公开(公告)号：US09517677B2

公开(公告)日：2016-12-13

申请号：US13702954

申请日：2011-05-19

申请人： Masaaki Tokuda ,  Shinichirou Mizoguchi ,  Satoshi Ogihara

发明人： Masaaki Tokuda ,  Shinichirou Mizoguchi ,  Satoshi Ogihara

IPC分类号： B60H1/00 ,  B60H1/14 ,  B60L1/00

CPC分类号： B60H1/00007 ,  B60H1/00278 ,  B60H1/143 ,  B60H2001/00307 ,  B60L1/003 ,  B60L2240/34 ,  B60L2240/36 ,  B60L2240/662 ,  Y02T10/7291 ,  Y02T90/16

摘要： A vehicle air conditioning system includes a duct, a refrigerant evaporator, an air conditioning cooling flow passage, a heater core, a heater hot fluid flow passage, a heat exchanger, an electric heater, an electrical component cooling flow passage, a communication flow passage, a fluid temperature sensor and a flow passage selector valve. The duct provides air to a vehicle cabin interior. The cooling flow passage provides cooled refrigerant to the evaporator. The hot fluid flow passage provides hot fluid to the heater core. The heat exchanger exchanges heat between the refrigerant and the hot fluid. The heater warms the hot fluid having undergone heat exchange. The cooling flow passage cools an electrical component. The communication flow passage parallelly connects the hot fluid and electrical component flow passages. The valve allows hot fluid to flow into the cooling flow passage when the hot fluid has a high temperature.

摘要翻译： 一种车辆空调系统，包括管道，制冷剂蒸发器，空调冷却流路，加热器芯，加热器热流体流路，热交换器，电加热器，电气部件冷却流路，连通流路 ，流体温度传感器和流路切换阀。 管道为车厢内部提供空气。 冷却流路将冷却的制冷剂提供给蒸发器。 热流体流动通道将热流体提供给加热器芯。 热交换器在制冷剂和热流体之间交换热量。 加热器加热经过热交换的热流体。 冷却流路冷却电气部件。 连通流路并流连接热流体和电气部件流动通道。 当热流体具有高温时，阀允许热流体流入冷却流道。

公开(公告)号：US20150320093A1

公开(公告)日：2015-11-12

申请号：US14345479

申请日：2014-01-31

申请人： Masaaki Tokuda ,  Koji Murao ,  Noritsugu Hishitani

发明人： Masaaki Tokuda ,  Koji Murao ,  Noritsugu Hishitani

IPC分类号： A23L1/214 ,  A23L1/09 ,  A23L2/52 ,  A23L1/30 ,  A23L2/02

CPC分类号： A23L21/00 ,  A23L2/02 ,  A23L2/52 ,  A23L5/00 ,  A23L19/115 ,  A23L29/30 ,  A23L33/00 ,  A23L33/105 ,  A23L33/125

摘要： A processed konjac food having blood glucose increase suppressing effect is provided. The processed konjac food having blood glucose increase suppressing effect contains a konjac having a pH in a range of 2.5 to 7.4 and a rare sugar as active ingredients, is intended for ingestion of the rare sugar at a daily dose of 0.3 to 50 g/day for suppressing blood glucose increase, and is shaped into a rectangular, thread, round, grain, or plate form. The blood glucose increase effect can last for at least one day after one-time ingestion. For example, by making a konjac containing a rare sugar into a processed food, the product can be adapted to any consumer preferences without impediment upon eating or drinking, and therefore, a long-term ingestion is facilitated and the blood glucose increase suppressing effect can be sustained for a long period.

摘要翻译： 提供了具有增加血糖的抑制效果的加工的魔芋食品。 具有血糖增加抑制效果的加工的魔芋食品含有pH为2.5〜7.4的稀土和作为活性成分的稀有糖的魔芋用于以0.3〜50g /日的日剂量摄取稀有糖 用于抑制血糖升高，并且被成形为矩形，螺纹，圆形，谷物或板形。 一次摄入后，血糖升高效果可持续至少1天。 例如，通过将含有稀有糖的魔芋制成加工食品，该产品可以适应任何消费者的喜好而不会在饮食或饮食上受到阻碍，因此长期摄入便于促进血糖增加抑制作用 持续很长时间。

