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119 条记录 (耗时 0.033 秒)

    Pulsed laser processing with controlled thermal and physical alterations
    111.
    发明申请
    Pulsed laser processing with controlled thermal and physical alterations 有权
    脉冲激光加工具有受控的热和物理改变

    公开(公告)号：US20050218122A1

    公开(公告)日：2005-10-06

    申请号：US10813389

    申请日：2004-03-31

    申请人： Tadashi Yamamoto ,  Donald Harter ,  Rajesh Patel ,  Alan Arai

    发明人： Tadashi Yamamoto ,  Donald Harter ,  Rajesh Patel ,  Alan Arai

    IPC分类号： B23K26/00 ,  B23K26/06

    CPC分类号： B23K26/0624 ,  B23K26/0622

    摘要： A method for laser machining of material using a burst comprised of laser pulses. The method tailors the pulse width, pulse separation duration, wavelength and polarization of the multiple laser pulses included in a burst to maximize the positive effect of thermal and physical changes achieved by previous pulses that have impinged upon the machined material.

    摘要翻译： 使用由激光脉冲组成的脉冲激光加工材料的方法。 该方法调整脉冲包括的脉冲宽度，脉冲间隔持续时间，波长和多个激光脉冲的极化，以最大限度地发挥已经冲击加工材料的先前脉冲实现的热和物理变化的积极作用。

    Quantitative determination of nucleic acid amplification products
    114.
    发明授权
    Quantitative determination of nucleic acid amplification products 失效

    公开(公告)号：US06573054B2

    公开(公告)日：2003-06-03

    申请号：US10043415

    申请日：2002-01-10

    申请人： Rajesh Patel ,  Nurith Kurn

    发明人： Rajesh Patel ,  Nurith Kurn

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6851 ,  C12Q1/6818 ,  C12Q2565/519 ,  C12Q2527/101

    摘要： The present invention relates to a method for detecting the amount of a target polynucleotide in a sample. A combination is provided in a medium. The combination comprises (i) a sample suspected of containing the target polynucleotide, the target polynucleotide being in single stranded form, (ii) a reference polynucleotide comprising a sequence that is common with a sequence of the target polynucleotide, and (iii) a predetermined amount of an oligonucleotide probe that has a sequence that hybridizes with the sequence that is common. The combination is subjected to conditions for amplifying the target polynucleotide and the reference polynucleotide. The conditions permit formation of substantially non-dissociative complexes of the target polynucleotide and the reference polynucleotide, respectively, with the oligonucleotide probe. Furthermore, the predetermined amount of the oligonucleotide probe is less than the expected amount of the amplified target polynucleotide. The ratio of the amount of the complex of the target polynucleotide with the oligonucleotide probe to the amount of the complex of the reference polynucleotide with the oligonucleotide probe is determined. Determination of the ratio is facilitated by employing second and third oligonucleotide probes. The second oligonucleotide probe has a sequence that hybridizes only with the second sequence of the target polynucleotide. The third oligonucleotide probe has a sequence that hybridizes only with a respective second sequence of the reference polynucleotide. The ratio is related to the known amount of the reference polynucleotide to determine the amount of the target polynucleotide in the sample. One or more reference polynucleotides may be employed with a corresponding third oligonucleotide probe for each reference probe. Kits for carrying out the above methods are also disclosed. The method is particularly applicable to the amplification and detection of RNA.

    Plasticized bioerodible controlled delivery system
    116.
    发明授权
    Plasticized bioerodible controlled delivery system 失效
    塑化生物可蚀性控制输送系统

    公开(公告)号：US06372245B1

    公开(公告)日：2002-04-16

    申请号：US08233211

    申请日：1994-04-22

    申请人： Lyle M. Bowman ,  Santosh Kumar Chandrasekaran ,  Rajesh Patel ,  Hoa Vinh Vo

    发明人： Lyle M. Bowman ,  Santosh Kumar Chandrasekaran ,  Rajesh Patel ,  Hoa Vinh Vo

    IPC分类号： A61K910

    CPC分类号： A61K9/0048 ,  A61K47/34 ,  Y10S514/912

    摘要： A controlled release medicament delivery system comprises a plasticized bioerodible polymer, such as a polyorthoester. Medicament desirably is entrapped in the plasticized polymer. The resulting delivery system is able to release the medicament in a controlled and sustained manner. The formulation is particularly advantageous for use as a once-a-day eyedrop. During preparation, the polymer may be heated to an elevated temperature for a sufficient time to substantially reduce its molecular weight.

