公开(公告)号：US20060194282A1

公开(公告)日：2006-08-31

申请号：US11334218

申请日：2006-01-17

申请人： Roger Tsien ,  Robert Campbell ,  Geoffrey Baird

发明人： Roger Tsien ,  Robert Campbell ,  Geoffrey Baird

IPC分类号： C07K14/435 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12Q1/25 ,  C07K14/43595 ,  G01N33/585 ,  G01N33/84 ,  G01N2500/02

摘要： The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomeric structures. The invention also relates to methods of making and using such fluorescent protein monomers and dimers.

摘要翻译： 本发明一般涉及变体荧光蛋白，更具体地涉及Anthozoan荧光蛋白的单体和二聚形式。 在一个方面，本发明提供荧光蛋白的变体，其中变体具有降低的四聚体倾向并形成二聚体或单体结构。 本发明还涉及制备和使用这种荧光蛋白单体和二聚体的方法。

公开(公告)号：US20060171917A1

公开(公告)日：2006-08-03

申请号：US11292659

申请日：2005-12-02

申请人： Robert Campbell ,  Kevin Dolan ,  Wendy Woodley

发明人： Robert Campbell ,  Kevin Dolan ,  Wendy Woodley

IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K48/00 ,  A61K38/19

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/55538 ,  A61K2039/5555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/70 ,  A61M5/46 ,  C12N2760/16134 ,  C12N2760/16234

摘要： The present invention relates to compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more adjuvants. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one adjuvant, which enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention have enhanced efficacy as the adjuvants of the composition promote recruitment of antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention results in a therapeutically and/or prophylactically effective immune response after a single intradermal dose, with lower doses of adjuvant than conventionally used, achieving therapeutic efficacy from a single administration.

摘要翻译： 本发明涉及与一种或多种佐剂组合用于皮内递送抗原或免疫原性试剂的组合物。 本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种佐剂，其一旦被递送到受试者的皮肤的皮内隔室就增强了对抗原或免疫原性试剂的免疫应答。 本发明的免疫原性组合物具有增强的功效，因为组合物的佐剂促进将抗原呈递细胞募集到皮内隔室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。 本发明的免疫原性组合物的增强的功效在单次皮内剂量之后导致治疗和/或预防有效的免疫应答，使用比常规使用的更低剂量的佐剂，从单一给药获得治疗功效。

公开(公告)号：US20050280053A1

公开(公告)日：2005-12-22

申请号：US10873429

申请日：2004-06-22

申请人： Monty Hayes ,  Robert Campbell ,  John Fruth

发明人： Monty Hayes ,  Robert Campbell ,  John Fruth

IPC分类号： H01L29/423 ,  H01L29/739 ,  H01L29/76 ,  H01L29/78

CPC分类号： H01L29/4238 ,  H01L29/7393 ,  H01L29/7802

摘要： A semiconductor device includes a device body, a gate pad and a gate signal distribution runner. The device body includes a plurality of parallel cells and the gate pad is located on a top surface of the device body adjacent a corner of the device body. The gate signal distribution runner includes a peripheral gate signal distribution runner extending around the periphery of the device body from the gate pad and a diagonal gate signal distribution runner extending diagonally across the device body from the gate pad. The gate signal distribution runner provides a gate signal to a gate of each of the plurality of parallel cells.

摘要翻译： 半导体器件包括器件本体，栅极焊盘和栅极信号分配流道。 装置本体包括多个平行单元，并且该栅垫位于与装置主体的角部相邻的装置主体的顶表面上。 门信号分配器包括从栅极焊盘延伸围绕器件本体的周边的外围栅极信号分配器，以及从栅极焊盘横跨器件本体对角线延伸的对角线栅极信号分配器。 门信号分配器向多个并行单元中的每一个的栅极提供栅极信号。

公开(公告)号：US20050219828A1

公开(公告)日：2005-10-06

申请号：US11075539

申请日：2005-03-09

申请人： Steven Willing ,  Kent Carlson ,  Robert Campbell ,  Alberto Avendano

发明人： Steven Willing ,  Kent Carlson ,  Robert Campbell ,  Alberto Avendano

IPC分类号： H02P1/00 ,  H05K1/02 ,  H05K1/14

CPC分类号： H05K1/0263 ,  H05K1/14 ,  H05K2201/09954 ,  H05K2201/2018

摘要： A plastic frame converts a power printed circuit board to an open frame power supply suitable for mounting on stand-offs, comprising versions of this frame with various options to attach input and output connectors and versions with solid plastic bottom to provide electrical isolation beneath the power supply and a ground plane beneath the power supply.

