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131.发明公开公开(公告)号：US20240011019A1
公开(公告)日：2024-01-11
申请号：US18348201
申请日：2023-07-06
Inventor： Joshua LaBaer
CPC classification number: C12N15/1062 , G01N33/6845 , G01N33/6854 , G01N2458/10
Abstract: Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.
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公开(公告)号：US20240002878A1
公开(公告)日：2024-01-04
申请号：US18327373
申请日：2023-06-01
Inventor： Samira Kiani , Mo Reza Ebrahimkhani , Jennifer Chapman
IPC: C12N15/85 , C12N9/22 , C12N15/11 , C12N15/115 , C12N15/62
CPC classification number: C12N15/85 , C12N9/22 , C12N15/11 , C12N15/115 , C12N15/62 , C12N2310/20 , C12N2800/80 , C12N15/907
Abstract: Aspects of the disclosure relate to methods and synthetic regulatory systems for more efficient nuclease-mediated homology-directed repair (HDR). In particular, provided herein are methods for more efficient in vivo and in vitro HDR-based gene editing where the methods comprise introducing into a cell a synthetic regulatory system comprising Cas nuclease, guide RNAs (gRNAs) having various lengths and configured to target distinct nucleotide sequences for simultaneous transcriptional repression (or activation) and genome editing via double stranded break and use of a donor nucleic acid molecule as a template for repair.
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公开(公告)号：US20240002457A1
公开(公告)日：2024-01-04
申请号：US18037098
申请日：2021-11-16
IPC: C07K14/435 , A23K20/147 , A23K20/189 , A23K50/80 , C12N9/16 , C12N9/48 , C12Q1/6883
CPC classification number: C07K14/43509 , A23K20/147 , A23K20/189 , A61K38/00 , C12N9/16 , C12N9/485 , C12Q1/6883 , A23K50/80
Abstract: Described herein are proteins and fragments thereof that can be capable of binding or otherwise interacting with a Vibrio species toxin. The Vibrio toxin binding proteins and fragments thereof can be included in a formulation, such as a feed formulation, that can be used to treat and/or prevent Vibrio spp. disease or a symptom thereof, such as AHPND. Also described herein are AHPND susceptibility signatures that can be useful for identification of susceptible and/or resistant/tolerant organisms.
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公开(公告)号：US20240002437A1
公开(公告)日：2024-01-04
申请号：US18251078
申请日：2021-10-25
Inventor： Stephen M. Black , Evgeny A. Zemskov , Qing Lu
CPC classification number: C07K5/1021 , A61P11/00 , A61K38/00
Abstract: It has been discovered that phosphorylation-dependent uncoupling of endothelial nitric oxide synthase (eNOS) plays an important role in endothelial cell (EC) barrier disruption. Compositions and methods to reduce or prevent eNOS uncoupling are disclosed. Decoy peptides that can prevent phosphorylation and mitochondrial redistribution of eNOS, reduce eNOS uncoupling, and preserve EC barrier function, and uses thereof, are described. The peptides improve lung vascular integrity in a mouse model of VILI. Thus, the decoy peptides can be used to treat or prevent diseases or disorders associated with increased vascular permeability such as ALI, ARDS, and VILI.
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公开(公告)号：US20230414655A1
公开(公告)日：2023-12-28
申请号：US18209618
申请日：2023-06-14
Inventor： Vance G. Nielsen
Abstract: This invention relates to compositions and methods for treating, ameliorating, and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising one or more ruthenim based-agents for one or more of inhibiting venom related procoagulant activity, inhibiting venom related phospholipase A2 (PLA2), and/or inhibiting venom related thrombus generation, and related methods for treating, ameliorating and preventing the toxic effects of venom poisoning in a subject suffering from or at risk of suffering from venom poisoning.
