公开(公告)号：US20160356722A1

公开(公告)日：2016-12-08

申请号：US15222674

申请日：2016-07-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N21/76 ,  C12Q1/00 ,  B01L9/00 ,  G01N33/543 ,  B01J19/00

CPC classification number: G01N21/76 ,  B01J19/0046 ,  B01J2219/00653 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/5029 ,  B01L9/527 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0688 ,  B33Y80/00 ,  C12Q1/001 ,  C40B40/10 ,  G01N27/30 ,  G01N33/5438 ,  G01N2458/30 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。

公开(公告)号：US20160069872A1

公开(公告)日：2016-03-10

申请号：US14847761

申请日：2015-09-08

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  G01N33/68 ,  C12Q1/68

CPC classification number: B01L3/50853 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

Abstract translation: 本发明涉及用于进行固相结合测定的方法。 一个实例是具有改进的分析物特异性的测定方法，其中特异性受到非特异性结合相互作用的存在的限制。

公开(公告)号：US20160003822A1

公开(公告)日：2016-01-07

申请号：US14854514

申请日：2015-09-15

Applicant: Meso Scale Technologies, LLC ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：USD721184S1

公开(公告)日：2015-01-13

申请号：US29486611

申请日：2014-04-01

Applicant: Meso Scale Technologies, LLC

Designer： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Manish Kochar ,  Sandor Kovacs ,  Aaron Leimkuehler ,  Rodger Darin Osborne ,  Jacob N. Wohlstadter

公开(公告)号：US20140336070A1

公开(公告)日：2014-11-13

申请号：US14319167

申请日：2014-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: G01N33/573 ,  G01N33/53 ,  G01N21/76 ,  G01N33/58

CPC classification number: G01N33/573 ,  C12Q1/485 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N2333/91205 ,  G01N2458/30 ,  G01N2458/40 ,  Y10S435/967 ,  Y10S435/968 ,  Y10T436/10 ,  Y10T436/108331

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

Abstract translation: 本发明涉及使用磷酸化特异性抗体和基本上不含无机磷酸盐的缓冲组合物的磷酸化肽或蛋白质的改进的电化学发光测定方法。

公开(公告)号：US20140220006A1

公开(公告)日：2014-08-07

申请号：US14168590

申请日：2014-01-30

Applicant: Meso Scale Technologies, LLC

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574 ,  A61K39/395 ,  A61K31/5377 ,  A61K31/555 ,  A61K31/7048 ,  A61K31/337 ,  A61K31/7068 ,  A61K31/475 ,  A61K31/4745 ,  A61K33/24 ,  A61K31/517

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Abstract translation: 本发明涉及诊断患者肺癌的方法，以及监测肺癌进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。