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    Determining onsets and offsets of cardiac depolarization and repolarization waves
    121.
    发明授权
    Determining onsets and offsets of cardiac depolarization and repolarization waves 有权
    确定心脏去极化和复极波的起始点和偏移

    公开(公告)号：US09572505B2

    公开(公告)日：2017-02-21

    申请号：US13780240

    申请日：2013-02-28

    Applicant: MEDTRONIC, INC.

    Inventor： Subham Ghosh ,  Teresa A. Whitman

    IPC: A61B5/0452 ,  A61B5/04 ,  A61B5/00 ,  A61N1/365 ,  A61N1/368

    CPC classification number: A61B5/04012 ,  A61B5/0452 ,  A61B5/4836 ,  A61B5/7239 ,  A61N1/36507 ,  A61N1/36585 ,  A61N1/3684

    Abstract: In one example, a method includes determining a slope of a cardiac electrogram. The method may also include determining a threshold value based on a maximum of the slope of the cardiac electrogram. The method may further include identifying a last point of the cardiac electrogram before the slope of the cardiac electrogram crosses the threshold as one of an onset or an offset of a wave. In another example, the method further includes receiving an indication of local ventricular motion associated with a cardiac contraction, and determining an electromechanical delay between the identified onset and the local ventricular motion. Some examples include providing the electromechanical delay for configuration of cardiac resynchronization therapy.

    Abstract translation: 在一个示例中，一种方法包括确定心电图的斜率。 该方法还可以包括基于心电图的斜率的最大值来确定阈值。 该方法还可以包括在心电图的斜率跨越阈值之前识别心电图的最后一点，作为波的开始或偏移之一。 在另一示例中，该方法还包括接收与心脏收缩相关的局部心室运动的指示，以及确定所识别的发作与局部心室运动之间的机电延迟。 一些例子包括提供用于配置心脏再同步治疗的机电延迟。

    CONFIRMING SENSED ATRIAL EVENTS FOR PACING DURING RESYNCHRONIZATION THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM
    122.
    发明申请
    CONFIRMING SENSED ATRIAL EVENTS FOR PACING DURING RESYNCHRONIZATION THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM 有权
    在心脏医疗设备和医疗设备系统中进行康复治疗期间确认感染的感染事件

    公开(公告)号：US20170014629A1

    公开(公告)日：2017-01-19

    申请号：US14801049

    申请日：2015-07-16

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Juan Du ,  Saul E Greenhut ,  Michael T Hemming

    IPC: A61N1/368 ,  A61N1/375

    CPC classification number: A61N1/3682 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/7246 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/3756

    Abstract: A medical device and medical device system for controlling delivery of therapeutic stimulation pulses that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to receive the trigger signal and deliver therapy to the patient in response to the emitted trigger signal, and a processor positioned within the sensing device, the processor configured to determine whether the sensed cardiac signal exceeds a possible P-wave threshold, compare a portion of the sensed cardiac signal to a P-wave template having a sensing window having a length less than a width of the P-wave, confirm an occurrence of a P-wave signal in response to the comparing, emit the trigger signal in response to the occurrence of a P-wave signal being confirmed, and inhibit delivery of the emitting signal in response to the occurrence of a P-wave signal not being confirmed.

    Abstract translation: 一种医疗装置和医疗装置系统，用于控制治疗性刺激脉冲的传送，所述医疗装置和医疗装置系统包括感测装置，用于感测心脏信号并响应感测到的心脏信号发射触发信号;治疗递送装置，用于接收触发信号并将治疗递送至 所述患者响应于所发射的触发信号，以及位于所述感测装置内的处理器，所述处理器被配置为确定所感测到的心脏信号是否超过可能的P波阈值，将感测到的心脏信号的一部分与P波 具有小于P波宽度的感测窗口的模板，确认响应于比较的P波信号的出现，响应于确认的P波信号的出现而发出触发信号 并且响应于未被确认的P波信号的发生而抑制发射信号的传递。

    Effective capture test
    123.
    发明授权
    Effective capture test 有权
    有效的捕获测试

