公开(公告)号：US11746396B2

公开(公告)日：2023-09-05

申请号：US16767792

申请日：2018-12-03

Applicant: MONASH UNIVERSITY

Inventor： Paul Rometsch ,  Xinhua Wu ,  Qingbo Jia

IPC: C22C1/04 ,  B33Y70/00 ,  B22F3/24 ,  C22C21/00 ,  C22F1/00 ,  C22F1/04 ,  B22F10/28 ,  B22F12/20 ,  B22F10/64

CPC classification number: C22C1/0416 ,  B22F3/24 ,  B22F10/28 ,  B22F10/64 ,  B22F12/20 ,  B33Y70/00 ,  C22C21/00 ,  C22F1/002 ,  C22F1/04 ,  B22F2003/248 ,  B22F2998/10 ,  B22F10/28 ,  B22F3/1028 ,  B22F2003/248

Abstract: An aluminium based alloy, and a method for production of components by additive manufacturing (AM) or other rapid solidification process with the alloy, is based on the alloy having a composition with from 2.01 wt % to 15.0 wt % manganese, from 0.3 wt % to 2.0 wt % scandium, with a balance apart from minor alloy elements and incidental impurities of aluminium.

公开(公告)号：US20230272045A1

公开(公告)日：2023-08-31

申请号：US18001480

申请日：2021-06-11

Applicant: MONASH UNIVERSITY

Inventor： Mikaël MARTINO ,  Ziad JULIER

IPC: C07K14/715 ,  C07K14/475 ,  C12N15/62 ,  A61P17/02 ,  C07K14/71

CPC classification number: C07K14/7155 ,  C07K14/475 ,  C12N15/62 ,  A61P17/02 ,  C07K14/71 ,  C07K2319/33

Abstract: The present invention provides a fusion protein comprising interleukin-1 receptor antagonist (IL-1Ra) and an extracellular matrix (ECM) binding peptide which specifically binds to one or more or all extracellular matrix proteins selected from the group consisting of fibrinogen, fibronectin, vitronectin, tenascin C and heparan sulfate and use of the fusion protein to treat conditions in which administration of IL-1Ra is beneficial or in which IL-1R1 signalling needs to be dampened, to enhance tissue regeneration, particularly bone regeneration and/or wound repair or for treating wounds, burns and muscle, cartilage, tendon and bone disorders, to enhance the regenerative activity of growth factor administration or to reduce inflammation or desensitisation of a cell to growth factor stimulation.

公开(公告)号：US20230216086A1

公开(公告)日：2023-07-06

申请号：US17924827

申请日：2021-05-13

Applicant: DEAKIN UNIVERSITY ,  MONASH UNIVERSITY

Inventor： Jenny PRINGLE ,  Karolina Matuszek ,  Tim Newbegin ,  Faezeh Makhlooghi Azad

IPC: H01M10/0564 ,  H01M10/052 ,  H01M10/054

CPC classification number: H01M10/0564 ,  H01M10/052 ,  H01M10/054 ,  H01M2300/0065

Abstract: The invention provides a zwitterionic plastic crystal (ZIPC) compound in the form of a single molecule comprising: at least one positively charged functional group carrying at least one positive charge, and at least one negatively functional group carrying at least one negative charge, wherein the positively charged functional groups and the negatively charged functional groups are covalently tethered together in the molecule, and the net charge of the zwitterionic compound is zero, and wherein the compound exhibits evidence of molecular disorder in the solid state.

公开(公告)号：US11690938B2

公开(公告)日：2023-07-04

申请号：US16462910

申请日：2017-11-22

Applicant: Alfred Health ,  Monash University

Inventor： Mark Fitzgerald ,  Peter Finnegan ,  Wing Chiu ,  Nayeem Chowdhury ,  Nabil Chowdhury

IPC: A61M1/04 ,  A61B17/34 ,  A61B17/00

CPC classification number: A61M1/04 ,  A61B17/3403 ,  A61B17/3421 ,  A61B17/3462 ,  A61B17/3496 ,  A61B17/3474 ,  A61B2017/00455 ,  A61B2017/3407 ,  A61B2017/349 ,  A61B2017/3427 ,  A61B2017/3443 ,  A61B2017/3488

Abstract: A surgical system for use in establishing and maintaining an opening to an anatomical space of a body, the system comprising an obturator assembly having a cutting portion at a distal end and a cannula, the cannula being detachably coupled to the cutting portion and deployable into the anatomical space of a patient, the cannula comprises a locking portion, and a lengthwise extendable body; a valve assembly comprising a passage for receiving the cannula, a first end for coupling to a fluid extraction device and a second end for placement external and adjacent the anatomical space; a base comprising a plate for placement on a patient external and adjacent the anatomical space, the plate has an aperture configured for receiving the obturator assembly and coupling means located about the aperture for coupling with the valve assembly; and wherein, in use, the locking portion of the cannula is configured to be retained in the valve assembly with the extendable body extended into the anatomical space to facilitate a path for fluid extraction, and wherein the cannula comprises means for retaining the cannula in its extended state.

