公开(公告)号：US20190308932A1

公开(公告)日：2019-10-10

申请号：US16340458

申请日：2017-10-13

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Chung-Jen James CHOU ,  Jesse McClure ,  Cheng ZHANG ,  Elizabeth INKS

IPC: C07C243/38 ,  C07D307/85 ,  C07D213/87 ,  C07D333/38 ,  C07D307/68 ,  C07C243/26 ,  A61P35/02

Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of cancer.

公开(公告)号：US20190274785A1

公开(公告)日：2019-09-12

申请号：US16299292

申请日：2019-03-12

Applicant: MUSC Foundation for Research Development

Inventor： Walter Renne ,  Zachary Evans

IPC: A61C1/08 ,  A61C8/00 ,  A61C9/00 ,  A61B17/17

Abstract: Provided herein are surgical guides with internal channels for irrigation cooling. In one embodiment, an apparatus for guiding a surgical instrument includes a proximal side and a distal side. A first channel is configured to guide a material removal device, where the first channel extends from the proximal side of the apparatus to the distal side of the apparatus. A second channel configured to direct irrigation fluid, where the second channel extends from the proximal side of the of the apparatus to the distal side of the apparatus. The first channel is separate from the second channel. A method of performing a surgical procedure and a method of manufacturing a surgical guide are also disclosed. In certain embodiments, the surgical guides may be manufactured via additive manufacturing processes, including for example, three-dimensional printing processes.

公开(公告)号：US20190247478A1

公开(公告)日：2019-08-15

申请号：US16342853

申请日：2017-10-17

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Stephen TOMLINSON ,  DeAnna ADKINS ,  Ali ALAWIEH

IPC: A61K38/57 ,  A61K38/17 ,  A61P25/00 ,  C07K16/18

CPC classification number: A61K38/57 ,  A61K38/1709 ,  A61K38/1725 ,  A61K38/49 ,  A61K2039/505 ,  A61P25/00 ,  C07K16/18 ,  C07K2317/622 ,  A61K2300/00

Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.

公开(公告)号：US10344071B2

公开(公告)日：2019-07-09

申请号：US15747805

申请日：2016-07-21

Applicant: MUSC Foundation for Research Development

Inventor： Galina S. Bogatkevich ,  Yuichiro Shirai ,  Richard M. Silver

IPC: C07K14/705 ,  A61K45/06 ,  C07K14/71 ,  A61P17/00 ,  A61K38/17 ,  A61K38/00

Abstract: The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides, host cells transformed with the polynucleotides, and methods of using these peptides and polynucleotides are included in the invention. Uses of these peptides, polynucleotides and expression vectors include the treatment of fibrosis in a subject.

公开(公告)号：US20190178761A1

公开(公告)日：2019-06-13

申请号：US16281176

申请日：2019-02-21

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Kathryn LINDSEY ,  Wanda SHOTSBERGER ,  Patricia M. HOUSER ,  Jack YANG

IPC: G01N1/36 ,  G01N1/28 ,  G01N1/30

Abstract: Embodiments disclosed herein relate to methods and apparatus for cell block preparation of cytology specimens. Specific embodiments relate to methods and apparatus for formalin fixed paraffin embedded cell block preparation of cytology specimens.

公开(公告)号：US20190117329A1

公开(公告)日：2019-04-25

申请号：US16220242

申请日：2018-12-14

Applicant: MUSC Foundation for Research Development

Inventor： Raymond Turner ,  Alex Spiotta ,  Aquilla Turk ,  Imran Chaudry ,  Mark Semler

IPC: A61B90/10 ,  A61B90/11

Abstract: A cranial anchor system configured to attach to an opening in a cranium includes an anchor member. The anchor member has a middle anchor portion and a lower anchor portion coupled to and disposed in a downward direction relative to the middle anchor portion. The lower anchor portion has a plurality of contact members, each of which have a leg that extends at least partially in the downward direction, a tab connected to the leg, and a rib disposed between the leg and the tab. The system further includes an outer sheath and an inner sheath disposed within the outer sheath and slidable relative to the outer sheath.

公开(公告)号：US10265136B2

公开(公告)日：2019-04-23

申请号：US15040523

申请日：2016-02-10

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Raymond Turner ,  Alex Spiotta ,  Aquilla Turk ,  Imran Chaudry ,  Mark Semler

IPC: A61B90/10 ,  A61B90/00 ,  A61B90/11 ,  A61B17/34

Abstract: A cranial anchor system configured to attach to an opening in a cranium includes an anchor member. The anchor member has a middle anchor portion and a lower anchor portion coupled to and disposed in a downward direction relative to the middle anchor portion. The lower anchor portion has a plurality of contact members, each of which have a leg that extends at least partially in the downward direction, a tab connected to the leg, and a rib disposed between the leg and the tab. The system further includes an outer sheath and an inner sheath disposed within the outer sheath and slidable relative to the outer sheath.

公开(公告)号：US20180120332A1

公开(公告)日：2018-05-03

申请号：US15726766

申请日：2017-10-06

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development

Inventor： Ying Mei ,  Jia Jia ,  Chung-Jen James Chou

IPC: G01N33/68 ,  C07K7/06 ,  C07K7/08 ,  A61P9/10

CPC classification number: G01N33/6893 ,  A61K38/00 ,  A61P9/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/52 ,  C07K14/70546 ,  C07K14/71 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C07K17/02 ,  G01N33/74 ,  G01N2333/70557 ,  G01N2333/70596 ,  G01N2500/04 ,  G01N2500/20 ,  G01N2800/7014

Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.

公开(公告)号：US20180077923A1

公开(公告)日：2018-03-22

申请号：US15825399

申请日：2017-11-29

Applicant: MUSC Foundation for Research Development

Inventor： Gautam GHATNEKAR ,  Robert GOURDIE ,  Jane JOURDAN

IPC: A01N1/02 ,  A61K38/17

CPC classification number: A01N1/0226 ,  A01N1/021 ,  A61K38/1709 ,  A61K38/177 ,  C07K14/705

Abstract: The present disclosure provides compositions and methods for treating or preventing macular degeneration in a subject. The disclosure also provides compositions and methods for preserving organs and tissues for transplantation, and for preventing cellular injury in organs or in subjects.

公开(公告)号：US09889018B2

公开(公告)日：2018-02-13

申请号：US15486739

申请日：2017-04-13

Applicant: MUSC Foundation for Research Development

Inventor： Mark Evald Semler ,  Bruce Frankel ,  Joseph Ruscito

IPC: A61F2/44 ,  A61F2/46

CPC classification number: A61F2/4425 ,  A61F2/44 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2002/30398 ,  A61F2002/30405 ,  A61F2002/30515 ,  A61F2002/30517 ,  A61F2002/30556 ,  A61F2002/30601 ,  A61F2002/30774 ,  A61F2002/30784 ,  A61F2002/30818 ,  A61F2002/30825 ,  A61F2002/30836 ,  A61F2002/4627 ,  A61F2230/0069 ,  A61F2250/0009

Abstract: Expandable vertebral body implants, systems, instruments, and methods of assembly and using the implants, systems, and instruments are disclosed. The vertebral body implant includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, wherein an end includes a plurality of first notches inset into the first rotating member, a second rotating member rotatably coupled to the second end, wherein an end includes a plurality of second notches inset into the second rotating member, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body implant and an insertion instrument. Methods for assembling and using the vertebral body implants and instruments are also disclosed.