公开(公告)号：US08420606B2

公开(公告)日：2013-04-16

申请号：US13007058

申请日：2011-01-14

申请人： Ken Izumori ,  Masaaki Tokuda ,  Toshifumi Itano ,  Osamu Miyamoto ,  Toshihiko Ishida ,  Koji Murao ,  Taizo Tasaka ,  Gan Muneuchi ,  Fuminori Yamaguchi ,  Terukazu Tanaka ,  Masaaki Ueki ,  Kazuyuki Hirooka ,  Tomohiko Taminato ,  Mohammad A. Hossain ,  Keiji Tsusaki ,  Takeo Takahashi ,  Mitsuhiro Nagata ,  Yutaka Ishida

发明人： Ken Izumori ,  Masaaki Tokuda ,  Toshifumi Itano ,  Osamu Miyamoto ,  Toshihiko Ishida ,  Koji Murao ,  Taizo Tasaka ,  Gan Muneuchi ,  Fuminori Yamaguchi ,  Terukazu Tanaka ,  Masaaki Ueki ,  Kazuyuki Hirooka ,  Tomohiko Taminato ,  Mohammad A. Hossain ,  Keiji Tsusaki ,  Takeo Takahashi ,  Mitsuhiro Nagata ,  Yutaka Ishida

IPC分类号： A61K31/7004 ,  A61K31/70

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

摘要翻译： 利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。 作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。 细胞是人细胞。 组合物是功能性食品，药物或化妆品。 罕见的糖是属于醛糖和/或酮糖的稀有糖。 醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。 酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

公开(公告)号：US20130012459A1

公开(公告)日：2013-01-10

申请号：US13547604

申请日：2012-07-12

申请人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

发明人： Masaaki Tokuda ,  Kouji Murao ,  Toshihiko Ishida ,  Ken Izumori

IPC分类号： A61K31/7004 ,  A61P9/10

CPC分类号： A23K20/163 ,  A23L33/10 ,  A61K31/7004

摘要： A composition for inhibiting the onset of arteriosclerosis is characterized by comprising D-psicose as an active ingredient for an antiatherogenic action. The antiatherogenic action as described above includes an action of inhibiting or reducing the expression of a chemokine or a cytokine related to arteriosclerosis in vivo and an action of promoting the expression of a receptor involved in the improvement of arteriosclerosis without affecting the expression of an arteriosclerosis inducer. This composition is used in the form of a product selected from the group consisting of sweeteners, seasonings, food additives, food materials, foods and drinks, health foods and drinks, drugs, quasi drugs and feeds blended with D-psicose and/or its derivative and/or a mixture thereof as the active ingredient. The method of inhibiting the onset of arteriosclerosis is a method of using the above composition.

摘要翻译： 用于抑制动脉硬化发作的组合物的特征在于包含D-灵敏蛋白作为抗动脉粥样硬化作用的活性成分。 如上所述的抗动脉粥样硬化作用包括抑制或降低与体内动脉硬化相关的趋化因子或细胞因子的表达的作用，以及促进动脉硬化改善的受体的表达的作用，而不影响动脉硬化诱导剂的表达 。 该组合物以选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料，保健食品和饮料，药物，准药物和掺有D-psicose和/或其混合物的饲料的形式使用 衍生物和/或其混合物作为活性成分。 抑制动脉硬化发生的方法是使用上述组合物的方法。

公开(公告)号：US20100294217A1

公开(公告)日：2010-11-25

申请号：US12863956

申请日：2009-01-19

申请人： Junichiro Kasuya ,  Satoshi Ogiwara ,  Masaaki Tokuda ,  Tomohiko Saito

发明人： Junichiro Kasuya ,  Satoshi Ogiwara ,  Masaaki Tokuda ,  Tomohiko Saito

IPC分类号： F01P11/00

CPC分类号： F02G5/04 ,  F01K9/003 ,  F01K15/02 ,  F01K23/065 ,  F01N5/02 ,  F02G2260/00 ,  Y02T10/16 ,  Y02T10/166

摘要： A waste heat utilization device for an internal combustion engine (2) comprising a cooling water circuit (4) including a radiator (12) for cooling cooling-water by means of outside air drawn to pass through the radiator, a Rankine cycle (6) including a first condenser (24) for condensing a refrigerant, and a refrigeration cycle (8) including a second condenser (36) for condensing a refrigerant, wherein the first and second condensers (24, 36) are water-cooled heat exchangers, and the waste heat utilization device includes a water circuit (44) including an air-cooled heat exchanger (46) for cooling water that has passed through the first and second condensers (24, 36), by means of outside air drawn to pass through the air-cooled heat exchanger, and a heat exchange unit composed of the air-cooled heat exchanger (46) and the radiator (12).

