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    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR NEUROLOGICAL HEALTH ISSUES
    111.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR NEUROLOGICAL HEALTH ISSUES 审中-公开
    微生物衍生诊断方法与系统及神经保健问题的治疗方法

    公开(公告)号：US20170039347A1

    公开(公告)日：2017-02-09

    申请号：US15294482

    申请日：2016-10-14

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Belbahani

    IPC: G06F19/00 ,  A61K35/742 ,  A61K45/06 ,  A61K35/744 ,  A61K35/745 ,  A61K35/741 ,  A61K35/747

    CPC classification number: G16H20/40 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K45/06 ,  G06F19/3481 ,  G16B20/00 ,  G16B30/00 ,  G16B50/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/70 ,  Y02A90/26

    Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗神经性健康问题的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征，产生神经健康问题的表征; 基于表征，产生配置以校正神经系统健康问题的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

    METHOD AND SYSTEM FOR DIAGNOSTIC TESTING
    112.
    发明申请
    METHOD AND SYSTEM FOR DIAGNOSTIC TESTING 审中-公开
    用于诊断测试的方法和系统

    公开(公告)号：US20170002432A1

    公开(公告)日：2017-01-05

    申请号：US15198818

    申请日：2016-06-30

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid

    IPC: C12Q1/70 ,  A61B10/00

    Abstract: An embodiment of a method for diagnostic testing includes: providing a sampling kit to a subject, the sampling kit including a sample container for reception of a sample from a collection site of the subject; receiving the sample from the subject; generating a microbiome sequence dataset based upon sequencing nucleic acid content of a microorganism portion of the sample; detecting a presence of a set of microbiome targets; generating a diagnostic analysis based on the detected set of microbiome targets; generating a therapy recommendation based on the set of microbiome targets; and promoting the therapy recommendation in coordination with presenting information derived from the diagnostic analysis.

    Abstract translation: 用于诊断测试的方法的实施例包括：向受试者提供采样套件，所述采样套件包括用于从所述受试者的收集部位接收样品的样本容器; 从受试者接收样本; 基于样品的微生物部分的核酸含量测定产生微生物群序列数据集; 检测一组微生物靶标的存在; 基于检测到的一组微生物群目标产生诊断分析; 基于一组微生物靶标产生治疗推荐; 并与介绍从诊断分析中得出的信息配合推广治疗推荐。

    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ENDOCRINE SYSTEM CONDITIONS
    113.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ENDOCRINE SYSTEM CONDITIONS 审中-公开

    公开(公告)号：US20160319358A1

    公开(公告)日：2016-11-03

    申请号：US15207930

    申请日：2016-07-12

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

    IPC: C12Q1/68 ,  G06F19/14 ,  A61K35/741 ,  G06F19/28

    Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ENDOCRINE SYSTEM CONDITIONS
    114.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ENDOCRINE SYSTEM CONDITIONS 有权
    微生物衍生物诊断方法与系统及内分泌系统条件的治疗方法

    公开(公告)号：US20160232313A1

    公开(公告)日：2016-08-11

    申请号：US15098248

    申请日：2016-04-13

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

    IPC: G06F19/00 ,  G06F19/28 ,  C12Q1/68 ,  G06F19/12

    CPC classification number: G06F19/22 ,  C12Q1/689 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/16 ,  G06F19/00 ,  G06F19/12 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3418 ,  G06F19/3456 ,  G16H50/20 ,  Y02A90/26

    Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗内分泌系统状况的方法，所述方法包括：从受试者群体接收聚集的一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征产生内分泌系统状况的表征; 基于表征，产生配置用于校正内分泌系统状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR AUTOMIMMUNE SYSTEM CONDITIONS
    116.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR AUTOMIMMUNE SYSTEM CONDITIONS 审中-公开
    用于自动化系统条件的微生物衍生诊断和治疗方法和系统

    公开(公告)号：US20160224748A1

    公开(公告)日：2016-08-04

    申请号：US15098027

    申请日：2016-04-13

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

    IPC: G06F19/00 ,  G06F19/12 ,  G06F19/28 ,  C40B30/02

    CPC classification number: G06F19/345 ,  C40B30/02 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3418 ,  G16H50/20 ,  Y02A90/26

    Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗自身免疫疾病的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征产生自身免疫病症的表征; 基于表征，产生配置用于校正自身免疫状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

    METHOD AND SYSTEM FOR FRAGMENT ASSEMBLY AND SEQUENCE IDENTIFICATION
    118.
    发明申请
    METHOD AND SYSTEM FOR FRAGMENT ASSEMBLY AND SEQUENCE IDENTIFICATION 审中-公开

    公开(公告)号：US20190237159A1

    公开(公告)日：2019-08-01

    申请号：US16376355

    申请日：2019-04-05

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Rodrigo Ortiz

    IPC: G16B30/00 ,  C12N15/10 ,  C40B50/06

    CPC classification number: G16B30/00 ,  C12N15/1065 ,  C12N15/1093 ,  C12Q1/6869 ,  C12Q2600/156 ,  C40B50/06 ,  G16B30/20

    Abstract: Embodiments of a method and/or system for improving fragment assembly and/or sequence identification includes: collecting a sample including a set of nucleic acid components associated with a set of microorganisms; generating a set of tagged sequence fragments; amplifying the set of tagged sequence fragments and sequencing the set of tagged sequence fragments; based upon the set of identifier tags, generating a set of branched assemblies of candidate sequence fragments, wherein each of the set of branched assemblies includes a set of ordered nodes and a set of branches distributed across the set of nodes; implementing a threshold criterion to reduce the set of branched assemblies to a set of branch-reduced assemblies; and identifying a set of sequences corresponding to the set of branch-reduced assemblies and/or generating an analysis informative of the set of microorganisms associated with the sample.

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