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    Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content
    3.
    发明申请
    Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content 审中-公开
    使用检测微血管血液含量早期增加来识别异常组织的方法

    公开(公告)号：US20070179368A1

    公开(公告)日：2007-08-02

    申请号：US11604653

    申请日：2006-11-27

    申请人： Vadim Backman ,  Hemant Roy ,  Ramesh Wali ,  Young Kim ,  Michael Siegel ,  Vladimir Turzhitsky

    发明人： Vadim Backman ,  Hemant Roy ,  Ramesh Wali ,  Young Kim ,  Michael Siegel ,  Vladimir Turzhitsky

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0261 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/1459

    摘要： The present invention, in one aspect, relates to a method for examining a target for tumors or lesions using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnormal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.

    摘要翻译： 本发明在一个方面涉及使用所谓的“微血管供血的早期增加”（EIBS）来检查肿瘤或病变的靶标的方法，所述方法存在于接近但不是本身的组织中 ，异常组织和在这些损伤或肿瘤的发展之前的组织中。 虽然异常组织可以是病变或肿瘤，但是异常组织也可以是在形成病变或肿瘤之前的组织，例如癌前腺瘤，异常隐窝灶，在发育不良的病变之前的组织，其本身还没有 表现出发育不良的表型，以及这些损伤或发育不良前组织附近的组织。

    Antisense composition and method for treating cancer
    4.
    发明申请
    Antisense composition and method for treating cancer 失效
    反义成分和治疗癌症的方法

    公开(公告)号：US20050261249A1

    公开(公告)日：2005-11-24

    申请号：US11077871

    申请日：2005-03-10

    申请人： Patrick Iversen ,  Hemant Roy ,  Richard Bestwick

    发明人： Patrick Iversen ,  Hemant Roy ,  Richard Bestwick

    IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/85

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  C12N15/113 ,  C12N15/8509 ,  C12N2310/11 ,  C12N2310/3145 ,  C12N2310/3233

    摘要： A method and composition for of treating cancer, and in particular, for arresting the progression of a solid or primary cancer to a more invasive, metastatic state, are disclosed. The composition includes a substantially uncharged antisense compound (i) having a nuclease-resistant backbone, (ii) capable of uptake by target cancer cells in the subject, (iii) containing between 10-40 nucleotide bases, and (iv) having a base sequence effective to hybridize to a region of processed or preprocessed human SNAIL RNA transcript. The compound, when administered to the subject, is effective to form within target cancer cells in the subject, a base-paired heteroduplex structure composed of human SNAIL RNA transcript and the oligonucleotide compound, where this structure is characterized by a Tm of dissociation of at least 45° C. The compound is administered in an amount sufficient to inhibit SNAIL expression in target cancer cells, thereby to inhibit the progression of the patient's cancer to a more invasive, metastatic state. Also disclosed are methods for preventing the transdifferentiation of peritoneal mesothelial cells and failure of ultrafiltration in a patient undergoing peritoneal dialysis, by including the compound in the patient dialysis fluid.

    摘要翻译： 公开了用于治疗癌症的方法和组合物，特别是用于将固体或原发癌的进展阻止到更具侵袭性的转移状态。 组合物包括具有核酸酶抗性骨架的基本上不带电的反义化合物（i），（ii）能够被摄体中靶细胞摄取的能力，（iii）含有10-40个核苷酸碱基和（iv）具有碱基 有效地与经处理或预处理的人SNAIL RNA转录物区域杂交的序列。 该化合物当被施用于受试者时，在受试者的靶癌细胞内形成，由人SNAIL RNA转录物和寡核苷酸化合物组成的碱基配对的异源双链结构是有效的，其中该结构的特征在于解离的Tm 至少45℃。化合物以足以抑制靶癌细胞中SNAIL表达的量施用，从而抑制患者癌症进展到更具侵袭性的转移状态。 还公开了通过将化合物包括在患者透析液中来防止腹膜间皮细胞的转分化和经历腹膜透析的患者中的超滤失败的方法。

    Method for identifying refractive-index fluctuations of a target
    6.
    发明授权
    Method for identifying refractive-index fluctuations of a target 有权
    用于识别目标的折射率波动的方法

    公开(公告)号：US07800746B2

    公开(公告)日：2010-09-21

    申请号：US11891877

    申请日：2007-08-13

    申请人： Vadim Backman ,  Yang Liu ,  Young Kim ,  Hemant Roy ,  Michael Goldberg ,  Randall Brand ,  Prabhakar Pradhan ,  Hariharan Subramanian

    发明人： Vadim Backman ,  Yang Liu ,  Young Kim ,  Hemant Roy ,  Michael Goldberg ,  Randall Brand ,  Prabhakar Pradhan ,  Hariharan Subramanian

    IPC分类号： G01N21/41

    CPC分类号： G01N21/49 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/4709

    摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.

