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144 条记录 (耗时 0.051 秒)

    Coumarin derivatives as ion channel openers
    125.
    发明授权
    Coumarin derivatives as ion channel openers 有权
    香豆素衍生物作为离子通道开放剂

    公开(公告)号：US07662975B2

    公开(公告)日：2010-02-16

    申请号：US11334679

    申请日：2006-01-18

    申请人： Nareshkumar F. Jain ,  Zhihua Sui

    发明人： Nareshkumar F. Jain ,  Zhihua Sui

    IPC分类号： C07D311/02

    CPC分类号： C07D311/16 ,  C07D311/18 ,  C07D493/04

    摘要： The present invention is directed to novel coumarin derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

    摘要翻译： 本发明涉及新颖的香豆素衍生物，含有它们的药物组合物及其在治疗与离子通道如钾通道有关的病症中的用途。

    Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators
    126.
    发明申请
    Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators 审中-公开
    吡啶咪唑和氮杂吲哚作为孕酮受体调节剂

    公开(公告)号：US20100016266A1

    公开(公告)日：2010-01-21

    申请号：US12558812

    申请日：2009-09-14

    申请人： Weiqin Jiang ,  James J. Flordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James J. Flordeliso ,  Zhihua Sui

    IPC分类号： A61K31/437 ,  A61P15/00 ,  A61K31/565

    CPC分类号： C07D471/10 ,  C07D471/04

    摘要： The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

    摘要翻译： 本发明涉及新颖的含杂原子的四环衍生物，含有它们的药物组合物及其在治疗由一种或多种雌激素受体介导的病症中的用途。 本发明的化合物可用于治疗与雌激素消耗相关的病症，例如潮热，阴道干燥，骨质减少和骨质疏松症; 激素敏感性癌症和乳腺，子宫内膜，子宫颈和前列腺增生; 子宫内膜异位症，子宫肌瘤，骨关节炎和避孕药，单独或与孕激素或孕激素拮抗剂联合使用。

    Trisubstituted thiophenes as progesterone receptor modulators
    127.
    发明授权
    Trisubstituted thiophenes as progesterone receptor modulators 失效
    三取代噻吩作为孕酮受体调节剂

    公开(公告)号：US07638525B2

    公开(公告)日：2009-12-29

    申请号：US11255445

    申请日：2005-10-21

    申请人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    IPC分类号： A61K31/4747 ,  A61K31/4545 ,  C07D409/14

    CPC分类号： C07D491/10 ,  C07D409/04 ,  C07D409/14

    摘要： The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

    摘要翻译： 本发明涉及新颖的三取代噻吩衍生物，含有它们的药物组合物及其在治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病中的用途。 这些化合物的临床应用与激素避孕有关，治疗和/或预防继发性痛经，闭经，功能障碍性子宫出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，子宫内膜，卵巢，乳腺，结肠或前列腺的癌和腺癌。 本发明的额外用途包括刺激食物摄取。

    Pyridine imidazoles and aza-indoles as progesterone receptor modulators
    129.
    发明授权
    Pyridine imidazoles and aza-indoles as progesterone receptor modulators 失效
    吡啶咪唑和氮杂 - 吲哚作为孕酮受体调节剂

    公开(公告)号：US07608712B2

    公开(公告)日：2009-10-27

    申请号：US12024189

    申请日：2008-02-01

    申请人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    IPC分类号： C07D211/00 ,  C07D471/02

    CPC分类号： C07D471/10 ,  C07D471/04

    摘要： The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

    摘要翻译： 本发明涉及新颖的含杂原子的四环衍生物，含有它们的药物组合物及其在治疗由一种或多种雌激素受体介导的病症中的用途。 本发明的化合物可用于治疗与雌激素消耗相关的病症，例如潮热，阴道干燥，骨质减少和骨质疏松症; 激素敏感性癌症和乳腺，子宫内膜，子宫颈和前列腺增生; 子宫内膜异位症，子宫肌瘤，骨关节炎和避孕药，单独或与孕激素或孕激素拮抗剂联合使用。