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公开(公告)号：US11306095B2
公开(公告)日：2022-04-19
申请号：US15577518
申请日：2016-05-30
Inventor： Honglin Li , Yufang Xu , Zhenjiang Zhao , Wei Zhou , Yuqiong Xu , Deheng Sun , Xia Wang , Zhuo Chen
IPC: C07D487/04 , A61P35/00 , A61P35/02 , A61K31/519 , C07D475/00
Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
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公开(公告)号：US11291200B2
公开(公告)日：2022-04-05
申请号：US16347429
申请日：2017-11-22
Inventor： Meijin Guo , Jiarui Li , Zejian Wang , Yuxia Chen , Yingping Zhuang
Abstract: The present disclosure relates to the application of a viable cell monitor to the cryopreservation of plant cells. The viable cell monitor is, for the first time, used in a method for rapidly evaluating the effect of cell freezing-preservation. The effect of a cryoprotectant on cell preservation is evaluated through the change in the capacitance of viable cells before and after cell freezing and resuscitation. Viable cell electrodes can provide a quick and accurate characterization of viable cell concentrations. Combining the viable cell capacitance with the detection result of 2,3,4-triphenyl tetrazolium chloride (TTC), a rapid and quantitative evaluation of the effect of a freezing method on cell preservation can be achieved, thus overcoming the low effectiveness and non-quantification of previous cell preservation methods. Compared with traditional methods, the method of the present disclosure can improve the comprehensive score of cell cryopreservation by 5 times or more.
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123.发明申请公开(公告)号：US20220057194A1
公开(公告)日：2022-02-24
申请号：US17312543
申请日：2019-03-28
Inventor： Xiancheng Zhang , Shuang Liu , Shulei Yao , Xumin Zhu , Kaiming Zhang , Yixin Liu , Yunfei Jia , Shantung Tu
Abstract: The present application provides an on-machine point cloud detection and compensation method for processing complex surfaces, which comprises: step S1, installing a detecting and scanning actuator on an ultrasonic rolling machine tool; step S2, installing a processed workpiece on the chuck which is scanned by the detecting and scanning actuator to obtain the point cloud data of the workpiece in a coordinate system of detecting and scanning actuator, which is converted into the point cloud data of the workpiece in a coordinate system of machine tool; step S3, processing the point cloud data of the workpiece in the coordinate system of machine tool; step S4, obtaining and compensating the shape error feature of the workpiece according to theoretical design data of the processed workpiece and processed point cloud data of the workpiece in the coordinate system of machine tool. The accuracy and efficiency of complex surface strengthening is improved in the present application.
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公开(公告)号：US20220002684A1
公开(公告)日：2022-01-06
申请号：US17294424
申请日：2019-11-26
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
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公开(公告)号：US20210179598A1
公开(公告)日：2021-06-17
申请号：US17046996
申请日：2019-04-12
Inventor： Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU
IPC: C07D413/10 , C07D401/14 , C07D405/14 , C07D213/73 , C07D401/04 , C07D401/10 , C07D487/04 , C07D471/04 , C07D401/12 , C07D417/04
Abstract: Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.
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Patent Agency Ranking
126.发明申请公开(公告)号：US20200165530A1
公开(公告)日：2020-05-28
申请号：US16665233
申请日：2019-10-28
Inventor： Zhishan Bai , Yan Zhang , Xiaoyong Yang , Huiqing Luo
Abstract: The present disclosure relates to a method and an apparatus for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product. There is provided a method for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product. One step is to coalesce and vaporize a preliminarily distributed sulfuric acid alkylation reaction product to cause preliminary vaporization of a hydrocarbon therein, thereby taking heat away and preliminarily separating the hydrocarbon from sulfuric acid. Another step is to subject the preliminarily separated alkylation reaction to reinforced separation, where the hydrocarbon is further vaporized to take heat away and further separate the hydrocarbon from the sulfuric acid. There is also provided an apparatus for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product.
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127.发明授权公开(公告)号：US10598585B2
公开(公告)日：2020-03-24
申请号：US15324552
申请日：2015-06-15
Inventor： Hualin Wang , Yuan Huang , Yang Qiu , Pengbo Fu , Yanhong Zhang , Zhishan Bai , Qiang Yang , Fengqin He
Abstract: A method and a device for synchronous high-speed photographing of microparticle rotation in a liquid cyclone field and for determining the rotation velocity of a microparticle in a liquid cyclone field by using a combination of a synchronous high-speed photographing system and a transparent microparticle containing two centrosymmetrically arranged inner cores having the same diameter. The method comprises: using a transparent microparticle comprising two inner cores having the same diameter and arranged centrosymmetrically as a rotation test particle; acquiring synchronously two groups of two dimensional image series of microparticle motion in a liquid cyclone field using two orthogonally arranged high-speed digital cameras; and reconstructing a three dimensional motion trajectory of the microparticle from the two groups of synchronous image series, and determining a rotation velocity of the microparticle in the cyclone field at the same time.
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公开(公告)号：US10301516B2
公开(公告)日：2019-05-28
申请号：US15327920
申请日：2015-07-20
Applicant: KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD. , SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Zhelong Li , Wanyu Zhu , Heji Lei , Fangqun Wu , Zuoxiang Zeng
IPC: C09J167/02 , C09J11/06 , C08G63/672
Abstract: A method for preparation of a high-viscosity polyester hot-melt adhesive with a partially sensitive viscosity-temperature property is disclosed, including the steps of: i) subjecting terephthalic acid, isophthalic acid, dodecanedioic acid, adipic acid, butanediol, dipropylene glycol and hexanediol to an esterification reaction in the presence of tetrabutyl titanate serving as a catalyst; and ii) adding an antioxidant to a product resulting from step i) to conduct a polycondensation reaction under a reduced pressure so as to obtain the high-viscosity polyester hot-melt adhesive which has a low melting point of 130° C.-135° C. and a partially sensitive viscosity-temperature property.
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公开(公告)号：US20190134008A1
公开(公告)日：2019-05-09
申请号：US16306465
申请日：2017-06-02
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUT OF PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Inventor： Ke XU , Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU , Wenlin SONG , Yi TONG
IPC: A61K31/426 , A61P31/12
Abstract: Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:
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公开(公告)号：US10203536B2
公开(公告)日：2019-02-12
申请号：US15316429
申请日：2014-06-05
Inventor： Zhigang Zheng
IPC: C09K19/00 , G02F1/1333 , C09K19/52 , C09K19/54 , C09K19/58 , C09K19/60 , G02F1/137 , C09B31/12 , C09K11/06 , G02F1/1334
Abstract: A photo-tunable liquid crystal composition may include a polymer matrix and a liquid crystal mixture dispersed within the polymer matrix. The liquid crystal mixture may include at least one achiral nematic liquid crystal material, at least sine photo-active chiral dopant, at least one photo-inactive chiral dopant, and at least one emissive dye. The composition may be fabricated in the form of an emulsion, a wet film, or a dry film. The dry film may be used in a photo-tunable liquid crystal film laser. The output wavelength of the photo-tunable liquid crystal film laser may be tuned by exposing the dry film to illumination having at least one wavelength at one or more transition wavelengths.
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