号：US07273597B2

公开(公告)日：2007-09-25

申请号：US10695225

申请日：2003-10-28

Applicant: Makoto Takeuchi ,  Katsumi Koike ,  Akinori Mogami ,  Takamichi Maruyama

Inventor： Makoto Takeuchi ,  Katsumi Koike ,  Akinori Mogami ,  Takamichi Maruyama

IPC: C01B31/02

CPC classification number: H01G11/34 ,  H01G11/24 ,  H01G11/38 ,  H01G11/60 ,  H01G11/62 ,  Y02E60/13 ,  Y02T10/7022 ,  Y10T29/417

Abstract: The present invention provides a novel carbon material for a electric double-layer capacitor having characteristics entirely different from prior art activated carbon. The capacitor develops a capacitance by a mechanism entirely different from the mechanism of an electric double-layer capacitor using activated carbon. The novel capacitor has improved performance including capacitance. The capacitor has polarized electrodes immersed in an organic electrolyte. The electrodes are made of a nonporous carbon having crystallites of graphite-like carbon. When a voltage is applied, electrolyte ions are intercalated between the layers of the crystallites of the graphite-like carbon together with the solvent. Thus, electric double layers are formed. Intercalation is induced by the first cycle of charging. In the second and following cycles, the capacitance is developed.

Abstract translation: 本发明提供了一种具有与现有技术活性炭完全不同的特征的双电层电容器的新型碳材料。 该电容器通过与使用活性炭的双电层电容器的机理完全不同的机构产生电容。 新颖的电容器具有改善的性能，包括电容。 该电容器具有浸入有机电解质中的极化电极。 电极由具有石墨状碳的微晶的无孔碳制成。 当施加电压时，电解质离子与溶剂一起插入石墨状碳的微晶层之间。 因此，形成双电层。 插入由第一次充电循环引起。 在第二个和以后的周期中，开发电容。

公开(公告)号：US07180725B2

公开(公告)日：2007-02-20

申请号：US10547495

申请日：2004-03-03

Applicant: Makoto Takeuchi ,  Akinori Mogami ,  Katsumi Koike

Inventor： Makoto Takeuchi ,  Akinori Mogami ,  Katsumi Koike

IPC: H01G9/00 ,  H01G9/02

CPC classification number: H01G9/038 ,  H01G9/155 ,  H01G11/24 ,  H01G11/60 ,  H01G11/62 ,  Y02E60/13 ,  Y02T10/7022

Abstract: Present invention relates to an electric double-layer capacitor having positive and negative electrodes containing nonporous carbon as an electrode active material. In the nonporous carbon, multiple layers of graphene having an average interplanar spacing d002 of 0.350 to 0.380 nm have been grown well. The positive and negative electrodes are impregnated with an electrolyte solution. The nonporous carbon is obtained by activating easily graphitizable carbon, which in turn is obtained by calcining needle coke or pitch made infusible. The elctrolyte solution is either a liquid electrolyte having a planar molecular structure or an electrolyte solution consisting of a liquid electrolyte dissolved in an organic solvent.

Abstract translation: 本发明涉及具有含有无孔碳作为电极活性物质的正极和负极的双电层电容器。 在无孔碳中，已经良好地生长了具有0.350至0.380nm的平均晶面间距d 002 002的多层石墨烯。 正极和负极用电解质溶液浸渍。 通过活化容易石墨化的碳而获得无孔碳，其又通过煅烧针状焦炭或沥青而形成的不可渗透性而获得。 电解质溶液是具有平面分子结构的液体电解质或由溶解在有机溶剂中的液体电解质组成的电解质溶液。

公开(公告)号：US20060205770A1

公开(公告)日：2006-09-14

申请号：US11128238

申请日：2005-05-13

Applicant: Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

Inventor： Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

IPC: C07D453/02 ,  A61K31/4745

CPC classification number: C07D453/02

Abstract: There is provided an acid addition salt of (−)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (−)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(4-methylbenzoyl)tartaric acid, (−)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has little hygroscopicity that affects the use as a drug or its drug substance, and is very useful as a drug or its drug substance.

Abstract translation: 提供了（ - ） - （3R） - 奎宁环-3-基（1R）-1-苯基-1,2,3,4-四氢异喹啉-2-羧酸的酸加成盐，其中酸选自 的（ - ） - （2S，3S） - 酒石酸，（+） - （2S，3S） - 二-O-苯甲酰基酒石酸，（+） - （2S，3S） - 二-O-（4-甲基苯甲酰基） 酒石酸，（ - ） - L-苯丙氨酸，苯磺酸，环己烷氨基磺酸，氢溴酸，萘-2-磺酸，癸二酸，（+） - 樟脑-10-磺酸，对甲苯磺酸，乙磺酸，甲磺酸 酸和磷酸甲酯，其吸湿性几乎不影响作为药物或其药物物质的用途，并且作为药物或其药物物质是非常有用的。