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公开(公告)号：US09492295B2
公开(公告)日：2016-11-15
申请号：US14985141
申请日：2015-12-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti
CPC classification number: A61F2/91 , A23G9/283 , A61F2240/001 , A61F2250/0068 , B05D1/18 , B05D3/0486 , B05D3/0493 , B05D7/22
Abstract: An apparatus for loading material into a stent strut can comprise a cover sleeve. The cover sleeve is elastic so that it can reduce in diameter so as to press against the stent strut, and expand in diameter so as to be spaced apart from the stent strut. The stent strut can include a lumen into which material is injected. When pressed against the stent strut, the cover sleeve seals side openings to the lumen and prevents injected material from leaking out of the side openings during the injection process.
Abstract translation: 用于将材料装载到支架支柱中的装置可以包括盖套筒。 盖套是弹性的，使得其可以减小直径以便压靠支架支柱，并且直径扩大以与支架支柱间隔开。 支架支架可以包括注射材料的内腔。 当压靠支架支柱时，盖套筒将侧开口密封到内腔，并防止在注射过程中注入材料从侧开口泄漏出来。
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公开(公告)号：US09492294B2
公开(公告)日：2016-11-15
申请号：US14034953
申请日：2013-09-24
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti
CPC classification number: A61F2/90 , A61F2/915 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2240/001 , A61F2250/0068 , B33Y80/00
Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts and links that form a tubular structure. The struts and links can have luminal surfaces facing radially inward, abluminal surfaces facing radially outward, and side surfaces connecting the luminal surfaces to the abluminal surfaces. At least some of the struts and links have through-holes in the side surfaces. At least some of the through-holes contain a drug, which can be carried in a polymer matrix.
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123.发明授权Methods of treatment with a bioresorbable scaffold for neurologic drug delivery 有权用生物可吸收支架治疗神经系统药物递送的方法公开(公告)号：US09486559B2
公开(公告)日：2016-11-08
申请号：US13889259
申请日：2013-05-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Terry B. Mazer , Stephen D. Pacetti , Brenna H. Lord
CPC classification number: A61L31/148 , A61L31/06 , A61L31/146 , A61L31/16 , A61L33/0011 , A61L33/0047 , A61L2300/254 , A61L2300/256 , A61L2300/416 , A61L2300/45 , A61L2300/604 , C08L67/04
Abstract: Bioresorbable scaffolds and methods of treatment with such scaffolds for neurologic disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, and brain neoplasms are disclosed. The bioresorbable scaffold includes a bioresorbable body and an active agent or drug associated with the body for treating or ameliorating the neurological disorder. The bioresorbable scaffold is implanted in the neurological vasculature brain or brain tissue to provide localized delivery of the drug or active agent. Embodiments of the invention include scaffolds that are partially bioresorbable or completely bioresorbable.
Abstract translation: 公开了生物可吸收支架和用这种支架治疗包括帕金森病，亨廷顿病，阿尔茨海默氏病和脑肿瘤的神经障碍的方法。 生物可吸收支架包括生物可吸收体和与身体相关联的用于治疗或改善神经障碍的活性剂或药物。 将生物可吸收的支架植入神经系统的脉管系统脑或脑组织中以提供药物或活性剂的局部递送。 本发明的实施方案包括部分生物可再吸收或完全生物可再吸收的支架。
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公开(公告)号：US20160287420A1
公开(公告)日：2016-10-06
申请号：US15180655
申请日：2016-06-13
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Michael Bialas , John E. Papp , John Simpson , Wouter Erik Roorda , Matt Gillick , Michael L. Green , David P. Strauss , Duane M. DeMore , Robert P. Barbier , Marc Gianotti
CPC classification number: A61F2/966 , A61F2/958 , A61F2/962 , A61F2002/011 , A61F2002/9522 , A61F2002/9583 , A61M25/09 , A61M25/10184 , A61M25/10185 , A61M2025/0183
Abstract: Catheter for delivery of a medical device such as a stent or filter includes an inner tubular member and an outer tubular member movable relative to the inner tubular member. The outer tubular member is disposed at the distal end of the inner tubular member. The inner tubular member includes a fluid lumen defined therein, the fluid lumen having a fluid flow port directed to the exterior surface of the inner tubular member. A pressure chamber is defined by the inner tubular member, the outer tubular member, a proximal seal and a distal seal, and is in fluid communication with the fluid flow port, wherein fluid introduced through the fluid flow port and into the pressure chamber applies a force on the proximal seal to move the outer tubular member in a proximal direction allowing the medical device constrained by the outer tubular member to be released.
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公开(公告)号：US09452138B2
公开(公告)日：2016-09-27
申请号：US14142651
申请日：2013-12-27
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , John Stankus , James Su , Syed Hossainy , Joshua Takeshi Smith , Shadid Askar
IPC: A61K38/00 , A61K9/14 , A61K9/00 , A61K47/10 , A61K9/08 , C07K16/24 , C07K16/40 , A61K38/21 , A61K39/00
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/215 , A61K47/10 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/21
Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。
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Patent Agency Ranking
公开(公告)号：US09452067B2
公开(公告)日：2016-09-27
申请号：US14584431
申请日：2014-12-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Patrick P. Wu
CPC classification number: A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2240/00 , A61F2250/0098 , A61M25/0012 , Y10T29/49826 , Y10T29/49908 , Y10T29/49913 , Y10T29/49927 , Y10T29/49945 , Y10T29/53 , Y10T29/53548
Abstract: A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.
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公开(公告)号：US20160263291A1
公开(公告)日：2016-09-15
申请号：US15160999
申请日：2016-05-20
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： O. Mikael TROLLSAS , Michael H. NGO , David J. SHERMAN , Syed F.A, HOSSAINY
CPC classification number: A61L31/10 , A61K9/5031 , A61K9/5089 , A61K31/33 , A61K31/436 , A61K31/497 , A61K31/56 , A61K38/13 , A61K38/446 , A61K45/06 , A61K47/34 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02 , C08L71/02 , C08L67/04
Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
Abstract translation: 本发明提供具有包含缓慢溶解性聚合物或材料的涂层的可植入装置及其制造和使用方法。
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公开(公告)号：US09439869B2
公开(公告)日：2016-09-13
申请号：US14086907
申请日：2013-11-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian N. Ludwig , Stephen D. Pacetti , Syed F. A. Hossainy , Dariush Davalian
IPC: A61K9/50 , A61K9/51 , A61K38/44 , A61K41/00 , A61K47/48 , A61L31/16 , B01J13/02 , B22F1/02 , B82Y5/00 , A61K9/00
CPC classification number: A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
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129.发明授权公开(公告)号：US09439792B2
公开(公告)日：2016-09-13
申请号：US14053019
申请日：2013-10-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Cameron K. Kerrigan
CPC classification number: A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61F2250/0068 , B33Y80/00 , Y10T29/49826
Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.
Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。
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公开(公告)号：US20160228269A1
公开(公告)日：2016-08-11
申请号：US15135230
申请日：2016-04-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Ainsworth , Andreina P. Gomez
CPC classification number: A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/9155 , A61F2002/91575 , A61F2230/0054
Abstract: The invention provides an improved stent design for repairing vasculature, the stent having rings including struts defining first peaks and second peaks, selected second peaks of adjacent rings being connected by links. The stent design incorporates non-linear links with undulating portions extending generally perpendicular to or circumferentially with respect to a longitudinal axis of the stent and adjacent first peaks with different longitudinal lengths such that stent flexibility is increased without sacrificing stent compression for delivery.
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