公开(公告)号：US06258556B1

公开(公告)日：2001-07-10

申请号：US08188275

申请日：1994-01-28

申请人： George Uhl ,  Peter Johnson ,  Antonio M. Persico ,  Jia Bei Wang

发明人： George Uhl ,  Peter Johnson ,  Antonio M. Persico ,  Jia Bei Wang

IPC分类号： C12P2106

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/705

摘要： A human &mgr; opiate receptor cDNA has been identified from a cerebral cortical CDNA library using sequences from the rat &mgr; opiate receptor CDNA. The human &mgr; opiate receptor (h&mgr;OR1) shares 95% amino acid identity with the rat sequence. The expressed &mgr;OR1 recognizes tested opiate drugs and opioid peptides in a sodium- and GTP-sensitive fashion with affinities virtually identical to those displayed by the rat &mgr; opiate receptor. Effects on cyclic AMP are similar to those noted for the rat &mgr; opiate receptor. Overlapping genomic clones spanning 50 kilobasepairs and hybridizing with the h&mgr;OR1 cDNA contains exon sequences encoding the entire open reading frame of the human A opiate receptor are described. Analysis of hybridization to DNA prepared from human rodent hybrid cell lines and chromosomal in situ hybridization studies indicate localization to 6q24-25. An MspI polymorphism, producing a 3.7 kb band, is being used to assess this gene's involvement in neuropsychiatric disorders involving opiatergic systems.

摘要翻译： 已经使用来自大鼠mu鸦片受体CDNA的序列从大脑皮质CDNA文库中鉴定了人类鸦片剂受体cDNA。 人类鸦片剂受体（hmuOR1）与大鼠序列具有95％的氨基酸同一性。 表达的muOR1以钠和GTP敏感的方式识别测试的阿片样物质和阿片样物质肽，其亲和力与大鼠mu鸦片受体显示的亲和力几乎相同。 对环AMP的作用与大鼠mu鸦片受体相似。 描述跨越50千碱基并与hmuOR1 cDNA杂交的重叠基因组克隆包含编码人A阿片受体的整个开放阅读框的外显子序列。 从人类啮齿动物杂交细胞系制备的DNA杂交分析和染色体原位杂交研究表明定位于6q24-25。 正在使用产生3.7kb带的MspI多态性来评估该基因参与涉及opiatgic系统的神经精神障碍。

公开(公告)号：US5650443A

公开(公告)日：1997-07-22

申请号：US470705

申请日：1995-06-06

申请人： Peter Johnson ,  Barry E. Watkins ,  Eric W. Harris

发明人： Peter Johnson ,  Barry E. Watkins ,  Eric W. Harris

IPC分类号： A61K31/165 ,  A61K31/195

CPC分类号： A61K31/195 ,  A61K31/165

摘要： 2-amino-N-(1,2-diphenyl-1-methylethyl) acetamide (remacemide) or a phamaceutically acceptable salt thereof, and L-dopa, are useful in conjunction with one another in the treatment of Parkinson's disease. Pharmaceutical products and formulations comprising these active agents are provided.

摘要翻译： 2-氨基-N-（1,2-二苯基-1-甲基乙基）乙酰胺（remacemide）或其药学上可接受的盐和左旋多巴在治疗帕金森病中彼此有用。 提供了包含这些活性剂的药物产品和制剂。

公开(公告)号：US11058793B2

公开(公告)日：2021-07-13

申请号：US14117381

申请日：2012-05-11

申请人： Anne Marie Wibaux ,  Peter Johnson

发明人： Anne Marie Wibaux ,  Peter Johnson

IPC分类号： A61L24/00 ,  A61L26/00 ,  C09J11/00 ,  C08L75/04 ,  C08K7/16

摘要： Methods for forming and incorporating microparticles containing one or more active agents into adhesives are described. The methods involve spray drying a liquid of the one or more active agents and obtaining the active agent in a particulate form. The dry powder is then blended or otherwise incorporated with the adhesive of interest. Also described are various medical products utilizing the adhesive and one or more active agents in microparticle form, and related methods of use.