    摘要翻译： 在本申请中描述了用于识别目标的折射率波动的系统和方法。 一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

    METHOD OF SCREENING FOR CANCER USING PARAMETERS OBTAINED BY THE DETECTION OF EARLY INCREASE IN MICROVASCULAR BLOOD CONTENT
    7.
    发明申请
    METHOD OF SCREENING FOR CANCER USING PARAMETERS OBTAINED BY THE DETECTION OF EARLY INCREASE IN MICROVASCULAR BLOOD CONTENT 审中-公开
    通过检测微血管内容物中早期检测获得的参数来筛选癌症的方法

    公开(公告)号：US20090203977A1

    公开(公告)日：2009-08-13

    申请号：US12350955

    申请日：2009-01-08

    申请人： Vadim Backman ,  Hemant Roy ,  Andrew Gomes ,  Sarah Ruderman ,  Jeremy Rogers

    发明人： Vadim Backman ,  Hemant Roy ,  Andrew Gomes ,  Sarah Ruderman ,  Jeremy Rogers

    IPC分类号： A61B5/1459

    CPC分类号： A61B5/4255 ,  A61B1/31 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0261 ,  A61B5/1459 ,  A61B2560/0443 ,  A61B2562/0242

    摘要： The present invention, in one aspect, relates to screening test for tumors or lesions using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnormal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.

    摘要翻译： 本发明在一个方面涉及使用所谓的“微血管供血的早期增加”（EIBS）来筛选肿瘤或病变的试验，其存在于接近但本身不属于异常组织的组织中 和在这种损伤或肿瘤的发展之前的组织中。 虽然异常组织可以是病变或肿瘤，但是异常组织也可以是在形成病变或肿瘤之前的组织，例如癌前腺瘤，异常隐窝灶，在发育不良的病变之前的组织，其本身还没有 表现出发育不良的表型，以及这些损伤或发育不良前组织附近的组织。

    Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content
    8.
    发明申请
    Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content 审中-公开
    使用检测微血管血液含量的早期增加识别异常组织的装置

    公开(公告)号：US20070129615A1

    公开(公告)日：2007-06-07

    申请号：US11604659

    申请日：2006-11-27

    申请人： Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu

    发明人： Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0261 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/1459 ,  A61B2560/0443 ,  A61B2562/0242 ,  G01N33/48

    摘要： The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for a depth range detection selectivity for detection of blood within microvasculature of tissue is described.

    摘要翻译： 本发明涉及用于利用检测到的微血管血液供应的早期增加和相应应用来识别可能的异常活体组织的探针装置及其组分组合。 在一个实施例中，公开了一种将从光源发射的宽带光发射到设置在人体内的组织的微血管上的装置，并且接收从宽带光与微血管系统的相互作用获得的相互作用的光，以便传输到接收器。 不同的另外的实施例包括有助于选择相互作用的光的预定深度分布的光纤，偏振器和透镜的组合。 在另一个实施例中，描述了具有各种探针尖端和/或光透射元件的套件装置，其提供了相互作用的光的预定深度分布的各种组合。 在另一个实施方案中，描述了制备用于检测组织微血管内的血液的深度范围检测选择性的光谱数据探针的方法。

    Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy
    9.
    发明授权
    Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy 有权
    低相干增强后向散射光谱的系统，方法和装置

    公开(公告)号：US07652772B2

    公开(公告)日：2010-01-26

    申请号：US11803029

    申请日：2007-05-11

    申请人： Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu ,  Vladimir Turzhitsky ,  Jeremy Rogers

    发明人： Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu ,  Vladimir Turzhitsky ,  Jeremy Rogers

    IPC分类号： G01B9/02

    CPC分类号： G01J3/4412 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/10 ,  G01N21/31 ,  G01N21/47 ,  G01N2021/4709

    摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.

    摘要翻译： 本申请中描述了低相干增强后向散射光谱的系统，方法和装置。 一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。 记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角 是入射光传播方向和反向散射光传播方向之间的角度。 分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。