公开(公告)号：US20110136754A1

公开(公告)日：2011-06-09

申请号：US12990214

申请日：2009-04-29

Applicant: Ling Peng ,  Palma Rocchi ,  Juan Iovanna ,  Yi Xia ,  Fanqi Qu ,  Jinqiao Wan ,  Yang Liu ,  Menghua Wang

Inventor： Ling Peng ,  Palma Rocchi ,  Juan Iovanna ,  Yi Xia ,  Fanqi Qu ,  Jinqiao Wan ,  Yang Liu ,  Menghua Wang

IPC: A61K31/7056 ,  C07H19/056 ,  C07D249/10 ,  C07D403/04 ,  A61K31/4196 ,  A61P35/00

CPC classification number: A61K31/7056 ,  A61K31/4196 ,  C07D401/04 ,  C07H19/056

Abstract: The present invention relates to novel compounds of formula (A): in the form of a free base or of an addition salt with an acid. The invention also relates to process of preparation of compounds of formula (A), to composition comprising them and to their application in therapeutics and in particular in cancers.

Abstract translation: 本发明涉及新的式（A）化合物：以游离碱或与酸的加成盐的形式。 本发明还涉及制备式（A）化合物的方法，其包含它们的组合物及其在治疗学中，特别是在癌症中的应用。

公开(公告)号：US20110080944A1

公开(公告)日：2011-04-07

申请号：US12574802

申请日：2009-10-07

Applicant: Feng Pan ,  Yang Liu

Inventor： Feng Pan ,  Yang Liu

IPC: H04N7/26

CPC classification number: H04N19/40 ,  H04N19/102 ,  H04N19/139 ,  H04N19/154 ,  H04N19/159 ,  H04N19/172 ,  H04N19/176 ,  H04N19/46 ,  H04N19/61

Abstract: A transcoder includes a direct transcoder that generates a first portion of a transcoded video stream by reusing a plurality of encoding parameters of a compressed video stream. A cascaded transcoder generates a second portion of the transcoded video stream by decoding the compressed video stream into video data in an uncompressed video format and by re-encoding the video data. A transcoding decision generator generates a transcoding indicator, based on the compressed video stream. A switching module selects the direct transcoder for the first portion of the transcoded video stream and the cascaded transcoder for the second portion of the transcoded video stream, based on the transcoding indicator.

Abstract translation: 代码转换器包括直接代码转换器，其通过重新使用压缩视频流的多个编码参数来生成代码转换的视频流的第一部分。 级联代码转换器通过将压缩视频流解码为未压缩视频格式的视频数据并通过对视频数据进行重新编码来生成转码视频流的第二部分。 代码转换决策发生器基于压缩的视频流生成代码转换指示符。 基于代码转换指示符，切换模块为代码转换的视频流的第一部分和用于转码视频流的第二部分的级联代码转换器选择直接代码转换器。

公开(公告)号：US20110078545A1

公开(公告)日：2011-03-31

申请号：US12894274

申请日：2010-09-30

Applicant: Yin He ,  Yi Fan Lin ,  Yang Liu ,  Hao Yang

Inventor： Yin He ,  Yi Fan Lin ,  Yang Liu ,  Hao Yang

IPC: H03M13/15 ,  G06F11/10

CPC classification number: H04L1/0047 ,  H03M13/159 ,  H03M13/33 ,  H03M13/333 ,  H03M13/6561 ,  H04L7/048

Abstract: The present invention discloses a frame boundary detection system and a synchronization system for a data stream received by an Ethernet Forward Error Correction layer. The frame boundary detection system includes a shifter, two descramblers, a syndrome generator and trapper. The error trapper includes a big-little endian mode controller for controlling the big-little endian conversion of the error trapper. If the error trapper operates in the big endian mode, the error trapper implements the function of the syndrome generator, operates at the same time with the syndrome generator, and performs a second FEC check, wherein when the shifter performs the FEC check by intercepting data with a length of one frame plus A bits, two start positions of the frame can be verified, where A is a positive integer less than a length of one frame. The invention can improve the frame boundary detection speed and the frame synchronization speed, and increase only a few hardware overheads.