公开(公告)号：US20230202120A1

公开(公告)日：2023-06-29

申请号：US18111929

申请日：2023-02-21

Applicant: Monash University

Inventor： Marten Jurg ,  Andrey Molotnikov

IPC: B29C64/393 ,  B33Y10/00 ,  B22F10/00 ,  B22F10/28 ,  B22F12/90 ,  B22F10/364 ,  B22F10/366 ,  B22F10/38 ,  B22F10/85

CPC classification number: B29C64/393 ,  B22F10/00 ,  B22F10/28 ,  B22F10/38 ,  B22F10/85 ,  B22F10/364 ,  B22F10/366 ,  B22F12/90 ,  B33Y10/00 ,  B33Y30/00

Abstract: An additive manufacturing system and method is provided for fabricating 3D objects (16) from successive layers (14) of material. The additive manufacturing system (10) has an energy projection assembly (20) for inputting energy (22) into a specified area within the layer (18) to consolidate the material; a plurality of image sensors (30, 32, 34), each of the image sensors having a corresponding field of view (35, 40, 42) covering at least part of the layer (18) of material, such that each of the fields of view at least partially overlap with the field of view of at least one other of the image sensors; and an image processor (56) to capture image data from each of the image sensors (30, 32, 34). The image processor (56) controls exposure times for each of the image sensors (30, 32, 34) and combines the image data from the image sensors to provide a single, spatially resolved image of the energy being input throughout the specified area for each layer (14) of material respectively for comparison against threshold data values to locate potential consolidation defects in the specified area.

公开(公告)号：US20230110966A1

公开(公告)日：2023-04-13

申请号：US17904499

申请日：2021-02-18

Applicant: Hudson Institute of Medical Research ,  Monash University ,  Monash Health

Inventor： Samuel Charles FORSTER ,  Edward Mark GILES ,  Gemma Louise D'ADAMO

IPC: C12Q1/689 ,  C12Q1/6869

Abstract: The present invention generally relates to methods of identifying microorganisms of the microbiome.

公开(公告)号：US20230062834A1

公开(公告)日：2023-03-02

申请号：US16955084

申请日：2018-12-19

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth BONNER ,  Sifei HAN ,  Luojuan HU ,  Ketki KARANAM ,  Christopher John PORTER ,  Tim QUACH ,  Rishab R. SHYAM ,  Jamie SIMPSON ,  Natalie TREVASKIS

IPC: C07D498/18 ,  A61P37/06

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20230015481A1

公开(公告)日：2023-01-19

申请号：US17930364

申请日：2022-09-07

Applicant: MONASH UNIVERSITY ,  MURDOCH UNIVERSITY

Inventor： Stephen WILTON ,  Merlin Christopher THOMAS ,  Carlos ROSADO ,  Raelene Jane PICKERING

IPC: C12N15/113

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

公开(公告)号：US20220411477A1

公开(公告)日：2022-12-29

申请号：US17773529

申请日：2020-10-30

Applicant: MONASH UNIVERSITY

Inventor： Craig Anthony HARRISON ,  Kelly Louise WALTON

IPC: C07K14/575 ,  C12N15/861 ,  A61P35/00 ,  A61P15/18

Abstract: The present disclosure relates to anti-mullerian hormone (AMH) analogues, more particularly AMH analogues which are agonists of the AMH type II receptor (AMHR2). More particularly, the present disclosure relates to AMH analogues having a modification present within one or more of amino acid residues 533 to 548 of SEQ ID NO:1.

公开(公告)号：US20220339168A1

公开(公告)日：2022-10-27

申请号：US17753936

申请日：2020-09-21

Applicant: Monash University

Inventor： Natalie TREVASKIS ,  Christopher John PORTER ,  Tim QUACH ,  Sifei HAN ,  Enyuan CAO ,  Luojuan HU ,  Matthew WATT

IPC: A61K31/635 ,  A61K31/404 ,  A61P3/04

Abstract: The present invention provides methods of treating metabolic diseases including obesity, insulin resistance and type 2 diabetes with inhibitors of COX-2 or VEGFR and lipid prodrugs of COX-2 inhibitors, in particular celecoxib lipid prodrugs, that promote transport of the pharmaceutical agent to the lymphatic system and which enhance release of the parent agent.