公开(公告)号：US4160452A

公开(公告)日：1979-07-10

申请号：US785582

申请日：1977-04-07

Applicant: Felix Theeuwes

Inventor： Felix Theeuwes

IPC: A01N25/34 ,  A23P1/02 ,  A61F9/00 ,  A61K8/00 ,  A61K8/20 ,  A61K8/23 ,  A61K8/42 ,  A61K8/49 ,  A61K9/00 ,  A61K9/22 ,  A61Q90/00 ,  B01J4/04 ,  A61M31/00

CPC classification number: A61F9/0017 ,  A61K9/0004

Abstract: An osmotic therapeutic system for delivering a beneficial drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in laminar arrangement with a microporous lamina to provide a wall that is permeable to an external fluid, impermeable to drug and maintains its integrity during the delivery of drug. The reservoir contains a drug, or a mixture of drug and solute which drug or solute is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, drug is released from the system by fluid being imbibed through the wall into the reservoir at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall thereby producing a solution of drug, or a solution of solute containing drug which solution is released through the portal at a controlled rate over a prolonged period of time.

Abstract translation: 公开了用于递送有益药物的渗透性治疗系统。 该系统包括药物递送模块，该模块包括围绕储存器的速率控制层压壁，并具有用于从系统输送药物的入口。 层压壁包括层状布置的微透膜，其具有微孔层，以提供对外部流体是可渗透的壁，在药物递送期间不可渗透并保持其完整性。 储存器包含药物或药物和溶质的混合物，其药物或溶质可溶于流体中并且表现出跨越壁的渗透压梯度抵抗流体。 在操作中，通过流体通过壁被吸入到储存器中的药物通过由壁的渗透性和穿过壁的渗透压梯度确定的速率从体系释放，由此产生药物溶液或含有 该药物在长时间内以受控的速率通过门静脉释放。

公开(公告)号：US4111202A

公开(公告)日：1978-09-05

申请号：US743975

申请日：1976-11-22

Applicant: Felix Theeuwes

Inventor： Felix Theeuwes

IPC: A01N25/34 ,  A01N25/00 ,  A23P1/00 ,  A61K8/00 ,  A61K9/00 ,  A61Q90/00 ,  B01J4/04 ,  B65D25/04 ,  A61M31/00

CPC classification number: A61K9/0004 ,  A61K9/0036

Abstract: An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding an agent compartment and an osmagent compartment separated by a film and has a passageway through the wall for delivering agent from its compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent and osmagent. The film is formed of a material impermeable to the passage of agent and osmagent and movable from an original to an expanded state. The agent compartment contains an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the compartment contains an agent that has limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against fluid. The osmagent compartment contains an osmagent that exhibits an osmotic pressure gradient across the wall against the fluid. In operation, agent is delivered from the system through the passageway by fluid being imbibed through the wall into the osmagent compartment urging it to increase in volume and expand the film and correspondingly diminishing the volume of the agent compartment, whereby agent is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the expansion of the film over a prolonged period of time.

公开(公告)号：US4034756A

公开(公告)日：1977-07-12

申请号：US666365

申请日：1976-03-12

Applicant: Takeru Higuchi ,  Harold M. Leeper

Inventor： Takeru Higuchi ,  Harold M. Leeper

IPC: A01G7/06 ,  A61D7/00 ,  A61K9/00 ,  B01J4/04 ,  B65D1/04 ,  A61M5/00 ,  A61F5/46 ,  A61M31/00

CPC classification number: B01J4/04 ,  A01G7/06 ,  A61D7/00 ,  A61K9/0004 ,  B65D1/04

Abstract: An osmotically driven fluid dispenser for use in an aqueous environment comprising: a shape retaining canister having controlled permeability to water; an osmotically effective solute confined in the canister which, in solution, exhibits an osmotic pressure gradient against the water in the environment; an outlet in the canister wall; and a flexible bag of relatively impervious material that holds the fluid to be dispensed and is housed in the canister with its open end in sealed contact with the canister such that the canister outlet communicates with the bag interior and the bag interior is closed to the solute and aqueous solution thereof with the remainder of the bag spaced from and generally unsupported by the canister wall.

Abstract translation: 一种用于水性环境的渗透驱动的流体分配器，包括：具有受控的水渗透性的形状保持罐; 限制在罐中的渗透有效溶质，其在溶液中表现出对环境中的水的渗透压梯度; 罐壁上的出口; 以及保持要分配的流体的相对不透水材料的柔性袋，并且其容纳在罐中，其开口端与罐密封接触，使得罐出口与袋内部连通并且袋内部关闭到溶质 其水溶液与袋的其余部分间隔开并且通常不被罐壁支撑。

公开(公告)号：US4027045A

公开(公告)日：1977-05-31

申请号：US546982

申请日：1975-02-03

Applicant: Igor Mikhailovich Fedotkin ,  Anatoly Konstantinovich Jukhimets ,  Leonid Panteleimonovich Odery

Inventor： Igor Mikhailovich Fedotkin ,  Anatoly Konstantinovich Jukhimets ,  Leonid Panteleimonovich Odery

IPC: A23C21/00 ,  A23P30/40 ,  B01F3/04 ,  B01J4/04 ,  C12H1/14 ,  C02D1/02

CPC classification number: C12H1/14 ,  A23C21/00 ,  A23P30/40 ,  B01F3/04262 ,  B01F3/04446 ,  B01J4/04 ,  B01F2003/04312 ,  B01F2003/0439 ,  Y10S261/26

Abstract: According to the proposed process for preparing oxygenated cocktail, dispersed oxygen is continuously introduced into a continuously supplied thin (not in excess of 5 mm) layer of a foam-forming food liquid over the entire volume of said liquid. The disclosed apparatus for effecting said process comprises a vessel with a porous member arranged therein, which divides said vessel into two sealed off portions. The lower portion permanently communicates via a branch pipe with a forced oxygen supply source, whereas the upper portion serves as a container for the foam-forming liquid for preparing oxygenated cocktail and has a pipe for the supply of said food foam-forming liquid and a pipe for discharging prepared cocktail. The foam-forming food liquid may be fruit juice, kvass, beer, whey, buttermilk, herb infusion and other biologically adequate liquid products.

