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1.发明申请公开(公告)号：US20220136137A1
公开(公告)日：2022-05-05
申请号：US17452891
申请日：2021-10-29
发明人： Mevlut Tascan , Sengul Teke , Todd Crumbling , Carissa Smoot , Stephanie Reed , Brian Ginn
摘要： A manufacturing process includes combining a liquid resin with a liquid reactive cross-linking composition to form a reactive core composition. The manufacturing also includes contacting the reactive core composition with a sheath composition including a carrier polymer in a solvent. The manufacturing process further includes wet spinning the reactive core composition with the sheath composition to form a sheath-core fiber including a core including at least one continuous fiber of a reaction product of the liquid resin and liquid cross-linking composition and a sheath surrounding the core. The cross-linking composition reacts with the resin during the wet spinning. The sheath includes the carrier polymer. A continuous poly(glycerol sebacate) urethane (PGSU) fiber comprising PGSU and a continuous PGSU fiber forming system are also disclosed.
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公开(公告)号：US10918729B2
公开(公告)日：2021-02-16
申请号：US16263064
申请日：2019-01-31
IPC分类号： A61L27/18 , A61K47/59 , A61K47/34 , A61L24/06 , C08K3/013 , C08G63/12 , C08J3/12 , A61P19/00 , C08L67/00 , A61L27/48 , A61L27/56
摘要： A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.
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公开(公告)号：US11866523B2
公开(公告)日：2024-01-09
申请号：US17223722
申请日：2021-04-06
CPC分类号： C08F2/10 , C08F2/50 , C08F120/14 , C08F2438/02 , C08G63/20 , C08G63/78 , C08G63/916
摘要： A water-mediated process prepares a polymeric (meth)acrylation composition. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a polyol monomer in a vessel under an inert atmosphere and adding a diacid monomer to the vessel under the inert atmosphere. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a copolymer of a polyol monomer and a diacid monomer in a vessel under an inert atmosphere. The process further includes heating and removing water from the vessel under the inert atmosphere to produce the polymeric (meth)acrylation composition. The polymeric (meth)acrylation composition includes a (meth)acrylation polyester copolymer of the diacid monomer and the polyol monomer with the (meth)acrylation component conjugated to the (meth)acrylation polyester copolymer. In some embodiments, the polymeric (meth)acrylation composition is free of mineral acid and free of cytotoxic solvents, catalysts, and scavengers.
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公开(公告)号：US20230125499A1
公开(公告)日：2023-04-27
申请号：US18049519
申请日：2022-10-25
IPC分类号： A61K9/51 , A61K47/34 , C08F120/60 , A61K9/50 , B82Y5/00
摘要： A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.
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5.发明授权公开(公告)号：US11602721B2
公开(公告)日：2023-03-14
申请号：US16735251
申请日：2020-01-06
发明人： Steven Lu , Peter D. Gabriele , Julia Donnelly , Brian Ginn , Charles Brendan Nicholson , Jeremy J. Harris , Michael S. Flemmens
IPC分类号： B01J13/08 , A61L27/56 , A61L27/54 , A61L27/18 , A61L27/20 , A61L27/26 , A61L15/42 , A61L15/44 , A61L15/64 , A61L15/22 , C09J133/06 , C09J123/20 , A61L27/58 , C08J9/24 , A61L31/04 , A61L27/14 , A61L24/00 , A61L24/04
摘要： A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.
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6.发明授权公开(公告)号：US11124762B2
公开(公告)日：2021-09-21
申请号：US16250690
申请日：2019-01-17
IPC分类号： C12N5/00 , A61L27/18 , C08G63/685 , C08K5/17 , C08G63/91 , A61L27/50 , C08K3/32 , C08K3/26 , A61L27/58 , C08L67/00 , A61L27/38
摘要： A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).
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7.发明公开公开(公告)号：US20240254298A1
公开(公告)日：2024-08-01
申请号：US18597423
申请日：2024-03-06
CPC分类号： C08J7/12 , B05D3/101 , B05D7/04 , C08J7/0427 , C12M23/14 , C12M23/28 , B05D2201/02 , B05D2350/30 , B05D2508/00 , C08J2331/04 , C08J2467/00
摘要： In some embodiments, a polymer film includes a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. In some embodiments, a polymer film includes a base layer of a first composition of poly(ethylene-vinyl acetate), a surface layer at a surface of the base layer, and a coating layer of a second composition of a copolymer of glycerol and sebacic acid. The surface layer includes surface hydroxy groups converted from acetate groups of the poly(ethylene-vinyl acetate). The second composition is attached to the surface layer by ester bonds between carboxyl groups of the copolymer and the hydroxy groups. A single-use bioreactor bag includes a polymer film including a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. A method of modifying a poly(ethylene-vinyl acetate) film includes converting acetate groups at a first surface of the poly(ethylene-vinyl acetate) film to hydroxy groups.
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公开(公告)号：US11939444B2
公开(公告)日：2024-03-26
申请号：US17226718
申请日：2021-04-09
CPC分类号： C08J7/12 , B05D3/101 , B05D7/04 , C08J7/0427 , C12M23/14 , C12M23/28 , B05D2201/02 , B05D2350/30 , B05D2508/00 , C08J2331/04 , C08J2467/00
摘要： In some embodiments, a polymer film includes a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. In some embodiments, a polymer film includes a base layer of a first composition of poly(ethylene-vinyl acetate), a surface layer at a surface of the base layer, and a coating layer of a second composition of a copolymer of glycerol and sebacic acid. The surface layer includes surface hydroxy groups converted from acetate groups of the poly(ethylene-vinyl acetate). The second composition is attached to the surface layer by ester bonds between carboxyl groups of the copolymer and the hydroxy groups. A single-use bioreactor bag includes a polymer film including a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. A method of modifying a poly(ethylene-vinyl acetate) film includes converting acetate groups at a first surface of the poly(ethylene-vinyl acetate) film to hydroxy groups.
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9.发明授权公开(公告)号：US10556217B2
公开(公告)日：2020-02-11
申请号：US15941745
申请日：2018-03-30
发明人： Steven Lu , Peter D. Gabriele , Julia Donnelly , Brian Ginn , Charles Brendan Nicholson , Jeremy J. Harris , Michael S. Flemmens
IPC分类号： B01J13/08 , A61L27/54 , A61L27/18 , A61L27/26 , A61L24/00 , A61L24/04 , C09J133/06 , A61L31/04 , A61L27/14 , A61L27/56 , A61L27/20 , A61L15/42 , A61L15/44 , A61L15/64 , A61L15/22 , C09J123/20 , A61L27/58 , C08J9/24
摘要： A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.
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