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    FMRI-HIPPOCAMPUS ACOUSTIC BATTERY (FHAB)
    111.
    发明公开
    FMRI-HIPPOCAMPUS ACOUSTIC BATTERY (FHAB) 审中-公开

    公开(公告)号：US20230218213A1

    公开(公告)日：2023-07-13

    申请号：US18011068

    申请日：2021-07-01

    申请人： The Johns Hopkins University

    发明人： Una D. McCann

    IPC分类号： A61B5/16 ,  A61B5/00 ,  A61M21/00

    CPC分类号： A61B5/165 ,  A61B5/4064 ,  A61M21/00 ,  A61M2021/0027

    摘要： The present disclosure relates to materials and methods for evaluating acoustic startle response (ASR) and pre-pulse inhibition (PPI) in a subject. In particular, the present disclosure relates to a set of acoustic signals and their use in methods for evaluation and/or treatment of mental disorder in a subject. The methods comprise delivering a set of acoustic signals as described herein to the subject, and measuring the startle response in the subject. The startle response may be the blink reflex, pupil dilation, skin conductive response, and/or brain activity in fMRI. For example, measuring the blink reflex may involve measuring the speed, magnitude, and/or duration of the blink reflex in the subject.

    Stacked-plate distillation column
    112.
    发明授权
    Stacked-plate distillation column 有权

    公开(公告)号：US11691090B2

    公开(公告)日：2023-07-04

    申请号：US17465971

    申请日：2021-09-03

    申请人： The Johns Hopkins University

    发明人： Phillip I. Johnson ,  Jonathan P. Jones

    IPC分类号： B01D3/26 ,  B01D5/00 ,  B01D3/02 ,  B01D3/32

    CPC分类号： B01D5/0015 ,  B01D3/02 ,  B01D3/26 ,  B01D3/324 ,  B01D5/006 ,  B01D5/009

    摘要： A distillation column including a plurality of alternating plates and spacers stacked in a z-direction is provided. The plates include a respective liquid channeling network on a top surface thereof, a respective vapor opening, and a respective descending ramp. The respective descending ramps abut a respective liquid feed location of the plate immediately below to form a continuous liquid channeling network. The respective vapor openings of adjacent plates are located on opposite sides of the distillation column and form a continuous S-shaped vapor channel defined by the plurality of alternating plates and spacers, and the respective vapor openings. Systems including such distillation columns and processes of distilling a fluid mixture are also provided.

    SYSTEM AND METHOD FOR IMPLANTABLE MUSCLE INTERFACE
    117.
    发明公开
    SYSTEM AND METHOD FOR IMPLANTABLE MUSCLE INTERFACE 审中-公开

    公开(公告)号：US20230181340A1

    公开(公告)日：2023-06-15

    申请号：US17926507

    申请日：2021-05-25

    申请人： The Johns Hopkins University

    发明人： Connor Glass ,  Nitish V. Thakor ,  Sami Tuffaha ,  Alexis Lowe

    IPC分类号： A61F2/72 ,  A61B5/389 ,  A61B5/313 ,  A61B5/00

    CPC分类号： A61F2/72 ,  A61B5/389 ,  A61B5/313 ,  A61B5/0031 ,  A61F2002/705

    摘要： An implantable human-machine interfacing system is disclosed that includes an implantable muscle interface device including a substrate including a first plurality of sensors and a second plurality of amplifiers that capture and amplify, respectively, electromyographic (EMG) signals arising from motor units under control of neural signals representative of volitional limb movements; and a transceiver device connected to the first plurality of sensors that wirelessly transmits signals to an external decoder that produces decoded signals that discriminate motor signals representative of movements of the motor units, wherein the substrate at least partially surrounds a muscle from which the EMG signals arise; and a receiver device that uses the decoded signals for interaction with an external system. The system includes a first plurality of electrodes and a second implantable power source that imparts electrical stimulation to the underlying tissues and sensory axons within for the purposes of sensory feedback and neuromodulation.