摘要翻译： 一种用于内燃机（2）的废热利用装置，包括冷却水回路（4），冷却水回路（4）包括用于通过被抽吸以通过散热器的外部空气冷却冷却水的散热器（12），兰金循环（6） 包括用于冷凝制冷剂的第一冷凝器（24）和包括用于冷凝制冷剂的第二冷凝器（36）的制冷循环（8），其中所述第一和第二冷凝器（24,36）是水冷式热交换器，以及 废热利用装置包括水回路（44），其包括用于冷却已经通过第一和第二冷凝器（24,36）的水的空气冷却热交换器（46），借助于外部空气被抽吸以通过第 风冷式热交换器和由风冷式热交换器46和散热器12构成的热交换单元。

公开(公告)号：US20100222285A1

公开(公告)日：2010-09-02

申请号：US12775807

申请日：2010-05-07

申请人： Masaaki Tokuda ,  Ikuko Tsukamoto ,  Ryoji Konishi ,  Yasuo Kubota ,  Ken Izumori

发明人： Masaaki Tokuda ,  Ikuko Tsukamoto ,  Ryoji Konishi ,  Yasuo Kubota ,  Ken Izumori

IPC分类号： A61K31/7004 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07H3/08 ,  A23L33/10 ,  A61K31/7004 ,  C07H3/02

摘要： A specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation is disclosed. This rare sugar is provided as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. The proliferation of vascular endothelial cells is controlled utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. Lumen formation of vascular endothelial cells is inhibited by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-glucose, D-talose, L-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

摘要翻译： 公开了具有抑制血管内皮细胞增殖和内膜形成的作用的特定稀有糖。 这种罕见的糖被提供作为血管生成疾病，化妆品或功能性食物的预防/补救。 血管内皮细胞的增殖受D-甘露糖，D-丙氨酸，2-脱氧-D-葡萄糖，3-脱氧-D-葡萄糖，L-山梨糖，2-脱氧-D-葡萄糖，L-山梨糖， D-核糖和/或2-脱氧-L-核糖。 通过利用D-阿洛糖，D-阿糖，D-葡萄糖，D-塔洛糖，L-阿洛糖，2-脱氧-D-葡萄糖，3-甲氧基-D-葡萄糖， 脱氧-D-葡萄糖，D-核糖，L-核糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。

公开(公告)号：US20100167350A1

公开(公告)日：2010-07-01

申请号：US12515602

申请日：2007-03-27

申请人： Ken Izumori ,  Kenji Morimoto ,  Goro Takata ,  Masaaki Tokuda ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

发明人： Ken Izumori ,  Kenji Morimoto ,  Goro Takata ,  Masaaki Tokuda ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

IPC分类号： C12P19/00 ,  C07H3/08 ,  C12N1/20

CPC分类号： C12R1/01 ,  A61K8/60 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/0006 ,  C12P19/02

摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.

摘要翻译： 问题：提供具有生产脱氧多元醇脱氢酶能力的微生物。 解决方法：属于肠杆菌属的微生物，其在位置C2和C3处产生与核糖醇或L-阿托糖醇相同结构的脱氧多羟基化脱氢酶的能力。 肠杆菌属细菌细胞IK7（登录号NITE P-271）。 一种生产脱氧酮糖酮的方法，包括使含有通过培养本发明的微生物获得的脱氧多元醇脱氢酶的培养物或使脱氧多元醇脱氢酶与位置C2和C3处于相同结构的含有脱氧多羟基化合物的溶液反应，作为 核糖醇或L-天冬氨酸氧化脱氧多元醇以产生相应的脱氧酮糖，然后收集脱氧酮糖酮。 脱氧多元醇是1-脱氧-D-多糖，而相应的脱氧酮基是1-脱氧-L-精氨酸。 否则，脱氧多元醇为L-麦芽糖醇，而相应的脱氧酮糖为1-脱氧-L-果糖。