摘要翻译： 塑料框架将电力印刷电路板转换为适合安装在支架上的开放式框架电源，包括该框架的版本，具有各种选项，可以连接输入和输出连接器以及具有固体塑料底部的版本，以提供电源下的电气隔离 供电和电源下面的接地层。

公开(公告)号：US20050186634A1

公开(公告)日：2005-08-25

申请号：US10841049

申请日：2004-05-07

申请人： Perry Haaland ,  Douglas Sherman ,  Robert Campbell ,  Walter Stewart ,  Sheila Lloyd ,  Bruce Erickson ,  Ann Erickson

发明人： Perry Haaland ,  Douglas Sherman ,  Robert Campbell ,  Walter Stewart ,  Sheila Lloyd ,  Bruce Erickson ,  Ann Erickson

IPC分类号： C12P21/02 ,  C07K1/04 ,  C07K5/10 ,  C07K7/04 ,  C07K7/06 ,  C12N1/00 ,  C12R1/145 ,  C40B40/02 ,  C40B50/06 ,  G01N33/53 ,  C12N5/00 ,  C12P21/06

CPC分类号： C07K7/06 ,  C07K1/047 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C40B30/06

摘要： The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.

摘要翻译： 本发明提供了可用于快速鉴定生物活性化合物的肽文库。 本发明还提供了包括增强或抑制细胞蛋白产生的细胞生长影响肽和肽的肽。 本发明的许多肽可以通过重组技术大量生产并配制在培养基中以对培养的细胞和组织产生所需的效果。 本发明的某些文库和其中鉴定的肽在基于连接体的重组表达方法中特别有用。

公开(公告)号：US20050180952A1

公开(公告)日：2005-08-18

申请号：US10868482

申请日：2004-06-14

申请人： Ronald Pettis ,  Alfred Harvey ,  Robert Campbell ,  John Mikszta ,  John Brittingham ,  Glenn Vonk ,  Colleen Nycz

发明人： Ronald Pettis ,  Alfred Harvey ,  Robert Campbell ,  John Mikszta ,  John Brittingham ,  Glenn Vonk ,  Colleen Nycz

IPC分类号： A61K31/496 ,  A61K38/20 ,  A61K38/21 ,  A61K39/395 ,  A61K45/00 ,  A61M20060101 ,  A61M23/00

CPC分类号： A61K9/0021 ,  A61K9/0019

摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents, such as therapeutic agents, through lymphatic vasculature accessed by intradermal delivery. Therapeutic agents to be delivered in accordance with the present invention include, but are not limited to, antineoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenesis agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present invention have improved bioavailability, including improved systemic distribution and improved delivery to particular tissues. Therapeutic agents delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over conventional drug delivery methods including dose sparing, increased drug efficacy, reduced side effects, reduced metastatic potential and prolonged survival.

摘要翻译： 本发明涉及用于将一种或多种生物活性剂，特别是治疗剂递送到受试者皮肤的皮内隔室的方法和装置。 本发明提供通过皮内递送获得的淋巴脉管系统递送生物活性剂如治疗剂的改进方法。 根据本发明要递送的治疗剂包括但不限于抗肿瘤剂，化学治疗剂，抗体，抗生素，抗血管发生剂，抗炎剂和免疫治疗剂。 根据本发明递送的治疗剂具有改善的生物利用度，包括改进的全身分布和改善的递送到特定组织。 根据本发明方法递送的治疗剂相对于其它药物递送方法具有改善的临床效用和治疗功效，包括腹膜内，肌内和皮下递送。 本发明的方法相对于常规药物递送方法提供益处和改进，包括剂量节省，药物功效增加，副作用减少，转移潜力降低和延长生存期。