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Patent Agency Ranking
公开(公告)号：US20230408409A1
公开(公告)日：2023-12-21
申请号：US18204735
申请日：2023-06-01
Inventor： Shaopeng WANG , Pengfei ZHANG
IPC: G01N21/55 , G01N33/543 , G16B15/00
CPC classification number: G01N21/55 , G01N33/54373 , G16B15/00 , G01N2021/556
Abstract: Provided herein are methods of detecting exosomes, including unlabeled exosomes. In some embodiments, the methods include disposing a fluidic sample that comprises a plurality of exosomes in a chamber that is positioned at least partially within a fluidic device in which an inner surface of the chamber comprises a first set of exosome binding moieties that are capable of binding the exosomes. In some embodiments, the methods also include binding a portion of the plurality of exosomes to a portion of the first set of exosome binding moieties to produce surface-bound exosomes, introducing an incident light toward the inner surface of the chamber prior to, concurrent with, and/or after, producing the surface-bound exosomes, and detecting light scattered by the surface-bound exosomes to produce a set of exosome imaging data. Related fluidic devices, systems, and computer readable media are also provided.
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公开(公告)号：US20230405130A1
公开(公告)日：2023-12-21
申请号：US18035573
申请日：2021-11-05
Applicant: Arizona Board of Regents on Behalf of the University of Arizona , The Penn State Research Foundation
Inventor： David B. Stewart , Gayatri Vedantam , Arun K. Sharma , Jacek KRZEMINSKI
IPC: A61K47/54 , C12N15/113 , A61K31/713
CPC classification number: A61K47/545 , C12N15/113 , A61K31/713 , C12N2310/11 , C12N2320/32 , C12Y207/07007
Abstract: Provided herein are compositions and methods for treating and preventing bacterial infections. In particular, provided herein are targeted bola-amphiphile: nucleic acid complexes specific for bacteria.
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公开(公告)号：US11846828B2
公开(公告)日：2023-12-19
申请号：US16969547
申请日：2019-02-08
Inventor： Laird M. Close , Maggie Y. Kautz
CPC classification number: G02B7/1825 , F16B2/065 , G02B7/181
Abstract: A stabilizing locking clamp for a kinematic optical mount includes a clamp plate configured for optical access and a plurality of clamp actuators affixed to the clamp plate. The clamp actuators are positioned such that each clamp actuator exerts a force on a front plate of the kinematic optical mount in a push-push configuration. A stabilizing kinematic optical mount includes a kinematic optical mount and a plurality of clamp arms, each clamp arm including a clamp actuator positioned to exert a force on a front plate of the kinematic optical mount in a push-push configuration. The stabilizing locking clamp and stabilizing kinematic optical mount reduce temperature-dependent and vibration-induced changes in pitch and yaw, thereby improving pointing stability for optical setups that rely on critical beam alignment.
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公开(公告)号：US11846032B2
公开(公告)日：2023-12-19
申请号：US16771597
申请日：2018-12-11
Inventor： Dennis Lichtenberger , Richard S. Glass , Dong-Chul Pyun , William Brezinski , Kayla Clary , Metin Karayilan
Abstract: Catalyst systems employing inexpensive and readily-available protic co-catalysts to increase a proton reduction rate in a hydrogen evolution reaction (HER) are described herein. The protic co-catalysts function to increase the rate without being consumed in the process of water splitting to hydrogen and oxygen. They may simultaneously serve to stabilize the pH of the water and be the electrolyte to carry the current for the electrolytic splitting of water. The protic co-catalysts also decrease the overpotential energy requirement for the process of water splitting. These protic co-catalysts can be used with both heterogeneous and homogenous catalysts, as well as assist photocatalysis and other processes for the reduction of protons.
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公开(公告)号：US20230401452A1
公开(公告)日：2023-12-14
申请号：US18335080
申请日：2023-06-14
Inventor： Rida Bazzi , Om Thakkar
IPC: G06N3/0985 , G06N3/098
CPC classification number: G06N3/0985 , G06N3/098
Abstract: Systems and methods herein train weight-agnostic networks in a federated learning setting with orthogonal data distribution. Unlike traditional networks, weight-agnostic networks have a small size and can be trained using neural architecture search. The methods and systems described herein include sharing of a subset of networks between clients to allow federated learning for weight-agnostic networks in which clients do not have samples from all classes.
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