Abstract translation: 根据所提出的含氧混合物的制备方法，将分散的氧在所述液体的整个体积上连续引入连续供应的泡沫形成食品液体的薄（不超过5mm）层。 用于实现所述方法的所公开的装置包括其中布置有多孔构件的容器，其将所述容器分成两个密封的部分。 下部通过分支管与强制氧供应源永久地连通，而上部用作用于制备含氧混合物的泡沫形成液体的容器，并且具有用于供应所述食品泡沫形成液体的管和 用于排放准备好的鸡尾酒的管子。 泡沫形成食品液体可以是果汁，kvass，啤酒，乳清，酪乳，药草输注等生物学上足够的液体产品。

公开(公告)号：US3995632A

公开(公告)日：1976-12-07

申请号：US510753

申请日：1974-09-30

Applicant: Masahiro Nakano ,  Takeru Higuchi ,  Anwar Hussain

Inventor： Masahiro Nakano ,  Takeru Higuchi ,  Anwar Hussain

IPC: A61K9/00 ,  B01J4/04 ,  A61M31/00

CPC classification number: B01J4/04 ,  A61K9/0004

Abstract: An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the active agent formulation of which is a solid or semisolid at storage temperatures, advantageously room temperature, and is fluid at the temperature of the prospective situs for the osmotic dispenser, typically at body temperature.

Abstract translation: 描述了一种渗透分配器，其能够在更长的时间内以渗透控制的速率释放其外部环境浓度的活性剂，并且其活性剂配方在储存温度，有利于室温下为固体或半固体， 并且在渗透分配器的预期位置的温度下是流体，通常在体温下。

公开(公告)号：US3760805A

公开(公告)日：1973-09-25

申请号：US3760805D

申请日：1971-01-13

Applicant: ALZA CORP

Inventor： HIGUCHI T

IPC: A01G7/06 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  B01J4/04 ,  B65D1/04 ,  A61M31/00

CPC classification number: A01G7/06 ,  A61D7/00 ,  A61K9/0004 ,  B01J4/04 ,  B65D1/04

Abstract: An osmotic dispenser is comprised of (1) a water porous housing member confining (2) a first flexible bag of relatively impervious material containing an active agent and provided with active agent dispensing head, and (3) a second bag of controlled permeability to moisture containing a solution which exhibits an osmotic pressure gradient against water. The first and second bags are disposed within the housing member such that water permeates from the external environment through the housing and migrates by osmosis into the solution contained in the second bag which increases in volume thereby generating mechanical force on the first bag, which mechanical force in turn ejects the active agent out of the apparatus.

Abstract translation: 渗透分配器包括（1）水多孔壳体构件，其限定（2）包含活性剂并具有活性剂分配头的相对不透水材料的第一柔性袋，以及（3）第二袋， 含有对水表现出渗透压梯度的溶液。 第一袋和第二袋设置在壳体构件内，使得水从外部环境通过壳体渗透并通过渗透迁移到容纳在第二袋中的溶液中，从而在第一袋上产生机械力，该机械力 反过来将活性剂排出设备。

公开(公告)号：US3603509A

公开(公告)日：1971-09-07

申请号：US3603509D

申请日：1970-02-24

Applicant: FMC CORP

Inventor： NECHINE LEONARD M

IPC: B01F3/04 ,  B01J4/04 ,  C02F3/20 ,  C12M1/04 ,  B01D47/02

CPC classification number: C02F3/20 ,  B01F3/04269 ,  B01F2003/04319 ,  B01F2003/04382 ,  B01J4/04 ,  C12M29/06 ,  Y02W10/15

Abstract: An apparatus for dispersing gas in liquid mediums comprising a rigid adapter, a rigid tubular inner member secured to the adapter cooperating with a passage in said adapter to form a continuous conduit for gas, a terminal member for said rigid tubular inner member, a flexible, collapsible porous sleeve, having one permanently closed end and a peripheral dimension approximately equal to the peripheral dimension of a cross section of said tubular member, enclosing said tubular member and said terminal member and secured to the adapter to form an air chamber between the tubular member and the sleeve, said terminal member having means for passage of gas between the interior of the tubular member and the closed end of said sleeve and separate communication means connecting the closed end of said sleeve and the longitudinally extending space between the sleeve and said tubular member.

公开(公告)号：US2570435A

公开(公告)日：1951-10-09

申请号：US58576345

申请日：1945-03-30

Applicant: DOWNING FREDERICK B ,  ROBERTS JOHN B

Inventor： DOWNING FREDERICK B ,  ROBERTS JOHN B

IPC: B01J4/04 ,  B01J12/00

CPC classification number: B01J4/04 ,  B01J12/007