Abstract translation: 本发明公开了一种用于由以太网前向纠错层接收的数据流的帧边界检测系统和同步系统。 帧边界检测系统包括移位器，两个解扰器，综合征发生器和捕捉器。 误差捕获器包括一个大小端模式控制器，用于控制误差捕获器的大小端位转换。 如果错误捕获器以大端模式工作，则误差捕获器实现校正子发生器的功能，同时与校正子发生器一起工作，并执行第二个FEC校验，其中当移位器通过截取数据执行FEC检查 长度为一帧加A位，可以验证帧的两个起始位置，其中A是小于一帧长度的正整数。 本发明可以提高帧边界检测速度和帧同步速度，并且仅增加少量的硬件开销。

公开(公告)号：US20110064746A1

公开(公告)日：2011-03-17

申请号：US12716842

申请日：2010-03-03

Applicant: Yang Liu ,  Pan Zheng ,  Guo-Yun Chen ,  Xi Chen ,  Steve Kunkel ,  Xincheng Zheng

Inventor： Yang Liu ,  Pan Zheng ,  Guo-Yun Chen ,  Xi Chen ,  Steve Kunkel ,  Xincheng Zheng

IPC: A61K39/395 ,  A61P29/00

CPC classification number: C07K16/18 ,  A61K31/351 ,  A61K38/177 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

Abstract translation: 本技术提供了通过施用包含一种或多种CD24的组合物来治疗组织损伤相关免疫失调调节的方法和组合物; CD24片段，变体和衍生物，CD24Fc融合蛋白; HMBG1结合蛋白，HMBG1盒B结合蛋白; HMGB1的多肽，单克隆，重组，嵌合，人源化scFv抗体和HMGB1抗体片段或HMGB1片段的抗体以及结合并抑制HMGB1盒B活性的抗体的拮抗剂; Siglec 10激动剂如抗Siglec 10抗体; 及其组合。

公开(公告)号：US20100327874A1

公开(公告)日：2010-12-30

申请号：US12822971

申请日：2010-06-24

Applicant: Yang Liu ,  Robert W. Dutton ,  Roger T. Howe

Inventor： Yang Liu ,  Robert W. Dutton ,  Roger T. Howe

IPC: G01N27/62

CPC classification number: G01N33/48721 ,  C12Q1/68 ,  G01N27/04 ,  G01N27/4145 ,  G01N27/44791 ,  G01N33/68

Abstract: According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.

Abstract translation: 根据一个方面，本发明涉及一个示例性实施例，其中基于电路的布置包括基于电路的基板，其沿着基板的表面固定具有不受德拜屏蔽长度限制的有效宽度的通道 。 一对储存器包含在基底中或基底上，并且被配置为容纳和呈现具有用于在通道中递送的生物分子的样品。 一对电极将样品中的电荷电耦合以增强其中的离子电流（例如，以克服电解质屏蔽），并且感测电极沿着通道定位，以通过使用 样品和感应电极的增强的离子电流流动。 通过使用电荷信号处理电路来处理所感测的电荷信号，从而提供指示在通道中递送的生物分子的签名的输出，发生实际检测。

公开(公告)号：US07800746B2

公开(公告)日：2010-09-21

申请号：US11891877

申请日：2007-08-13

Applicant: Vadim Backman ,  Yang Liu ,  Young Kim ,  Hemant Roy ,  Michael Goldberg ,  Randall Brand ,  Prabhakar Pradhan ,  Hariharan Subramanian

Inventor： Vadim Backman ,  Yang Liu ,  Young Kim ,  Hemant Roy ,  Michael Goldberg ,  Randall Brand ,  Prabhakar Pradhan ,  Hariharan Subramanian

IPC: G01N21/41

CPC classification number: G01N21/49 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/4709

Abstract: Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.

Abstract translation: 在本申请中描述了用于识别目标的折射率波动的系统和方法。 一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

公开(公告)号：US07744894B2

公开(公告)日：2010-06-29

申请号：US11129083

申请日：2005-05-13

Applicant: Yang Liu ,  Pan Zheng ,  Xuefeng Bai

Inventor： Yang Liu ,  Pan Zheng ,  Xuefeng Bai

IPC: A61K39/00 ,  A61K39/38

CPC classification number: A61K38/177 ,  A61K38/00 ,  A61K39/0008 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the methods involve administering an HAS/CD24 polypeptide or fragment thereof. In some embodiments, the polypeptide or fragment is glycosylated.

Abstract translation: 提供了阻止哺乳动物中组织的自身反应性T细胞引发的破坏的方法。 在一个实施方案中，所述方法包括施用HAS / CD24多肽或其片段。 在一些实施方案中，多肽或片段被糖基化。

公开(公告)号：US20090254881A1

公开(公告)日：2009-10-08

申请号：US12062826

申请日：2008-04-04

Applicant: Kevin Michael Johnson ,  Robert David Posner ,  Yang Liu

Inventor： Kevin Michael Johnson ,  Robert David Posner ,  Yang Liu

IPC: G06F9/44

CPC classification number: G06F8/30

Abstract: Techniques for using a declarative programming language to automatically generate imperative language computer programs (such as the get, set, enable, and disable commands of the Windows® PowerShell scripting language) that perform administrative tasks of computing environments. A code generator 150 is operative to process a declarative language document, which includes at least three hierarchically-related data structures. The first data structure references certain administrative commands; the second data structure references parameters accepted by the commands; and the third data structure provides pointers to configuration data associated with the parameters. The document is processed in accordance with a set of rules to produce imperative-language execution routines that call sub-routines and pass variables thereto, which enables differences between parameters and configuration data to be mitigated through mapping. At runtime, the sub-routine utilizes a configuration service to retrieve a map of current configuration data from memory, based on values of the variable.