    摘要翻译： 控释药物递送系统包括增塑的生物可腐蚀聚合物，例如聚原酸酯。 药物期望地被包埋在增塑聚合物中。 所得到的递送系统能够以受控和持续的方式释放药物。 该制剂特别有利于用作一日一次的眼药水。 在制备过程中，可将聚合物加热至高温足够的时间以显着降低其分子量。

    Quantitative determination of nucleic acid amplification products
    117.
    发明授权
    Quantitative determination of nucleic acid amplification products 失效

    公开(公告)号：US06365346B1

    公开(公告)日：2002-04-02

    申请号：US09025639

    申请日：1998-02-18

    申请人： Rajesh Patel ,  Nurith Kurn

    发明人： Rajesh Patel ,  Nurith Kurn

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6851 ,  C12Q1/6818 ,  C12Q2565/519 ,  C12Q2527/101

    摘要： The present invention relates to a method for detecting the amount of a target polynucleotide in a sample. A combination is provided in a medium. The combination comprises (i) a sample suspected of containing the target polynucleotide, the target polynucleotide being in single stranded form, (ii) a reference polynucleotide comprising a sequence that is common with a sequence of the target polynucleotide, and (iii) a predetermined amount of an oligonucleotide probe that has a sequence that hybridizes with the sequence that is common. The combination is subjected to conditions for amplifying the target polynucleotide and the reference polynucleotide. The conditions permit formation of substantially non-dissociative complexes of the target polynucleotide and the reference polynucleotide, respectively, with the oligonucleotide probe. Furthermore, the predetermined amount of the oligonucleotide probe is less than the expected amount of the amplified target polynucleotide. The ratio of the amount of the complex of the target polynucleotide with the oligonucleotide probe to the amount of the complex of the reference polynucleotide with the oligonucleotide probe is determined. Determination of the ratio is facilitated by employing second and third oligonucleotide probes. The second oligonucleotide probe has a sequence that hybridizes only with the second sequence of the target polynucleotide. The third oligonucleotide probe has a sequence that hybridizes only with a respective second sequence of the reference polynucleotide. The ratio is related to the known amount of the reference polynucleotide to determine the amount of the target polynucleotide in the sample. One or more reference polynucleotides may be employed with a corresponding third oligonucleotide probe for each reference probe. Kits for carrying out the above methods are also disclosed. The method is particularly applicable to the amplification and detection of RNA.

    Dynamically modifying queued transactions in a cache memory system
    118.
    发明授权
    Dynamically modifying queued transactions in a cache memory system 失效
    动态修改缓存内存系统中的排队事务

    公开(公告)号：US06321303B1

    公开(公告)日：2001-11-20

    申请号：US09271492

    申请日：1999-03-18

    申请人： Thomas Alan Hoy ,  Belliappa Manavattira Kuttanna ,  Rajesh Patel ,  Michael Dean Snyder

    发明人： Thomas Alan Hoy ,  Belliappa Manavattira Kuttanna ,  Rajesh Patel ,  Michael Dean Snyder

    IPC分类号： G06F1208

    CPC分类号： G06F12/0831

    摘要： A computer and its corresponding cache system includes a cache memory, a buffer unit, and a bus transaction queue. The buffer unit includes a plurality of entries suitable for temporarily storing data, address, and attribute information of operations generated by the CPU. A first operation initiated by the load store unit buffers an operation in a first entry of the buffer unit, which initiates a first transaction to be queued in a first entry of the bus transaction queue where the first transaction in the bus transaction queue points to the first entry in the buffer unit. Preferably, the buffer unit is configured to modify the first transaction from a first transaction type to a second transaction type prior to execution in response to an event that alters the data requirements of the queued transaction. Additional utility is achieved by merging multiple store operation that miss to a common cache line into a single entry. Further benefits is achieved by allowing multiple load misses to the same cache line to be completed from a buffer that reduces cache pipeline stalls.

    摘要翻译： 计算机及其对应的缓存系统包括高速缓冲存储器，缓冲器单元和总线事务队列。 缓冲单元包括适于临时存储由CPU生成的操作的数据，地址和属性信息的多个条目。 由加载存储单元启动的第一操作缓冲在缓冲单元的第一条目中的操作，该操作启动要在总线事务队列的第一条目中排队的第一事务，其中总线事务队列中的第一事务指向 缓冲单元中的第一个条目。 优选地，缓冲单元被配置为响应于改变排队交易的数据需求的事件，在执行之前将第一事务从第一事务类型修改为第二事务类型。 通过将多个存储操作错过公用高速缓存行合并到单个条目中来实现附加效用。 通过允许从减少高速缓存管道停顿的缓冲器中完成相同高速缓存行的多个加载错误来实现进一步的益处。