公开(公告)号：US09981918B2

公开(公告)日：2018-05-29

申请号：US14241374

申请日：2012-08-28

申请人： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  Peter Johnson ,  Ignacio Muñoz-Sanjuán ,  Stephen Martin Courtney ,  William Mitchell ,  Christopher John Brown ,  Paula C. De Aguiar Pena

发明人： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  Peter Johnson ,  Ignacio Muñoz-Sanjuán ,  Stephen Martin Courtney ,  William Mitchell ,  Christopher John Brown ,  Paula C. De Aguiar Pena

IPC分类号： C07D237/28 ,  A61K31/70 ,  C07D239/28 ,  C07D405/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/10 ,  C07D239/42 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/052 ,  C07H13/10 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

CPC分类号： C07D239/28 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/052 ,  C07H13/10

摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

公开(公告)号：US08990557B2

公开(公告)日：2015-03-24

申请号：US13029871

申请日：2011-02-17

申请人： Farhang Kassaei ,  Neeti Deshmukh ,  Peter Johnson ,  Franco Travostino ,  Sachin Khanna ,  Anand Bahety ,  Benoy Antony

发明人： Farhang Kassaei ,  Neeti Deshmukh ,  Peter Johnson ,  Franco Travostino ,  Sachin Khanna ,  Anand Bahety ,  Benoy Antony

IPC分类号： H04L29/06 ,  H04L9/32 ,  G06F21/33

CPC分类号： H04L9/3234 ,  G06F21/335 ,  H04L63/20

摘要： Systems and methods for implementing an identity assertion framework to authenticate a user in a federation of security domains are provided. A first security token service (STS) is configured to receive a request for a first token from a consumer and to issue the first token to the consumer. The first STS is associated with a first security domain, and the first token is issued according to a first issuing policy of the first security domain. A service provider within a second security domain receives the first token and makes a determination whether the first token is invalid in the second security domain. A second STS receives the first token from the service provider, determines that the first token was issued by the first STS, and validates the first token according to a federation policy between the first security domain and the second security domain.

摘要翻译： 提供了用于实现身份断言框架以验证安全域的联合中的用户的系统和方法。 第一安全令牌服务（STS）被配置为从消费者接收对第一令牌的请求，并向消费者发出第一令牌。 第一STS与第一安全域相关联，并且根据第一安全域的第一发布策略发出第一令牌。 第二安全域内的服务提供商接收第一令牌并确定第二安全域中的第一令牌是否无效。 第二个STS从服务提供商接收第一令牌，确定第一个令牌是由第一个STS发出的，并根据第一个安全域和第二个安全域之间的联盟策略来验证第一个令牌。

公开(公告)号：US08745585B2

公开(公告)日：2014-06-03

申请号：US13339892

申请日：2011-12-29

申请人： Christina Watters ,  Peter Johnson ,  Robert S. Baker

发明人： Christina Watters ,  Peter Johnson ,  Robert S. Baker

IPC分类号： G06F7/00 ,  G06F17/00 ,  G06F15/173 ,  H04L29/06 ,  H04L9/32 ,  G06F9/44 ,  G06F9/46

CPC分类号： G06F8/36

摘要： System and method for generating meta-data for a product is disclosed. An artifact repository stores first artifacts for building the product. The artifact repository stores first meta-data for one or more of the artifacts in the repository. A build manager builds second artifacts for the product from source code and one or more of the first artifacts based on information in a project script. The build manager is adapted to combine the first meta-data for each of the one or more of the first artifacts used to build the second artifact to form second meta-data for each of the second artifacts.

摘要翻译： 公开了用于产生产品元数据的系统和方法。 工件存储库存储用于构建产品的第一个工件。 工件存储库存储存储库中一个或多个工件的第一个元数据。 构建管理器根据项目脚本中的信息，从源代码和一个或多个第一个工件构建产品的第二个工件。 构建管理器适于组合用于构建第二工件的一个或多个第一工件中的每一个的第一元数据以形成第二工件中的每一个的第二元数据。

公开(公告)号：US20130249023A1

公开(公告)日：2013-09-26

申请号：US13427856

申请日：2012-03-22

申请人： Steven Adler ,  Peter Johnson ,  Ira Oaktree Wygant

发明人： Steven Adler ,  Peter Johnson ,  Ira Oaktree Wygant

IPC分类号： H01L29/84 ,  H01L21/02

CPC分类号： H01L29/84 ,  B06B1/0292 ,  G01N29/2406 ,  H01L27/0805 ,  H01L29/94

摘要： A high-frequency capacitive micromachined ultrasonic transducer (CMUT) has a silicon membrane and an overlying metal silicide layer that together form a conductive structure which can vibrate over a cavity. The CMUT also has a metal structure that touches a group of conductive structures. The metal structure has an opening that extends completely through the metal structure to expose the conductive structure.