    公开(公告)号：US09320905B2

    公开(公告)日：2016-04-26

    申请号：US13707391

    申请日：2012-12-06

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Robert W. Stadler

    IPC: A61N1/365 ,  A61N1/37 ,  A61B5/0452 ,  A61B5/00 ,  A61N1/362 ,  A61N1/372

    CPC classification number: A61N1/371 ,  A61B5/0452 ,  A61B5/4836 ,  A61B5/686 ,  A61N1/3627 ,  A61N1/37247

    Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining the efficacy of CRT through use of an effective capture test (ECT). One or more embodiments comprises sensing a signal in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal. Exemplary features parsed from the signal include a maximum amplitude, a maximum time associated with the maximum amplitude, a minimum amplitude, and a minimum time associated with the minimum amplitude. The data is evaluated through use of the ECT. By employing the ECT, efficacy of CRT is easily and automatically evaluated.

    Abstract translation: 本公开涉及心脏起搏方法和系统，更具体地，涉及心脏再同步治疗（CRT）。 特别地，本公开涉及通过使用有效捕获测试（ECT）来确定CRT的功效。 一个或多个实施例包括响应于心室起搏刺激来感测信号。 通过信号处理，从信号中解析出许多特征。 从信号解析的示范性特征包括最大幅度，与最大幅度相关联的最大时间，最小幅度以及与最小幅度相关联的最小时间。 通过使用ECT评估数据。 通过使用ECT，CRT的功效易于自动评估。

    Criteria for optimal electrical resynchronization during biventricular pacing
    125.
    发明授权
    Criteria for optimal electrical resynchronization during biventricular pacing 有权
    双心室起搏期间最佳电再同步的标准

    公开(公告)号：US09155897B2

    公开(公告)日：2015-10-13

    申请号：US13886884

    申请日：2013-05-03

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Robert W Stadler

    IPC: A61N1/37 ,  A61B5/0452 ,  A61N1/368

    CPC classification number: A61N1/3686 ,  A61B5/0452 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/3706

    Abstract: Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Computing a first degree of resynchronization based on a sum of differences of activation times and corresponding activation times. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Computing a second degree of resynchronization based on the sum of differences of activation times and corresponding activation times. Selecting one of the left ventricular electrodes for delivery of subsequent pacing pulses based on the computed degrees of resynchronization.

    Abstract translation: 通常，本公开涉及使用右心室电极和多个左心室电极的一个或多个心脏起搏方法或系统。 使用右心室电极和左心室电极中的第一个进行起搏，并测量其他左心室电极的活化时间。 使用右心室电极和第二个心室电​​极进行起搏，并测量其他左心室电极的活化时间。 基于激活时间的差异和相应的激活时间的总和来计算第一程度的再同步。 使用右心室电极和第二个心室电​​极进行起搏，并测量其他左心室电极的活化时间。 基于激活时间的差异和相应的激活时间的总和计算第二度的再同步度。 基于所计算出的再同步度，选择一个左心室电极用于递送随后的起搏脉冲。

    METHODS AND SYSTEMS FOR IDENTIFYING REASONS FOR INEFFECTIVE LEFT VENTRICULAR CAPTURE IN CARDIAC RESYNCHRONIZATION THERAPY BASED ON EGM MORPHOLOGY
    126.
    发明申请
    METHODS AND SYSTEMS FOR IDENTIFYING REASONS FOR INEFFECTIVE LEFT VENTRICULAR CAPTURE IN CARDIAC RESYNCHRONIZATION THERAPY BASED ON EGM MORPHOLOGY 有权
    用于识别基于EGM形态的心脏再生治疗中无效左心室收缩的原因的方法和系统

    公开(公告)号：US20150246235A1

    公开(公告)日：2015-09-03

    申请号：US14193186

    申请日：2014-02-28

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh

    IPC: A61N1/37

    CPC classification number: A61N1/3712 ,  A61B5/04525 ,  A61B5/4836 ,  A61B5/6869 ,  A61B5/7282 ,  A61N1/37247

    Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining the efficacy of CRT through use of an effective capture test (ECT). One or more embodiments comprises sensing a signal in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal. Exemplary features parsed from the signal include a maximum amplitude, a maximum time associated with the maximum amplitude, a minimum amplitude, and a minimum time associated with the minimum amplitude. The data is evaluated through use of the ECT. By employing the ECT, efficacy of CRT is easily and automatically evaluated. In one or more other embodiments, the reason for ineffective capture is displayed to the user. Exemplary reasons for ineffective capture include pseudo-fusion pacing and lack of capture of the ventricle.

