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    USE OF AMINOSALICYLATES IN DIARRHOEA-PREDOMINENT IRRITABLE BOWEL SYNDROME
    112.
    发明申请
    USE OF AMINOSALICYLATES IN DIARRHOEA-PREDOMINENT IRRITABLE BOWEL SYNDROME 审中-公开
    氨基酸酯在二氧化碳可预防的贝氏综合征中的应用

    公开(公告)号：US20130231308A1

    公开(公告)日：2013-09-05

    申请号：US13742837

    申请日：2013-01-16

    申请人： Nicolas Peter Shortis

    发明人： Nicolas Peter Shortis

    IPC分类号： A61K31/655 ,  A61K45/06 ,  A61K31/606

    CPC分类号： A61K31/655 ,  A61K31/166 ,  A61K31/437 ,  A61K31/606 ,  A61K31/635 ,  A61K45/06 ,  A61K2300/00

    摘要： A method for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-predominant irritable bowel syndrome or other non-specific bowel disorder is disclosed comprising administering to a patient in need of such treatment or prophylaxis an effective amount of balsalazide, or a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or a derivative thereof, or a composition comprising balsalazide the modified compound, or a salt or a derivative thereof together with a suitable carrier. Use of balsalazide, a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or derivative thereof, for the manufacture of a medicament for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-predominant Irritable Bowel Syndrome or other non-specific bowel disorder is also disclosed.

    摘要翻译： 公开了一种治疗或预​​防非炎症性肠病，腹泻型肠易激综合征或其他非特异性肠病的方法，其包括向需要这种治疗或预​​防有效量的巴拉西平或4 -ASA或5-ASA化合物，其包括4-ABA侧链或其盐或衍生物，或包含改性化合物或其盐或衍生物的巴柳氮酯的组合物以及合适的载体。 使用改性的4-ASA或5-ASA化合物的巴柳氮，包括4-ABA侧链或其盐或衍生物，用于制备用于治疗或预防非炎性肠病的药物， 主要肠易激综合征或其他非特异性肠病也被公开。

    MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS
    114.
    发明申请
    MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS 审中-公开
    用于治疗与氧化应激相关的疾病的材料和方法

    公开(公告)号：US20120322773A1

    公开(公告)日：2012-12-20

    申请号：US13477798

    申请日：2012-05-22

    申请人： Jay Pravda

    发明人： Jay Pravda

    IPC分类号： A61K31/606 ,  A61P1/04

    CPC分类号： A61K31/353 ,  A61K31/12 ,  A61K31/19 ,  A61K31/35 ,  A61K31/355 ,  A61K31/381 ,  A61K31/522 ,  A61K31/606 ,  A61K33/04 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    摘要： The subject invention pertains to materials and methods for the prevention and treatment of disease conditions associated with oxidative stress or a compromised reducing environment, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Therapeutic compositions of the invention include compositions that can neutralize hydrogen peroxide, such as reducing agents and oxidizing agents. In one embodiment, a composition includes dihydrolipoic acid as a first reducing agent, an aminosalicylic acid, and a mast cell stabilizer. In another embodiment, the composition further includes a second reducing agent. Methods of the invention include administration of compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient.

    摘要翻译： 本发明涉及用于预防和治疗与氧化应激相关的疾病状况或受损的还原环境（包括诸如克罗恩病和溃疡性结肠炎等炎症性肠病）的材料和方法。 本发明的治疗组合物包括可以中和过氧化氢的组合物，例如还原剂和氧化剂。 在一个实施方案中，组合物包括作为第一还原剂的二氢硫辛酸，氨基水杨酸和肥大细胞稳定剂。 在另一个实施方案中，组合物还包含第二还原剂。 本发明的方法包括施用本发明的化合物或组合物。 在一个实施方案中，将本发明的化合物或组合物直接滴注到患者体内。