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公开(公告)号:US20190300904A1
公开(公告)日:2019-10-03
申请号:US16341504
申请日:2017-10-13
Applicant: University of Massachusetts
Inventor: Guangping Gao , Guangchao Xu , Phillip Tai , Yuquan Wei , Li Luo
IPC: C12N15/86 , C07K14/005 , A61K35/761 , A01K67/027
Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
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公开(公告)号:US20190276848A1
公开(公告)日:2019-09-12
申请号:US16364763
申请日:2019-03-26
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113 , A61K31/713
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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123.
公开(公告)号:US20190142968A1
公开(公告)日:2019-05-16
申请号:US16091675
申请日:2017-04-05
Applicant: University of Massachusetts
Inventor: Gyongyi Szabo , Guangping Gao , Abhishek Satishchandran
Abstract: In some aspects, the disclosure relates to methods and compositions for modulation of miR-122 expression in a cell or a subject. In some embodiments, methods and compositions described by the disclosure are useful for the treatment of liver-associated diseases (e.g., chronic liver disease, alcoholic liver disease).
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公开(公告)号:US10072251B2
公开(公告)日:2018-09-11
申请号:US15120294
申请日:2015-02-19
Applicant: University of Massachusetts
Inventor: Guangping Gao , Li Zhong
IPC: C12N15/113 , C12N7/00 , C12N15/86 , A61K48/00 , A61K38/17
CPC classification number: C12N7/00 , A61K38/1709 , A61K48/0058 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2710/10332 , C12N2710/10342 , C12N2750/14122 , C12N2750/14143 , C12N2750/14171
Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
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公开(公告)号:US10035825B2
公开(公告)日:2018-07-31
申请号:US15007559
申请日:2016-01-27
Applicant: University of Massachusetts
Inventor: Guangping Gao , Terence Flotte , Jun Xie
IPC: C12N7/00 , A61K39/23 , C07K14/005 , C12N15/86 , A61K31/7088 , A61K35/76 , A61K48/00
CPC classification number: C07K14/005 , A61K31/7088 , A61K35/76 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
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公开(公告)号:US20180148738A9
公开(公告)日:2018-05-31
申请号:US15613646
申请日:2017-06-05
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , C12N15/864 , A61K38/50 , A61K48/00 , C12N7/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/63
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20170349911A1
公开(公告)日:2017-12-07
申请号:US15613646
申请日:2017-06-05
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K38/50 , A61K48/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/864 , C12N7/00 , C12N15/63
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20170166925A1
公开(公告)日:2017-06-15
申请号:US15306543
申请日:2015-04-24
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip D. Zamore , Shaoyong Li
IPC: C12N15/86 , C12N7/00 , C12N15/117 , A61K48/00 , A61K38/51 , C07K16/10 , A61K38/44 , A61K38/28 , A61K38/48 , C07K16/28 , C07K16/32 , C07K16/22 , C12N15/113 , A61K38/17
CPC classification number: C12N15/86 , A61K38/1709 , A61K38/28 , A61K38/446 , A61K38/4846 , A61K38/51 , A61K48/0008 , C07K16/10 , C07K16/22 , C07K16/2875 , C07K16/2887 , C07K16/32 , C12N7/00 , C12N15/113 , C12N15/117 , C12N2310/141 , C12N2310/17 , C12N2320/30 , C12N2330/51 , C12N2710/10322 , C12N2710/10332 , C12N2750/14143 , C12N2760/00042 , C12N2830/008 , C12Y115/01001 , C12Y304/21022 , C12Y401/01028 , C12N2310/113 , C12N2310/13
Abstract: The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.
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公开(公告)号:US20160208257A1
公开(公告)日:2016-07-21
申请号:US14995699
申请日:2016-01-14
Applicant: University of Massachusetts
Inventor: Guangping Gao , Phillip D. Zamore , Jun Xie
IPC: C12N15/113 , C12N15/86 , C12Q1/68 , C12N7/00
CPC classification number: C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/113 , C12N2320/32 , C12N2330/51 , C12N2750/14143 , C12N2750/14171 , C12Q1/68 , C12Q1/6897
Abstract: The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
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公开(公告)号:US20160206693A1
公开(公告)日:2016-07-21
申请号:US15074714
申请日:2016-03-18
Applicant: University of Massachusetts
Inventor: Michael R. Green , Guangping Gao , Manas Kumar Santra , Sanchita Bhatnagar
IPC: A61K38/17
CPC classification number: A61K38/1709 , A61K35/12 , A61K38/16 , A61K48/00 , A61K48/005 , C12N9/0065
Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
Abstract translation: 治疗受试者的肿瘤的方法包括鉴定具有肿瘤风险或怀疑具有肿瘤的受试者,并向受试者施用有效量的SRPX。
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