公开(公告)号：US10085651B2

公开(公告)日：2018-10-02

申请号：US14383787

申请日：2013-03-13

申请人： The Penn State Research Foundation

发明人： Kim Kopenhaver Doheny ,  Charles Palmer

IPC分类号： A61B5/024 ,  A61B5/08 ,  A61B5/00 ,  G06F19/00 ,  A61B5/0205

摘要： Embodiments are presented herein that provide early prediction of the development of necrotizing enterocolitis by a preterm infant through analysis of the high frequency component of heart rate variability, optionally with analysis of respiration rate. Methods of treatment following prediction area also reported.

公开(公告)号：US20180265906A1

公开(公告)日：2018-09-20

申请号：US15993901

申请日：2018-05-31

申请人： The Penn State Research Foundation

发明人： Stephen J. Benkovic ,  Frank Salinas

IPC分类号： C12P19/34 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6844 ,  C12N15/10

CPC分类号： C12P19/34 ,  C12N15/1027 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q2521/507 ,  C12Q2521/513 ,  C12Q2527/125

摘要： A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

公开(公告)号：US20180230811A1

公开(公告)日：2018-08-16

申请号：US15355173

申请日：2016-11-18

申请人： United Technologies Corporation ,  The Penn State Research Foundation

发明人： Scott D. Lewis ,  Stephen Lynch ,  Shane Haydt

IPC分类号： F01D5/18

CPC分类号： F01D5/186 ,  F05D2230/12 ,  F05D2250/19 ,  F05D2250/312 ,  F05D2250/314 ,  F05D2260/202 ,  Y02T50/676

摘要： A component for a gas turbine engine including a body having at least one internal cooling cavity and a plurality of film cooling holes disposed along a first edge of the body. At least one of the film cooling holes includes a metering section defining an axis, and a diffuser section having a centerline. The centerline of the diffuser section is offset from the axis of the metering section.

公开(公告)号：US20180185456A1

公开(公告)日：2018-07-05

申请号：US15860966

申请日：2018-01-03

申请人： The Penn State Research Foundation

发明人： Gong Chen ,  Zheng Wu

IPC分类号： A61K38/44 ,  A61P25/08

CPC分类号： A61K38/443 ,  A61P25/08 ,  C12Y101/03004

摘要： Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, and the glucose oxidase enzyme, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo. Sodium gluconate is shown to inhibit epileptiform burst activity in cell cultures and protect neurons from kainic acid-induced cell death. Sodium gluconate also inhibited epileptiform burst activity in brain slices in a manner that was much more potent in neonatal animals than in older animals. Consistently, in vivo EEG recordings also revealed that sodium gluconate inhibited the epileptic seizure activity in a manner that was much more potent in neonates than in adult animals. Mechanistically, sodium gluconate inhibits voltage-dependent CLC-3 Cl− channels both in neuronal cultures and in hippocampal slices. Together, these data suggest a novel antiepileptic drug gluconate that potently inhibits neonatal seizures through blocking CLC-3 Cl− channels.

公开(公告)号：US10013477B2

公开(公告)日：2018-07-03

申请号：US15282947

申请日：2016-09-30

申请人： The Penn State Research Foundation

发明人： Jianbo Ye ,  Jia Li ,  James Z. Wang

IPC分类号： G06F17/30 ,  G06N99/00

CPC分类号： G06F16/285 ,  G06N20/00

摘要： Computationally efficient accelerated D2-clustering algorithms are disclosed for clustering discrete distributions under the Wasserstein distance with improved scalability. Three first-order methods include subgradient descent method with re-parametrization, alternating direction method of multipliers (ADMM), and a modified version of Bregman ADMM. The effects of the hyper-parameters on robustness, convergence, and speed of optimization are thoroughly examined. A parallel algorithm for the modified Bregman ADMM method is tested in a multi-core environment with adequate scaling efficiency subject to hundreds of CPUs, demonstrating the effectiveness of AD2-clustering.

公开(公告)号：US20180177904A1

公开(公告)日：2018-06-28

申请号：US15854121

申请日：2017-12-26

申请人： The Penn State Research Foundation

发明人： John J. Janowiak ,  Kelli Hoover

IPC分类号： A61L2/08 ,  B27K5/00

CPC分类号： A61L2/08 ,  B27K5/001 ,  B27K5/0055 ,  B27K2240/20 ,  H05B6/62

摘要： A method for treating wood packaging materials using Radio Frequency heating includes the steps of heating wood packaging materials using RF heating and applying a pressure before the heating or incrementally applying a pressure during the heating until a temperature of the wood packaging materials reaches at least 60° C. and that temperature is maintained for at least 1 minute.