    Abstract translation: 本公开涉及心脏起搏方法和系统，更具体地，涉及心脏再同步治疗（CRT）。 特别地，本公开涉及通过使用有效捕获测试（ECT）来确定CRT的功效。 一个或多个实施例包括响应于心室起搏刺激来感测信号。 通过信号处理，从信号中解析出许多特征。 从信号解析的示范性特征包括最大幅度，与最大幅度相关联的最大时间，最小幅度以及与最小幅度相关联的最小时间。 通过使用ECT评估数据。 通过使用ECT，CRT的功效易于自动评估。 在一个或多个其他实施例中，向用户显示无效捕获的原因。 无效捕获的示例性原因包括伪融合起搏和缺乏心室的捕获。

    ANODAL CAPTURE DETECTION
    127.
    发明申请
    ANODAL CAPTURE DETECTION 有权
    阳极检测

    公开(公告)号：US20150182751A1

    公开(公告)日：2015-07-02

    申请号：US14145053

    申请日：2013-12-31

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Todd Sheldon

    IPC: A61N1/37

    CPC classification number: A61N1/371 ,  A61N1/362

    Abstract: Systems and methods are described herein for determining whether anodal capture of the right ventricle is occurring when delivering left ventricular pacing with a cross-chamber pacing vector. The systems and methods may be measure cross-chamber sense times from left ventricular pacing and right ventricular pacing and compare the cross-chamber sense times to determine whether anodal capture of the right ventricle is occurring.

    Abstract translation: 本文描述了系统和方法，用于确定当用横向室起搏向量递送左心室起搏时是否发生右心室的阳极捕获。 系统和方法可以测量来自左心室起搏和右心室起搏的交叉室感测时间，并且比较横室感测时间以确定是否正在发生右心室的阳极捕获。

    BIOELECTRIC SENSOR DEVICE AND METHODS
    129.
    发明申请
    BIOELECTRIC SENSOR DEVICE AND METHODS 有权
    BIOELECTRIC传感器装置及方法

    公开(公告)号：US20150157225A1

    公开(公告)日：2015-06-11

    申请号：US14227719

    申请日：2014-03-27

    Applicant: Medtronic, Inc.

    Inventor： Jeffrey Gillberg ,  Subham Ghosh

    IPC: A61B5/04 ,  A61B5/00

    CPC classification number: A61B5/04085 ,  A61B5/04 ,  A61B5/04087 ,  A61B5/6805 ,  A61B5/6823 ,  A61B5/683 ,  A61B5/6832 ,  A61B2562/046 ,  A61B2562/164

    Abstract: Various embodiments of a bioelectric sensor device for sensing bioelectric data from a human body are disclosed. The device can include a flexible substrate, a plurality of sensors arranged in a sensor array on a sensor array portion of the substrate, an electrically conductive network located on the substrate, and a plurality of lines of weakness formed in the sensor array portion of the substrate. In one or more embodiments, each line of weakness is configured to enhance separation of the sensor array portion of the substrate along a separation line that extends between at least two sensors of the plurality of sensors. The device can also include a left reference electrode proximate a distal end of a left reference electrode arm of the substrate and a right reference electrode proximate a distal end of a right reference electrode arm of the substrate.

    Abstract translation: 公开了用于感测人体生物电数据的生物电传感器装置的各种实施例。 该装置可以包括柔性基板，布置在基板的传感器阵列部分上的传感器阵列中的多个传感器，位于基板上的导电网络，以及形成在传感器阵列部分中的多个弱线 基质。 在一个或多个实施例中，每条弱线被配置为增强沿着在多个传感器的至少两个传感器之间延伸的分隔线的衬底的传感器阵列部分的分离。 该装置还可以包括靠近基板的左参考电极臂的远端的左参考电极和靠近基板的右参考电极臂的远端的右参考电极。

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