摘要翻译： 高频电容微加工超声波换能器（CMUT）具有硅膜和上覆的金属硅化物层，它们一起形成可在空腔上振动的导电结构。 CMUT还具有接触一组导电结构的金属结构。 金属结构具有完全延伸穿过金属结构的开口以暴露导电结构。

公开(公告)号：US20130174117A1

公开(公告)日：2013-07-04

申请号：US13339880

申请日：2011-12-29

申请人： Christina Watters ,  Peter Johnson ,  Robert S. Baker

发明人： Christina Watters ,  Peter Johnson ,  Robert S. Baker

IPC分类号： G06F9/44 ,  G06F9/45

CPC分类号： G06F11/3664 ,  G06F8/71

摘要： System and method for forming a cloud appliance. The system includes a management server, an artifact repository, a continuous integration server, and build managers. The management server includes source code and a project script for forming the cloud appliance. The artifact repository stores artifacts required to build the cloud appliance and artifacts that comprise the built cloud appliance. The continuous integration server manages a build process, unit test process, and deployment process based on the project script. The build managers build the source code for customizing the virtual machine and store the built source code as the second artifacts in the artifact repository. The continuous integration server instantiates the virtual machine from template and customizes the virtual machine to form a customized virtual machine using the artifacts specified in the project script, a customization process for each of the artifacts based on a type of the artifact.

摘要翻译： 用于形成云设备的系统和方法。 该系统包括管理服务器，工件存储库，持续集成服务器和构建管理器。 管理服务器包括用于形成云设备的源代码和项目脚本。 工件存储库存储构建云设备所需的工件，以及组成构建的云设备的工件。 持续集成服务器根据项目脚本管理构建过程，单元测试过程和部署过程。 构建管理器构建用于自定义虚拟机的源代码，并将构建的源代码作为第二个工件存储在工件存储库中。 连续集成服务器从模板中实例化虚拟机，并使用项目脚本中指定的工件，基于工件类型的每个工件的自定义过程来自定义虚拟机以形成自定义虚拟机。

公开(公告)号：US20130140654A1

公开(公告)日：2013-06-06

申请号：US13309773

申请日：2011-12-02

申请人： Steven Adler ,  Peter Johnson ,  Ira Oaktree Wygant

发明人： Steven Adler ,  Peter Johnson ,  Ira Oaktree Wygant

IPC分类号： H01L29/84 ,  H01L21/02

CPC分类号： H01L29/84 ,  B06B1/0292 ,  H01L29/66007

摘要： A capacitive micromachined ultrasonic transducer (CMUT), which has a conductive structure that can vibrate over a cavity, has a number of vent holes that are formed in the bottom surface of the cavity. The vent holes eliminate the deflection of the CMUT membrane due to atmospheric pressure which, in turn, allows the CMUT to receive and transmit low frequency ultrasonic waves.

摘要翻译： 具有能够在空腔上振动的导电结构的电容式微加工超声波换能器（CMUT）具有形成在空腔的底表面中的多个通气孔。 通气孔消除了由于大气压力导致的CMUT膜的挠曲，这进一步允许CMUT接收和传输低频超声波。

公开(公告)号：US08324006B1

公开(公告)日：2012-12-04

申请号：US12589754

申请日：2009-10-28

申请人： Steven J. Adler ,  Peter Johnson ,  Ira Wygant

发明人： Steven J. Adler ,  Peter Johnson ,  Ira Wygant

IPC分类号： H01H9/00 ,  H01L21/449

CPC分类号： B06B1/0292

摘要： A method includes forming first isolation trenches in a first side of a first semiconductor-on-insulator (SOI) structure to electrically isolate multiple portions of the first SOI structure from each other. The method also includes bonding a second SOI structure to the first SOI structure to form multiple cavities between the SOI structures. The method further includes forming conductive plugs through a second side of the first SOI structure and forming second isolation trenches in the second side of the first SOI structure around the conductive plugs. In addition, the method includes removing portions of the second SOI structure to leave a membrane bonded to the first SOI structure. The isolated portions of the first SOI structure, the cavities, and the membrane form multiple capacitive micromachined ultrasonic transducer (CMUT) elements. Each CMUT element is formed in one of the isolated portions of the first SOI structure and includes multiple CMUT cells.

摘要翻译： 一种方法包括在第一绝缘体绝缘体（SOI）结构的第一侧中形成第一隔离沟槽，以将第一SOI结构的多个部分彼此电隔离。 该方法还包括将第二SOI结构接合到第一SOI结构以在SOI结构之间形成多个空腔。 该方法还包括通过第一SOI结构的第二侧形成导电插塞，并在导电插塞周围的第一SOI结构的第二侧形成第二隔离沟槽。 此外，该方法包括去除第二SOI结构的部分以留下结合到第一SOI结构的膜。 第一SOI结构，空腔和膜的隔离部分形成多个电容微加工超声换能器（CMUT）元件。 每个CMUT元件形成在第一SOI结构的隔离部分之一中，并且包括多个CMUT单元。