公开(公告)号：US20050163711A1

公开(公告)日：2005-07-28

申请号：US10867908

申请日：2004-06-14

申请人： Colleen Nycz ,  Glenn Vonk ,  John Brittingham ,  Ronald Pettis ,  Alfred Harvey ,  Robert Campbell ,  John Mikszta ,  Diane Sutter

发明人： Colleen Nycz ,  Glenn Vonk ,  John Brittingham ,  Ronald Pettis ,  Alfred Harvey ,  Robert Campbell ,  John Mikszta ,  Diane Sutter

IPC分类号： A61K49/00 ,  A61M20060101

CPC分类号： A61K49/0034 ,  A61K9/0021 ,  A61K49/0043 ,  A61K49/0058 ,  A61M5/46 ,  A61M37/00

摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly a diagnostic agent to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents in that it provides among other benefits, rapid uptake into the local lymphatics, improved targeting to a particular tissue, improved bioavailability, improved tissue bioavailability, improved tissue specific kinetics, improved deposition of a pre-selected volume of the agent to be administered, and rapid biological and pharmacodynamics and biological and pharmacokinetics. This invention provides methods for rapid transport of agents through lymphatic vasculature accessed by intradermal delivery of the agent. Methods of the invention are particularly useful for delivery of diagnostic agents.

摘要翻译： 本发明涉及用于将一种或多种生物活性剂特别是诊断剂递送到受试者皮肤的真皮内隔室的方法和装置。 本发明提供了递送生物活性剂的改进方法，因为它提供了其他益处，快速摄入局部淋巴管，改善对特定组织的靶向，改善的生物利用度，改善的组织生物利用度，改善的组织特异性动力学，改进的沉积 预先选定体积的药物，以及快速的生物和药效学以及生物和药代动力学。 本发明提供了通过皮内递送试剂获得的通过淋巴脉管系统快速转运药剂的方法。 本发明的方法对于递送诊断剂特别有用。

公开(公告)号：US20050095676A1

公开(公告)日：2005-05-05

申请号：US10913944

申请日：2004-08-06

申请人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

发明人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/59 ,  C07K16/26 ,  A61K38/22 ,  C07H21/04 ,  C07K14/565

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/59 ,  C07K16/26 ,  C07K2317/34

摘要： The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.

摘要翻译： 本发明提供新的分离的ARP / BRP多核苷酸和由ARP / BRP多核苷酸编码的膜相关或分泌的多肽。 还提供了ARP和BRP蛋白多聚体。 还提供免疫特异性结合ARP / BRP多肽或ARP / BRP多肽的任何衍生物，变体，突变体或片段，ARP / BRP多聚体多核苷酸或抗体的抗体。 本发明还提供了其中使用ARP / BRP多肽，多聚体，多核苷酸和抗体来检测和治疗广泛的病理状态的方法，例如， 生殖障碍，以及其他用途。

公开(公告)号：US4312701A

公开(公告)日：1982-01-26

申请号：US204942

申请日：1980-11-07

申请人： Robert Campbell

发明人： Robert Campbell

IPC分类号： D21B1/32 ,  D21C5/02

CPC分类号： D21B1/32 ,  Y02W30/646

摘要： A method for defibrating waste paper and dispersing contained asphalt and wax contaminants within the fibers. The waste paper is initially pulped with water and the resulting stock is then contacted with a high pressure stream of steam having a velocity in the range of 1200 to 1600 ft./sec. The mixture of steam and stock is passed through a mixing tube under highly turbulent conditions to defibrate the waste paper and disperse any asphalt, waxes, and other contaminants throughout the separated fibers. The resulting stock can be used in papermaking processes, particularly for the production of paperboard products.

摘要翻译： 一种解决废纸的方法，并在纤维中分散含有沥青和蜡污染物。 废纸最初用水打浆，然后使得到的原料与速度在1200至1600英尺/秒范围内的高压蒸汽流接触。 蒸汽和原料的混合物在高度湍流条件下通过混合管，以对废纸进行解纤，并将所有沥青，蜡和其它污染物分散在分离的纤维中。 所得到的原料可用于造纸工艺，特别是用于生产纸板产品。