公开(公告)号：US20180155239A1

公开(公告)日：2018-06-07

申请号：US15831930

申请日：2017-12-05

申请人： The Penn State Research Foundation

发明人： Tak-Sing WONG ,  Yu Huang ,  Birgitt Boschitsch ,  Nan Sun

IPC分类号： C03C17/34 ,  C08K7/18 ,  C08K3/08 ,  C03C17/30 ,  C03C17/32

CPC分类号： C03C17/3405 ,  C03C17/30 ,  C03C17/32 ,  C03C17/42 ,  C03C2217/445 ,  C03C2217/48 ,  C03C2217/76 ,  C03C2218/116 ,  C03C2218/322 ,  C08K3/08 ,  C08K7/18 ,  C08K2003/0856 ,  C08K2201/01 ,  C09D5/1675 ,  C09D5/1681 ,  C09D7/69

摘要： A substrate with a switchable surface has been developed that can rapidly switch its surface character such as between two distinct liquid-repellent modes: (1) a superhydrophobic mode and (2) a slippery mode. Such surfaces have demonstrated adaptive liquid repellency and water harvesting capabilities.

公开(公告)号：US09963751B2

公开(公告)日：2018-05-08

申请号：US15355643

申请日：2016-11-18

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： Jianming Hu

IPC分类号： A61K39/00 ,  C07K14/005 ,  C07K14/03 ,  C07K14/125 ,  C07K14/18 ,  C12Q1/70 ,  C12Q1/68

CPC分类号： C12Q1/70 ,  C12Q1/6816 ,  C12Q1/706 ,  C12Q2525/307

摘要： Provided are compositions and methods for identifying test agents as candidate for use in reducing hepatitis B virus (HBV). The methods involve a) introducing at least one test agent into mammalian cells, the cells having one or more plasmids that encode an HBV genome, wherein the genome includes a segment encoding a mutated HBV core (HBc), wherein the HBc mutation is L60A, I126A, K96A or a combination thereof. The test agent is allowed to be in contact with the mammalian cells for a period of time. Subsequently, amounts of HBV cccDNA in the mammalian cells are determined. The method can be performed in vitro or in vivo. A reduction in cccDNA relative to a control indicates the test agent in the test container is a candidate for reducing HBV in an individual. Cell cultures divided into reaction containers that each contain a distinct test agent are also included.

公开(公告)号：US20180117083A1

公开(公告)日：2018-05-03

申请号：US15724998

申请日：2017-10-04

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： Thomas Wood ,  Brian Kwan ,  Nityananda Chowdhury

IPC分类号： A61K33/24 ,  A61K31/407 ,  A61K31/33

CPC分类号： A61K33/24 ,  A61K31/282 ,  A61K31/33 ,  A61K31/40 ,  A61K31/407 ,  A61P31/04 ,  Y02A50/473 ,  A61K2300/00

摘要： The present disclosure provides a method for killing persister cells with mitomycin C and/or cisplatin, or derivatives thereof. Recalcitrant infections are difficult to treat due to persister cells, a subpopulation of all bacterial populations that is highly tolerant against all traditional antibiotics since the cells are dormant and antibiotics are designed to kill growing cells. Here, we show that MMC and cisplatin eradicate persister cells through a growth-independent mechanism, cross-linking DNA. We find both agents are effective against both planktonic cultures and highly robust biofilm cultures for a broad range of bacterial species, including commensal Escherichia coli K-12 as well as pathogenic species of E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In certain approaches cisplatin is superior to MMC.

公开(公告)号：US20180090309A1

公开(公告)日：2018-03-29

申请号：US15712561

申请日：2017-09-22

申请人： The Penn State Research Foundation

发明人： Joshua Alexander Robinson ,  Rafael Vila

IPC分类号： H01L21/02 ,  H01L29/06 ,  H01L29/24

CPC分类号： H01L21/0259 ,  H01L21/02376 ,  H01L21/02378 ,  H01L21/02381 ,  H01L21/0242 ,  H01L21/02565 ,  H01L21/02568 ,  H01L21/02612 ,  H01L21/02664 ,  H01L29/045 ,  H01L29/0665 ,  H01L29/0669 ,  H01L29/24 ,  H01L29/66795 ,  H01L29/778 ,  H01L29/785

摘要： The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated.