公开(公告)号：US12085786B2

公开(公告)日：2024-09-10

申请号：US18314996

申请日：2023-05-10

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi ,  Ryo Kubota

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

CPC classification number: G02C7/04 ,  G02B27/017 ,  G02C7/14 ,  G02B2027/0178 ,  G02C2202/24

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US20240252835A1

公开(公告)日：2024-08-01

申请号：US18632487

申请日：2024-04-11

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11974807B2

公开(公告)日：2024-05-07

申请号：US18040186

申请日：2021-08-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Cyril Stoller

IPC: A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

公开(公告)号：US20240108216A1

公开(公告)日：2024-04-04

申请号：US18525549

申请日：2023-11-30

Applicant: ACUCELA INC.

Inventor： Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/10 ,  A61B3/1005 ,  A61B3/1225 ,  A61B5/0013 ,  G01B9/02 ,  A61B2505/07 ,  A61B2560/0425 ,  A61B2560/0431 ,  A61B2560/0456 ,  A61B2576/00

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20230363640A1

公开(公告)日：2023-11-16

申请号：US18317549

申请日：2023-05-15

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Stephan WYDER ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Alexander HOLZER

IPC: A61B3/10 ,  G01B9/02004 ,  G01B9/02091 ,  A61B3/12

CPC classification number: A61B3/102 ,  G01B9/02004 ,  G01B9/02091 ,  A61B3/1225

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

公开(公告)号：US11798164B2

公开(公告)日：2023-10-24

申请号：US18177560

申请日：2023-03-02

Applicant: ACUCELA INC.

Inventor： Stephan Wyder ,  Matthias Pfister ,  Cyril Stoller ,  Philip M. Buscemi

IPC: G06T7/00 ,  G06T7/11 ,  G06T3/00 ,  G06V10/82 ,  G06N3/08 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06N3/08 ,  G06T3/00 ,  G06T7/11 ,  G16H30/40 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30041 ,  G06V10/82 ,  G06V2201/03

Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

公开(公告)号：US11787791B2

公开(公告)日：2023-10-17

申请号：US17279382

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. Orme ,  Edison S. Zuniga ,  Vladimir A. Kuksa ,  Russell Stuart Craft ,  Eduardo Moreno Saveedra ,  Johannes Wilhelm Georg Meissner ,  Jacobus Antonius Joseph den Hartog ,  Albert Cornelis Dros

IPC: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US11777340B2

公开(公告)日：2023-10-03

申请号：US17904450

申请日：2021-02-19

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Patrizia Weber ,  Marco Burgener ,  Jonas Butscher ,  Praveenth Sanmugarajah ,  Hans Bernhard ,  Amitava Gupta

IPC: H02J50/10 ,  H02J50/40 ,  A45C11/00 ,  A45C15/00 ,  G02C7/04 ,  G02C11/00 ,  H02J7/00

CPC classification number: H02J50/10 ,  A45C11/005 ,  A45C15/00 ,  G02C7/04 ,  G02C11/10 ,  H02J7/0013 ,  H02J7/0044 ,  H02J50/40

Abstract: A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.

公开(公告)号：US20230284897A1

公开(公告)日：2023-09-14

申请号：US18005888

申请日：2021-09-30

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/103 ,  A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B3/135

CPC classification number: A61B3/103 ,  A61B3/14 ,  A61B3/0025 ,  A61B3/1015 ,  A61B3/135 ,  A61B3/102

Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.

公开(公告)号：US11730363B2

公开(公告)日：2023-08-22

申请号：US17757748

申请日：2020-09-02

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/0075 ,  A61B3/0091 ,  A61B3/1005 ,  A61B3/12

Abstract: Improved optical coherence tomography systems and methods to measure retinal data are presented. The systems may be compact, provide in-home monitoring, and have automation to allow the patient to measure himself or herself.