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    Medical device with porous surface for controlled drug release and method of making the same
    112.
    发明授权
    Medical device with porous surface for controlled drug release and method of making the same 有权
    具有多孔表面的医疗装置用于受控药物释放及其制备方法

    公开(公告)号：US07758909B2

    公开(公告)日：2010-07-20

    申请号：US11851675

    申请日：2007-09-07

    Applicant: Ni Ding

    Inventor： Ni Ding

    IPC: B05D1/00

    CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42

    Abstract: The medical devices of the invention comprise a portion having a porous surface for release of at least one biologically active agent therefrom. The porous surface is made of a material such as a polymer having a plurality of voids. To load the porous surface with a biologically active agent or drug, an electrophoresis method is employed. In this method, a device having a porous surface is placed into a drug solution or suspension, along with an electrode. An electric current is applied to the device and electrode. Under such a current, the drug, which has a positive or negative charge, will be loaded into the pores or voids of the porous surface.

    Abstract translation: 本发明的医疗装置包括具有用于从其释放至少一种生物活性剂的多孔表面的部分。 多孔表面由诸如具有多个空隙的聚合物的材料制成。 为了用生物活性剂或药物加载多孔表面，使用电泳方法。 在该方法中，具有多孔表面的装置与电极一起放入药液或悬浮液中。 电流被施加到器件和电极上。 在这样的电流下，具有正电荷或负电荷的药物将被加载到多孔表面的孔或空隙中。

    DRUG DELIVERY COMPOSITIONS AND MEDICAL DEVICES CONTAINING BLOCK COPOLYMER
    114.
    发明申请
    DRUG DELIVERY COMPOSITIONS AND MEDICAL DEVICES CONTAINING BLOCK COPOLYMER 有权
    药物递送组合物和含有嵌段共聚物的医疗装置

    公开(公告)号：US20100092540A1

    公开(公告)日：2010-04-15

    申请号：US12578362

    申请日：2009-10-13

    Applicant: Leonard Pinchuk ,  Sepideh Hashemi ,  Marlene C. Schwarz ,  Kalpana Kamath ,  Ni Ding

    Inventor： Leonard Pinchuk ,  Sepideh Hashemi ,  Marlene C. Schwarz ,  Kalpana Kamath ,  Ni Ding

    IPC: A61F2/00 ,  A61K31/337 ,  A61P35/00

    CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

    Abstract: A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

    Abstract translation: 提供了用于递送治疗剂的组合物。 所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。 嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。 弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。 根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。 医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。 根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。 根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层 包括上述生物相容性嵌段共聚物。

    Drug delivery compositions and medical devices containing block copolymer
    115.
    发明授权
    Drug delivery compositions and medical devices containing block copolymer 有权
    药物输送组合物和含有嵌段共聚物的医疗器械

    公开(公告)号：US07622530B2

    公开(公告)日：2009-11-24

    申请号：US11057870

    申请日：2005-02-14

    Applicant: Leonard Pinchuk ,  Sepideh Hashemi ,  Marlene C. Schwarz ,  Kalpana Kamath ,  Ni Ding

    Inventor： Leonard Pinchuk ,  Sepideh Hashemi ,  Marlene C. Schwarz ,  Kalpana Kamath ,  Ni Ding

    IPC: C08L33/02 ,  A61F2/00

    CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

    Abstract: A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

    Abstract translation: 提供了用于递送治疗剂的组合物。 所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。 嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。 弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。 根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。 医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。 根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。 根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层 包括上述生物相容性嵌段共聚物。

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