Abstract translation: 使用声明式编程语言自动生成执行计算环境管理任务的命令式语言计算机程序（例如，获取，设置，启用和禁用Windows PowerShell脚本语言的命令）的技术。 代码生成器150用于处理包括至少三个层级相关的数据结构的声明性语言文档。 第一个数据结构引用了某些管理命令; 第二个数据结构引用命令接受的参数; 并且第三数据结构提供指向与参数相关联的配置数据的指针。 该文档根据一组规则进行处理，以产生调用子例程并传递变量的命令式语言执行例程，从而通过映射来减轻参数和配置数据之间的差异。 在运行时，子程序利用配置服务来根据变量的值从存储器检索当前配置数据的映射。

公开(公告)号：US20090063226A1

公开(公告)日：2009-03-05

申请号：US11897651

申请日：2007-08-31

Applicant: Jonny Ray Greiner ,  Yang Liu ,  Bhavin Jagdishbhai Vyas

Inventor： Jonny Ray Greiner ,  Yang Liu ,  Bhavin Jagdishbhai Vyas

IPC: G06Q10/00

CPC classification number: G06Q50/02 ,  G06Q10/047 ,  G06Q10/06 ,  G06Q10/06316 ,  G06Q10/0639 ,  G06Q50/08 ,  G06Q50/30 ,  Y02P90/84

Abstract: A method for managing haul routes in work environments comprises receiving performance criteria associated with a haul route and establishing a target total effective grade for at least one machine associated with the haul route based on the performance criteria. The method also includes collecting performance data associated with the at least one machine. A drive axle torque of the at least one machine is determined and an actual total effective grade associated with the at least one machine is estimated. The at least one machine is identified as an underperforming machine if the actual total effective grade for the at least one machine exceeds the target total effective grade. An average total effective grade for the at least one machine is determined as a function of the actual total effective grade. A haul route deficiency is identified if the average total effective grade exceeds a threshold level.

Abstract translation: 一种用于在工作环境中管理运输路线的方法包括：基于所述性能标准，接收与运输路线相关联的性能标准，并且为与所述运输路线相关联的至少一个机器建立目标总有效等级。 该方法还包括收集与至少一个机器相关联的性能数据。 确定所述至少一个机器的驱动轴扭矩，并且估计与所述至少一个机器相关联的实际总有效等级。 如果至少一台机器的实际总有效等级超过目标总有效等级，则将至少一台机器识别为运行良好的机器。 确定至少一台机器的平均总有效等级作为实际总有效等级的函数。 如果平均总有效等级超过阈值水平，则确定运输路线不足。

公开(公告)号：US20090006540A1

公开(公告)日：2009-01-01

申请号：US11824240

申请日：2007-06-29

Applicant: Yang Liu ,  Larry James Wilson ,  Donald Franklin Smith, JR. ,  William Todd Hasty ,  Todd Philip Cole

Inventor： Yang Liu ,  Larry James Wilson ,  Donald Franklin Smith, JR. ,  William Todd Hasty ,  Todd Philip Cole

IPC: G06F15/16

CPC classification number: H04L67/06 ,  G06F19/00 ,  G07C5/008 ,  G07C5/085 ,  H04L67/125

Abstract: A method for data transfer between a client system and a server comprises receiving one or more user-defined file transfer specifications and establishing a communication channel between a client system and a server system based on the file transfer specifications. The method also includes initializing transfer of operation data between the client system and the server system via the communication channel. The method further includes providing an exception notification to one or more user-designated recipients if the transfer of the operation data between the client system and the server system is inconsistent with the file transfer specifications.

Abstract translation: 一种用于在客户端系统和服务器之间进行数据传输的方法包括：接收一个或多个用户定义的文件传输规范，并根据文件传输规范在客户机系统和服务器系统之间建立通信信道。 该方法还包括通过通信信道初始化客户端系统和服务器系统之间的操作数据的传送。 该方法还包括如果客户端系统与服务器系统之间的操作数据的传送与文件传输规范不一致，则向一个或多个用户指定的接收者提供异常通知。