公开(公告)号：US20100166678A1

公开(公告)日：2010-07-01

申请号：US12514182

申请日：2007-03-27

申请人： Tetsuo Iida ,  Takashi Ichihara ,  Ken Izumori ,  Masaaki Tokuda ,  Takaaki Ogawa

发明人： Tetsuo Iida ,  Takashi Ichihara ,  Ken Izumori ,  Masaaki Tokuda ,  Takaaki Ogawa

IPC分类号： A61K8/60 ,  A61Q11/00

CPC分类号： A61K8/60 ,  A61K31/047 ,  A61K31/7004 ,  A61Q11/00 ,  C07H3/02

摘要： Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor.Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.

摘要翻译： 目的：提供一种用于预防牙周病（牙周病的预防剂）的组合物，该组合物具有优异的抑制性，对于长时间使用是安全和稳定的并且对风味的影响较小。 解决方法：通过将选自D-木糖，D-山梨糖和D-塔格糖的D-形式的稀有糖混合制备的非致龋材料，L型的稀有糖选自L- 果糖，L-灵巧蛋白和L-塔格糖，或作为稀有糖衍生物的全醇，单独或组合使用。 包含D-灵糖蛋白，D-山梨糖，D-塔格糖，L-果糖，L-灵巧蛋白和/或L-塔格糖的抑制剂。 与儿茶素组合使用的抑菌剂。

公开(公告)号：US20100105885A1

公开(公告)日：2010-04-29

申请号：US12515605

申请日：2007-11-20

申请人： Ken Izumori ,  Masaaki Tokuda ,  George Fleet ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

发明人： Ken Izumori ,  Masaaki Tokuda ,  George Fleet ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

IPC分类号： C07H3/02 ,  C12N9/90 ,  C12P19/24

CPC分类号： C07H3/02 ,  C12N9/92 ,  C12P19/24

摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.

摘要翻译： 提供对应于所有醛脱水己酮糖，酮己立糖和糖醇的1-脱氧产物或6-脱氧产物，以脱氧消肿为基础，以及一种系统地生产这些产品的方法。 使用衍生自奇异假单胞菌ST-24（FERM BP-2736）的脱氧己糖异构酶生产脱氧己糖及其衍生物的方法，其包括将1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或 6-脱氧L-酮基己糖，以产生单独相应的1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或6-脱氧L-酮己糖作为目标产物。

公开(公告)号：US20090304891A1

公开(公告)日：2009-12-10

申请号：US12514216

申请日：2007-03-26

申请人： Hideki Fujihara ,  Kazuhiro Okuma ,  Tetsuo Iida ,  Ken Izumori ,  Masaaki Tokuda ,  Kazuhiro Fukuda

发明人： Hideki Fujihara ,  Kazuhiro Okuma ,  Tetsuo Iida ,  Ken Izumori ,  Masaaki Tokuda ,  Kazuhiro Fukuda

IPC分类号： A23L1/236

CPC分类号： A23C9/13 ,  A23G3/36 ,  A23G3/42 ,  A23G4/06 ,  A23G4/10 ,  A23L2/60 ,  A23L27/33 ,  A61K8/60 ,  A61K47/26 ,  A61Q11/00

摘要： Providing a D-psicose-containing sweetener with the modification of the taste of D-psicose, comprising D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.

摘要翻译： 提供具有D-灵糖蛋白的甜味剂，其具有改性的D-psicose的味道，包括D-肉豆蔻糖，糖醇和/或高强度甜味剂，优选含有D-灵敏蛋白作为主要成分，特别是低热量 甜味剂和/或甜味剂在口腔中提供清爽的感觉，以及通过使用含有D-psicose的甜味剂获得的食品和饮料以及D-psicose的味道的改变以及其它赋予甜味的产品。 糖醇是选自山梨糖醇，甘露糖醇，乳糖醇，麦芽糖醇，木糖醇和赤藓糖醇的一种或多种糖醇，而高强度甜味剂是选自阿斯巴甜，乙酰磺胺酸钾，环己烷氨基磺酸钠的一种或多种高强度甜味剂， 糖精钠，三氯蔗糖（商品名），甜叶菊甜味剂，葫芦素，桃黄素，纽甜和莫奈林。