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131 条记录 (耗时 0.013 秒)

    Aminophenylamidines, their production and their pharmaceutical use
    122.
    发明授权
    Aminophenylamidines, their production and their pharmaceutical use 失效
    氨基苯基脒，其生产及其药用

    公开(公告)号：US3911010A

    公开(公告)日：1975-10-07

    申请号：US39869273

    申请日：1973-09-19

    申请人： BAYER AG

    发明人： WOLLWEBER HARTMUND ,  FLUCKE WINFRIED

    IPC分类号： C07C259/14 ,  C07D209/42 ,  C07C123/00

    CPC分类号： C07C259/14 ,  C07D209/42

    摘要： The present invention relates to new aminophenylamidines, to processes for their production, and to their pharmaceutical use. These new compounds are useful as paraciticides, especially as anthelmintics. Some acylaminophenylformamidines, such as N-(p-acetamidophenyl)N'',N''-dimethylformamidine (U.S. Pat. No. 3,184,482) and N-phenylacetamidines, such as N-(p-chlorophenyl)-N'',N''dimethylacetamidine, are already known. These compounds are however inactive against the helminths mentioned below.

    摘要翻译： 本发明涉及新的氨基苯基脒，其制备方法及其药物用途。 这些新化合物可用作杀螨剂，特别是作为驱肠虫剂。

    Chlorinated mandelamidines
    123.
    发明授权
    Chlorinated mandelamidines 失效
    氯化扁桃酰脒

    公开(公告)号：US3899533A

    公开(公告)日：1975-08-12

    申请号：US41777273

    申请日：1973-11-21

    申请人： ORSYMONDE

    发明人： SOUCHARD MADDY

    IPC分类号： C07C67/00 ,  C07C239/00 ,  C07C257/14 ,  C07C259/14 ,  C07D213/79 ,  C07D233/22 ,  C07D239/06 ,  C07C123/00

    CPC分类号： C07D239/06 ,  C07C259/14 ,  C07D233/22

    摘要： New chlorinated derivatives of mandelamidine and acid addition salts thereof are produced by reacting a mandeliminoalkyl ether of the formula

    in which A is alkyl lower alkyl group, preferably C1-C2, and X, Y, Z represent H or Cl, one at least of the X, Y and Z being a chlorine atom, or one of the acid addition salts of the said mandeliminoalkyl ether, preferably the hydrochloride, with an amine of the formula

    摘要翻译： 通过使式NH CHOH-C ANGLE OA的烷基亚氨基烷基醚（其中A是烷基低级烷基，优选C 1 -C 2）与X，Y，Z表示H或Cl 至少X，Y和Z中的至少一个为氯原子，或所述扁桃酰烷基醚，优选盐酸盐的酸加成盐之一与式HNR1R'2的胺，其中R1如上定义， R'2表示氢原子，C1-C5低级烷基，NH2基，OH基，R'2可以是（CH2）nNH2基，其中n是2的整数 或当R1 = H时为3，如果需要，当R2不同于OH时，由此获得的产物进行用于引入基团R =酰基的酯化反应。 这些新衍生物特别适用于治疗高血压。

    {107 -(3-Hydroxyphenyl)substituted amidines and derivatives thereof as anthelmintic agents
    124.
    发明授权
    {107 -(3-Hydroxyphenyl)substituted amidines and derivatives thereof as anthelmintic agents 失效
    {107-（3-羟基苯基）取代的脒及其衍生物作为驱肠剂

    公开(公告)号：US3891698A

    公开(公告)日：1975-06-24

    申请号：US7577670

    申请日：1970-09-25

    申请人： PFIZER

    发明人： MCFARLAND JAMES W

    IPC分类号： C07C59/52 ,  C07C65/03 ,  C07C259/14 ,  C07D233/22 ,  C07D233/24 ,  C07D239/06 ,  C07C123/00

    CPC分类号： C07D239/06 ,  C07C59/52 ,  C07C65/03 ,  C07C259/14 ,  C07D233/22 ,  C07D233/24

    摘要： The preparation and anthelmintic properties of certain omega (3-R-O-phenyl) substituted cyclic and acyclic amidines; namely, 1,4,5,6-tetrahydro-2-(2-(3-R-O-phenyl)ethyl)pyrimidines, 1,4,5,6tetrahydro-2-(2-(3-R-O-phenyl)vinyl)pyrimidines and the corresponding 2-imidazolines; and N-methyl-N-substituted 3-(3-RO-phenyl) propionamidines and the corresponding acrylamidines wherein R-O- is hydroxy or a group convertible to hydroxy, is described.

    摘要翻译： 某些ω-（3-R-O-苯基）取代的环状和非环状脒的制备和驱虫特性; 即1,4,5,6-四氢-2- [2-（3-RO-苯基）乙基]嘧啶，1,4,5,6-四氢-2- [2-（3-RO-苯基） 乙烯基]嘧啶和相应的2-咪唑啉; 和N-甲基-N-取代的3-（3-R-O-苯基）丙酰胺和其中R-O-是羟基或可转化成羟基的基团的相应的丙烯酰胺。

    Substituted phenylthioamidines
    127.
    发明授权
    Substituted phenylthioamidines 失效
    取代的苯乙胺

    公开(公告)号：US3775478A

    公开(公告)日：1973-11-27

    申请号：US3775478D

    申请日：1972-05-30

    申请人： DOW CHEMICAL CO

    发明人： BOCKSTAHLER E

    IPC分类号： C07C259/14 ,  C07C123/00

    CPC分类号： C07C259/14

    摘要： SUBSTITUTED PHENYLTHIOAMIDE COMPOUNDS SUCH AS 2-(4CHLOROPHENYLTHIO)ACETAMIDINE; 2-(4 - RHLOROPHENYLTHIO)ACETAMIDOXIME; AND THEIR PHARAMACEUTICALLY-ACCEPTABLE SALTS ARE PREPARED BY THE REACTION OF A SUBSTITUTED PHENYLTHIOACETONITRILE WITH HYDROXYLAMINE HYDROCHLORIDE OR WITH METHANOL FOLLOWED BY AMMONIUM CHLORIDE. THE COMPOUNDS HAVE ANTIMICROBIAL ACTIVITY AND ALSO INHIBIT ADPINDUCED AGGREGATION OF BLOOD PLATELETS.