公开(公告)号：US10583222B2

公开(公告)日：2020-03-10

申请号：US15380410

申请日：2016-12-15

申请人： UNIVERSITE PAUL SABATIER TOULOUSE III ,  Centre national de la recherche scientifique

发明人： Sophie Cazalbou

IPC分类号： A61L27/02 ,  A61L27/14 ,  A61L27/46 ,  A61L27/34 ,  A61B17/88 ,  A61C8/02 ,  A61F2/28 ,  A61L27/20 ,  A61L27/26 ,  A61L27/32 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C08J9/00 ,  C08J9/30

摘要： The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

公开(公告)号：US20200072721A1

公开(公告)日：2020-03-05

申请号：US16466364

申请日：2017-12-07

申请人： Nestlé Skin Health SA

发明人： Morgan Karlsson ,  Åke Öhrlund

IPC分类号： G01N11/16 ,  A61L27/20 ,  A61L27/52 ,  A61L27/58

摘要： A process for evaluating rheological characteristics of an injectable gel including measuring the flexibility, wherein the flexibility is evaluated by measuring the strain at the crossover point of the amplitude sweep. The process may include subjecting an injectable gel to oscillating mechanical stresses to determine G′ and G″ as a function of strain (γ) in an amplitude sweep, determining the crossover point as the point at which G′ and G″ have the same value, determining the strain γcross at the crossover point, and determining the flexibility of the injectable gel as γcross or proportional to γcross. Further, a method of comparison of dermal fillers by measuring their flexibility and a method of evaluation of dermal filler behavior in human skin by measuring the flexibility.

公开(公告)号：US10580262B2

公开(公告)日：2020-03-03

申请号：US15813917

申请日：2017-11-15

申请人： The General Hospital Corporation

发明人： Mark C. Poznansky ,  Tao Chen

IPC分类号： G07F17/32 ,  A63F1/00 ,  A63F1/06 ,  A61K35/39 ,  A61K9/50 ,  A61L27/20 ,  A61L27/38 ,  C08L5/04 ,  C08B37/00 ,  C09D105/04 ,  A61K38/19 ,  A61K9/70 ,  A61K38/13 ,  A61K38/28 ,  A61K35/12

摘要： CXCL12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.

公开(公告)号：US20200061247A1

公开(公告)日：2020-02-27

申请号：US16612677

申请日：2018-05-16

申请人： T.C ISTANBUL MEDIPOL ÜNIVERSITESI ,  T.C. MARMARA UNIVERSITESI

发明人： Oguzhan GUNDUZ ,  Ahmet Zeki SENGIL ,  Faik Nuzhet OKTAR ,  Nazmi EKREN ,  Selami CAKMAK ,  Ahmet Talat INAN ,  Mehmet Onur AYDOGDU ,  Esra ALTUN

IPC分类号： A61L27/50 ,  A61L27/20 ,  A61L27/24 ,  A61L27/18 ,  A61L27/26 ,  D01D1/02 ,  D01D5/00 ,  D01F2/24

摘要： A three-dimensional biomimetic artificial blood vessel that is biodegradable and biocompatible, is inspired by the morphological structure and physiological role of blood vessels having small diameter in the human circulatory system. A method of production by electro spinning is also disclosed.

公开(公告)号：US10556217B2

公开(公告)日：2020-02-11

申请号：US15941745

申请日：2018-03-30

申请人： THE SECANT GROUP, LLC

发明人： Steven Lu ,  Peter D. Gabriele ,  Julia Donnelly ,  Brian Ginn ,  Charles Brendan Nicholson ,  Jeremy J. Harris ,  Michael S. Flemmens

IPC分类号： B01J13/08 ,  A61L27/54 ,  A61L27/18 ,  A61L27/26 ,  A61L24/00 ,  A61L24/04 ,  C09J133/06 ,  A61L31/04 ,  A61L27/14 ,  A61L27/56 ,  A61L27/20 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L15/22 ,  C09J123/20 ,  A61L27/58 ,  C08J9/24

摘要： A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.

公开(公告)号：US20200038551A1

公开(公告)日：2020-02-06

申请号：US16339527

申请日：2017-10-03

申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY

发明人： Abhay PANDIT ,  Isma Liza MOHD ISA

IPC分类号： A61L27/20 ,  A61L27/52 ,  A61L27/54

摘要： A hydrogel composition for use in a method of regeneration of an intervertebral disc, or suppression of discogenic pain, in a mammal with intervertebral disc degeneration isdescribed. The hydrogel composition comprises cross-linked high molecular weight hyaluronan. The hydrogel composition is implanted in the mammal at a site of intervertebral disc degeneration.

公开(公告)号：US20200030494A1

公开(公告)日：2020-01-30

申请号：US16593941

申请日：2019-10-04

申请人： NESTLÉ SKIN HEALTH S.A.

发明人： Bengt ÅGERUP

IPC分类号： A61L27/50 ,  A61L15/20 ,  A61L15/52 ,  A61L15/58 ,  A61L27/20

摘要： Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.

公开(公告)号：US20200016295A1

公开(公告)日：2020-01-16

申请号：US16508343

申请日：2019-07-11

申请人： LIFEBOND, LTD.

发明人： Guy TOMER ,  Aurelie BENADDI ,  Mary HAINRICHSON ,  Moriah ANOUCHI ,  Amir HADID ,  Ofer YATZIV

IPC分类号： A61L27/22 ,  A61L27/18 ,  A61L27/26 ,  A61L27/54 ,  A61L27/24 ,  A61L27/20 ,  A61L27/56 ,  A61L27/58

摘要： An injectable scaffold made from biocompatible materials. The biocompatible materials comprise a biopolymer, a porogen and a cross-linking agent. The biopolymer may optionally comprise a polypeptide or a polysaccharide.

公开(公告)号：US10525163B2

公开(公告)日：2020-01-07

申请号：US15316403

申请日：2015-06-05

申请人： Josephine Wong

发明人： Josephine Wong ,  Robert Brown

IPC分类号： A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38

摘要： This invention relates to methods of producing collagen biomaterials by admixing (i) a solution of monomeric collagen, (ii) a solution of polymeric collagen, (ii) cargo particles, and (iv) a non-collagen blocking polymer, to produce a collagen solution. The collagen solution is then allowed to solidify to produce a collagen hydrogel. This may be useful in improving the stiffness of collagen hydrogel constructs and increasing the entrapment and retention of cargo particles.

公开(公告)号：US20190351106A1

公开(公告)日：2019-11-21

申请号：US16528593

申请日：2019-07-31

申请人： Cornell Research Foundation, Inc.

发明人： Lawrence BONASSAR ,  Hod LIPSON ,  Daniel L. COHEN ,  Evan MALONE

IPC分类号： A61L27/52 ,  B33Y40/00 ,  A61L27/38 ,  B33Y30/00 ,  B29C64/386 ,  B29C64/106 ,  B33Y50/00 ,  A61L27/36 ,  B33Y10/00 ,  A61L27/20 ,  A61L27/44 ,  A61L27/54 ,  B33Y70/00 ,  B33Y50/02

摘要： The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.